Development of a scaffold displaying exoloops of RXFP1

Italian Journal of Anatomy and Embryology

Volumn 118, Issue 1 SUPPL., 2013, Pages 1-3

  Diepenhorst, Natalie A ^a   Gooley, Paul R ^a   Stone, Martin J ^b   Bathgate, Ross A D ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

GPCR; Protein engineering; Protein expression; Relaxin

Indexed keywords

G PROTEIN COUPLED RECEPTOR; RECEPTOR; RXFP1 PROTEIN, HUMAN;

ARTICLE; BINDING SITE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; METHODOLOGY; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS;

BINDING SITES; HUMANS; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PEPTIDE;

EID: 84893914966     PISSN: 11226714     EISSN: 20385129     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Bathgate, R. A., Ivell, R., et al., (2006) International Union of Pharmacology LVII: Recommendations for the Nomenclature of Receptors for Relaxin Family Peptides. Pharmacological reviews. 58(1): p. 7-31.
2. Bullesbach, E. E. and Schwabe, C., (2005) The Trap-like Relaxin-binding Site of the Leucine- rich G-protein-coupled Receptor 7. J. Biol. Chem. 280(14): p. 14051-14056.
3. Datta, A. and Stone, M. J., (2003) Soluble mimics of a chemokine receptor: Chemokine binding by receptor elements juxtaposed on a soluble scaffold. Protein Science. 12(11).
4. Halls, M. L., Bond, C. P., et al., (2005) Multiple Binding Sites Revealed by Interaction of Relaxin Family Peptides with Native and Chimeric Relaxin Family Peptide Receptors 1 and 2 (LGR7 and LGR8). J Pharmacol Exp Ther. 313(2): p. 677-687.
5. Hsu, S. Y., Nakabayashi, K., et al., (2002) Activation of orphan receptors by the hormone relaxin. Science. 295: p. 671-673.
6. Kong, R. C. K., Shilling, P. J., et al., (2010) Membrane receptors: Structure and function of the relaxin family peptide receptors. Molecular and Cellular Endocrinology. 320(1-2): p. 1-15.
7. Sudo, S., Kumagai, J., et al., (2003) H3 Relaxin Is a Specific Ligand for LGR7 and Activates the Receptor by Interacting with Both the Ectodomain and the Exoloop 2. J. Biol. Chem. 278(10): p. 7855-7862.