Ventilator-associated pneumonia: Overdiagnosis and treatment are common in medical and surgical intensive care units

Infection Control and Hospital Epidemiology

Volumn 35, Issue 3, 2014, Pages 278-284

  Nussenblatt, Veronique ^a   Avdic, Edina ^b   Berenholtz, Sean ^a   Daugherty, Elizabeth ^a   Hadhazy, Eric ^a   Lipsett, Pamela A ^a   Maragakis, Lisa L ^a   Perl, Trish M ^a   Speck, Kathleen ^a   Swoboda, Sandra M ^a   Ziai, Wendy ^a   Cosgrove, Sara E ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT;

DIAGNOSTIC ERROR; FEMALE; HUMAN; INAPPROPRIATE PRESCRIBING; INTENSIVE CARE; INTENSIVE CARE UNIT; MALE; MIDDLE AGED; PNEUMONIA, VENTILATOR-ASSOCIATED; RISK FACTOR; STATISTICS AND NUMERICAL DATA; TIME;

ANTI-BACTERIAL AGENTS; DIAGNOSTIC ERRORS; FEMALE; HUMANS; INAPPROPRIATE PRESCRIBING; INTENSIVE CARE; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; PNEUMONIA, VENTILATOR-ASSOCIATED; RISK FACTORS; TIME FACTORS;

EID: 84893911499     PISSN: 0899823X     EISSN: None     Source Type: Journal    
DOI: 10.1086/675279     Document Type: Article

References (30)

1. Chastre J, Fagon JY. Ventilator-associated pneumonia. Am J Res-pir Crit Care Med 2002;165:867-903.
2. Rello J, Ollendorf DA, Oster G, et al. Epidemiology and outcomes of ventilator-associated pneumonia in a large US database. Chest 2002;122:2115-2121.
3. Safdar N, Dezfulian C, Collard HR, et al. Clinical and economic consequences of ventilator-associated pneumonia: a systematic review. Crit Care Med 2005;33:2184-193.
4. Warren DK, Shukla SJ, Olsen MA, et al. Outcome and attributable cost of ventilator-associated pneumonia among intensive care unit patients in a suburban medical center. Crit Care Med 2003;31:1312-1317.
5. Heyland DK, Cook DJ, Griffith L, et al. The attributable morbidity and mortality of ventilator-associated pneumonia in the ' critically ill patient. The Canadian Critical Trials Group. Am J Respir Crit Care Med 1999;159:1249-1256.
6. Bercault N, Boulain T. Mortality rate attributable to ventilator-associated nosocomial pneumonia in an adult intensive care unit: a prospective case-control study. Crit Care Med 2001;29: 2303-2309.
7. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005;171:388-416.
8. Iregui M, Ward S, Sherman G, et al. Clinical importance of delays in the initiation of appropriate antibiotic treatment for, ventilator-associated pneumonia. Chest 2002;122:262-268.
9. Luna CM, Vujacich P, Niederman MS, et al. Impact of BAL data, on the therapy and outcome of ventilator-associated pneumonia. Chest 1997;111:676-685.
10. Fowler RA, Flavin KE, Barr J, et al. Variability in antibiotic, prescribing patterns and outcomes in patients with clinically suspected ventilator-associated pneumonia. Chest 2003;123:835-844.
11. Eachempati SR, Hydo LJ, Shou J, et al. Does de-escalation of antibiotic therapy for ventilator-associated pneumonia affect the likelihood of recurrent pneumonia or mortality in critically ill surgical patients? J Trauma 2009;66:1343-1348.
12. Leone M, Garcin F, Bouvenot J, et al. Ventilator-associated pneumonia: breaking the vicious circle of antibiotic overuse. Crit Care Med 2007;35:379-385.
13. Wilde AM, Nailor MD, Nicolau DP, et al. Inappropriate antibiotic use due to decreased compliance with a ventilator-associated pneumonia computerized clinical pathway: implications for continuing education and prospective feedback. Pharmacotherapy 2012;32:755-763.
14. Swoboda SM, Dixon T, Lipsett PA. Can the clinical pulmonary infection score impact ICU antibiotic days? Surg Infect 2006;7: 331-339.
15. Knaus WA, Draper EA, Wagner DP, et al. APACHE II: a severity of disease classification system. Crit Care Med 1985;13:818-829.
16. Fagon JY, Chastre J, Hance AJ, et al. Evaluation of clinical judgement in the identification and treatment of nosocomial pneumonia in ventilated patients. Chest 1993;103:547-553.
17. Chastre J, Wolff M, Fagon JY, et al. Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial. JAMA 2003;290:2588-2598.
18. Chastre J, Viau F, Brun P, et al. Prospective evaluation of the protected specimen brush for the diagnosis of pulmonary infections in ventilated patients. Am Rev Respir Dis 1984;130:924-929.
19. Fabregas N, Ewig S, Torres A, et al. Clinical diagnosis of ventilator associated pneumonia revisited: comparative validation using immediate post-mortem lung biopsies. Thorax 1999;54: 867-873.
20. Wunderink RG, Woldenberg LS, Zeiss J, et al. The radiologic diagnosis of autopsy-proven ventilator-associated pneumonia. Chest 1992;101:458-463.
21. Balthazar AB, Von Nowakonski A, De Capitani EM, et al. Diagnostic investigation of ventilator-associated pneumonia using bronchoalveolar lavage: comparative study with a postmortem lung biopsy. Braz J Med Biol Res 2001;34:993-1001.
22. Klompas M. Does this patient have ventilator-associated pneumonia? JAMA 2007;297:1583-1593.
23. Fartoukh M, Maitre B, Honore S, et al. Diagnosing pneumonia during mechanical ventilation: the clinical pulmonary infection score revisited. Am J Respir Crit Care Med 2003;168:173-179.
24. Singh N, Rogers P, Atwood CW, et al. Short-course empiric antibiotic therapy for patients with pulmonary infiltrates in the intensive care unit: a proposed solution for indiscriminate antibiotic prescription. Am J Respir Crit Care Med 2000;162:505-511.
25. Raman K, Nailor MD, Nicolau DP, et al. Early antibiotic discontinuation in patients with clinically suspected ventilator-associated pneumonia and negative quantitative bronchoscopy cultures. Crit Care Med 2013;41:1656-1663.
26. Ibrahim EH, Ward S, Sherman G, et al. Experience with a clinical guideline for the treatment of ventilator-associated pneumonia. Crit Care Med 2001;29:1109-1115.
27. Micek ST, Ward S, Fraser VJ, et al. A randomized controlled trial of an antibiotic discontinuation policy for clinically suspected ventilator-associated pneumonia. Chest 2004;125:1791-1799.
28. Fagon JY, Chastre J, Wolff M, et al. Invasive and noninvasive strategies for management of suspected ventilator-associated pneumonia: a randomized trial. Ann Intern Med 2000;132:621-630.
29. Shorr AF, Sherner JH, Jackson WL, et al. Invasive approaches to the diagnosis of ventilator-associated pneumonia: a meta-analysis. Crit Care Med 2005;33:46-53.
30. Centers for Disease Control and Prevention. CDC/NHSN Surveillance Definitions for Specific Types of Infections. Atlanta: Centers for Disease Control and Prevention, 2014. http://www.cdc.gov/nhsn/pdfs/pscmanual/17pscnosinfdef_current.pdf.