Comparison of total cortisol, free cortisol, and surrogate markers of free cortisol in diagnosis of adrenal insufficiency in patients with stable cirrhosis

Clinical Gastroenterology and Hepatology

Volumn 12, Issue 3, 2014, Pages

  Fede, Giuseppe ^a,b   Spadaro, Luisa ^b   Tomaselli, Tania ^b   Privitera, Graziella ^b   Scicali, Roberto ^b   Vasianopoulou, Panayota ^a   Thalassinos, Evangelos ^a   Martin, Nicholas ^a   Thomas, Michael ^a   Purrello, Francesco ^b   Burroughs, Andrew Kenneth ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF CATANIA   (Italy)

Author keywords

Adrenal function; Diagnosis; Diagnostic assay; Liver disease; Test

Indexed keywords

HYDROCORTISONE; TETRACOSACTIDE; TRANSCORTIN;

ADRENAL DISEASE; ADRENAL FUNCTION; ADRENAL INSUFFICIENCY; ADULT; ANALYTIC METHOD; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; COOLEN EQUATION; DEATH; DIAGNOSTIC PROCEDURE; DISEASE COURSE; DISEASE MARKER; FEMALE; FREE CORTISOL INDEX; HUMAN; HYDROCORTISONE BLOOD LEVEL; LIVER CIRRHOSIS; LIVER GRAFT; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OUTCOME ASSESSMENT; PROPORTIONAL HAZARDS MODEL; PROVOCATION TEST; SCORING SYSTEM;

ADRENAL FUNCTION; DIAGNOSIS; DIAGNOSTIC ASSAY; LIVER DISEASE; TEST;

ADRENAL INSUFFICIENCY; ADULT; BIOLOGICAL MARKERS; FEMALE; HUMANS; HYDROCORTISONE; LIVER CIRRHOSIS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SERUM;

EID: 84893903344     PISSN: 15423565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cgh.2013.08.028     Document Type: Article

References (34)

1. Fede G., Spadaro L., Tomaselli T., et al. Adrenocortical dysfunction in liver disease: a systematic review. Hepatology 2012, 55:1282-1291.
2. Marik P.E., Gayowski T., Starzl T.E. The hepatoadrenal syndrome: a common yet unrecognized clinical condition. Crit Care Med 2005, 33:1254-1259.
3. Tomaselli T., Privitera G., Fede G., et al. Corticosteroid replacement therapy in hepatoadrenal syndrome: case report with a review of the literature. Eur J Gastroenterol Hepatol 2012, 24:1344-1347.
4. Fernandez J., Escorsell A., Zabalza M., et al. Adrenal insufficiency in patients with cirrhosis and septic shock: effect of treatment with hydrocortisone on survival. Hepatology 2006, 44:1288-1295.
5. Harry R., Auzinger G., Wendon J., et al. The clinical importance of adrenal insufficiency in acute hepatic dysfunction. Hepatology 2002, 36:395-402.
6. Tsai M.H., Peng Y.S., Chen Y.C., et al. Adrenal insufficiency in patients with cirrhosis, severe sepsis and septic shock. Hepatology 2006, 43:673-681.
7. Arabi Y.M., Aljumah A., Dabbagh O., et al. Low-dose hydrocortisone in patients with cirrhosis and septic shock: a randomized controlled trial. CMAJ 2010, 182:1971-1977.
8. Fede G., Spadaro L., Tomaselli T., et al. Assessment of adrenocortical reserve in stable patients with cirrhosis. J Hepatol 2011, 54:243-250.
9. Galbois A., Rudler M., Massard J., et al. Assessment of adrenal function in cirrhotic patients: salivary cortisol should be preferred. J Hepatol 2010, 52:839-845.
10. McDonald J.A., Handelsman D.J., Dilworth P., et al. Hypothalamic-pituitary adrenal function in end-stage non-alcoholic liver disease. J Gastroenterol Hepatol 1993, 8:247-253.
11. Tan T., Chang L., Woodward A., et al. Characterising adrenal function using directly measured plasma free cortisol in stable severe liver disease. J Hepatol 2010, 53:841-848.
12. Zietz B., Lock G., Plach B., et al. Dysfunction of the hypothalamic-pituitary-glandular axes and relation to Child-Pugh classification in male patients with alcoholic and virus-related cirrhosis. Eur J Gastroenterol Hepatol 2003, 15:495-501.
13. Thevenot T., Dorin R., Monnet E., et al. High serum levels of free cortisol indicate severity of cirrhosis in hemodynamically stable patients. J Gastroenterol Hepatol 2012, 7:1596-1601.
14. Graupera J, Hernandez-Gea V, Rodriguez J, etal. Incidence and prognostic significance of relative adrenal insufficiency in cirrhotic patients with severe variceal bleeding. Hepatology 2011;52 (Suppl 1):121A-319A.
15. Triantos C., Marzigie M., Fede G., et al. Critical illness related corticosteroid insufficiency (CIRCI) in patients with cirrhosis andvariceal bleeding. Clin Gastroenterol Hepatol 2011, 9:595-601.
16. Risso A, Alessandria C, Elia C, etal. Adrenal dysfunction in nonseptic cirrhotic patients with ascites: impact on survival. Dig Liv Dis 2011;43:S74.
17. Marik P.E., Pastores S.M., Annane D., et al. Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine. Crit Care Med 2008, 36:1937-1949.
18. Kazlauskaite R., Evans A.T., Villabona C.V., et al. Corticotropin tests for hypothalamic-pituitary-adrenal insufficiency: a metaanalysis. J Clin Endocrinol Metab 2008, 93:4245-4253.
19. Coolens J.L., Van B.H., Heyns W. Clinical use of unbound plasma cortisol as calculated from total cortisol and corticosteroid-binding globulin. J Steroid Biochem 1987, 26:197-202.
20. Thevenot T., Borot S., Remy-Martin A., et al. Assessment of adrenal function in cirrhotic patients using concentration of serum-free and salivary cortisol. Liver Int 2011, 31:425-433.
21. Thevenot T., Borot S., Remy-Martin A., et al. Assessing adrenal function in cirrhotic patients: is there a reliable test?. Gastroenterol Clin Biol 2009, 33:584-588.
22. Gonc E.N., Kandemir N., Kinik ST. Significance of low-dose and standard-dose ACTH tests compared to overnight metyrapone test in the diagnosis of adrenal insufficiency in childhood. Horm Res 2003, 60:191-197.
23. Perogamvros I., Keevil B.G., Ray D.W., et al. Salivary cortisone is a potential biomarker for serum free cortisol. J Clin Endocrinol Metab 2010, 95:4951-4958.
24. Vincent R.P., Etogo-Asse F.E., Dew T., et al. Serum total cortisol and free cortisol index give different information regarding the hypothalamus-pituitary-adrenalaxis reserve in patients with liver impairment. Ann Clin Biochem 2009, 46(Pt 6):505-507.
25. Wiest R., Moleda L., Zietz B., et al. Uncoupling of sympathetic nervous system and hypothalamic-pituitary-adrenal axis in cirrhosis. J Gastroenterol Hepatol 2008, 23:1901-1908.
26. Vogeser M., Briegel J., Zachoval R., et al. Dialyzable free cortisol after stimulation with Synacthen. Clin Biochem 2002, 35:539-543.
27. Limor R., Tordjman K., Marcus Y., et al. Serum free cortisol as an ancillary tool in the interpretation of the low-dose 1-mug ACTH test. Clin Endocrinol (Oxf) 2011, 75:294-300.
28. Bland J.M., Altman D.G. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986, 1:307-310.
29. Oelkers W. Adrenal insufficiency. N Engl J Med 1996, 335:1206-1212.
30. Lewis J.G., Bagley C.J., Elder P.A., et al. Plasma free cortisol fraction reflects levels of functioning corticosteroid-binding globulin. Clin Chim Acta 2005, 359:189-194.
31. Marik P.E. Adrenal-exhaustion syndrome in patients with liver disease. Intensive Care Med 2006, 32:275-280.
32. Dorin R.I., Pai H.K., Ho J.T., et al. Validation of a simple method of estimating plasma free cortisol: role of cortisol binding to albumin. Clin Biochem 2009, 42:64-71.
33. Hamrahian A.H., Oseni T.S., Arafah B.M., et al. Measurements of serum free cortisol in critically ill patients. N Engl J Med 2004, 350:1629-1638.
34. Acevedo J., Fernandez J., Prado V., et al. Relative adrenal insufficiency in decompensated cirrhosis. relationship to short-term risk of severe sepsis, hepatorenal syndrome and death. Hepatology 2013, 58:1757-1765.