Mouse divalent metal transporter 1 is a copper transporter in HEK293 cells

BioMetals

Volumn 27, Issue 1, 2014, Pages 115-123

  Arredondo, Miguel ^a   Mendiburo, María José ^a   Flores, Sebastián ^a   Singleton, Steven T ^b   Garrick, Michael D ^b  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

Copper; DMT1; HEK293 cells; Tetracycline regulation; Transport

Indexed keywords

CATION TRANSPORT PROTEIN; COPPER; SOLUTE CARRIER FAMILY 11- (PROTON-COUPLED DIVALENT METAL ION TRANSPORTERS), MEMBER 2;

ANIMAL; HEK293 CELL LINE; HUMAN; METABOLISM; MOUSE; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; CATION TRANSPORT PROTEINS; COPPER; HEK293 CELLS; HUMANS; MICE;

EID: 84893869511     PISSN: 09660844     EISSN: 15728773     Source Type: Journal    
DOI: 10.1007/s10534-013-9691-6     Document Type: Article

References (23)

1. Arredondo M, Muñoz P, Mura C, Nuñez MT (2001) HFE inhibits apical iron uptake by intestinal epithelial (Caco-2) cells. FASEB J 15:1276-1278
2. 1+ transporter of intestinal cells. Am J Physiol Cell Physiol 284:C1525-C1530
3. Arredondo M, Cambiazo V, Tapia L, González-Agüero M, Núñez MT, Uauy R, Gonzalez M (2004) Copper overload affects copper and iron metabolism in Hep-G2 cells. Am J Physiol Gastrointest Liver Physiol 287:G27-32 (Pubitemid 38802115)
4. Cannone-Hergaux F, Gros P (2002) Expression of iron transporter DMT1 in kidney from normal and anemic mk mice. Kidney Int 62:147-156 (Pubitemid 34754057)
5. Ferguson CJ, Wareing M, Ward DT, Green R, Smith CP, Riccardi R (2001) Cellular localization of divalent metal transporter DMT-1 in rat kidney. Am J Physiol Renal Physiol 280:F803-F814
6. Fleming MD, Trenor CI, Su MA, Foernzler D, Beier DR, Dietrich WF, Andrews NC (1997) Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet 16:383-386 (Pubitemid 27323306)
7. Fleming MD, Romano MA, Su MA, Garrick LM, Garrick MD, Andrews NC (1998) Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc Natl Acad Sci USA 95:1148-1153 (Pubitemid 28124927)
8. Garrick MD, Núñez MT, Olivares M, Harris ED (2003a) Parallels and contrast between iron and copper metabolism. Biometals 16:1-8 (Pubitemid 36140212)
9. Garrick MD, Dolan KG, Horbinski C, Ghio AJ, Higgins D, Porubcin M, Moore EG, Hainsworth LN, Umbreit JN, Conrad ME, Feng L, Lis A, Roth JA, Singleton S, Garrick LM (2003b) DMT1: a mammalian transporter for multiple metals. Biometals 16:41-54 (Pubitemid 36140214)
10. Garrick MD, Kuo HC, Vargas F, Steven T, Singleton ST, Zhao L, Smith JJ, Paradkar PN, Roth JA, Garrick LM (2006) Comparison of mammalian cell lines expressing distinct isoforms of divalent metal transporter 1 in a tetracycline-regulated fashion. Biochem J 398(3):539-546 (Pubitemid 44453399)
11. Gunshin H, Mackenzie B, Berge UV, Gunshin Y, Romero MF, Boron WF et al (1997) Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature (London) 388:482-488 (Pubitemid 27328927)
12. Han O, Wessling-Resnick M (2002) Copper repletion enhances apical iron uptake and transepithelial iron transport by Caco-2 cells. Am J Physiol Gastrointest Liver Physiol 282:G527-G533
13. Harris ED (2001) Zinc and copper: evidence for interdependence, not antagonism. Nutr Rev 59:281-285
14. Lee J, Peña M, Nose Y, Thiele D (2002) Biochemical characterization of the human copper transporter Ctr1. J Biol Chem 277:4380-4387 (Pubitemid 34968704)
15. Linder MC (1991) The biochemistry of copper. Plenum, New York
16. Linder MC, Hazegh-Azam M (1996) Copper biochemistry and molecular biology. Am J Clin Nutr 63:795S-811S
17. Okada S (1996) Iron-induced tissue damage and cancer: the role of reactive oxygen species-free radicals. Pathol Int 46:311-332 (Pubitemid 26230953)
18. Olivi L, Sisk J, Bressler J (2001) Involvement of DMT1 in uptake of Cd in MDCK cells: role of protein kinase C. Am J Physiol Cell Physiol 281:C793-C800
19. Qian Y, Tiffany-Castiglioni E, Harris ED (1996) Functional analysis of a genetic defect of copper transport (Menkes disease) in different cell lines. Am J Physiol Cell Physiol 271:C378-C384
20. Tapia V, Arredondo M, Núñez MT (1996) Regulation of Fe absorption by cultured intestinal epithelia (Caco-2) cell monolayers with varied Fe status. Am J Physiol Gastrointest Liver Physiol 271:G443-G447
21. Tong KK, McArdle HJ (1995) Copper uptake by cultured trophoblast cells isolated from human term placenta. Biochim Biophys Acta 1269:233-236
22. Turlund JR (1995) Copper. In: Shils ME, Olson JA, Shike M (eds) Modern nutrition in health and disease, 8th edn. Lea & Febiger, Philadelphia, pp 231-241
23. Wareing M, Ferguson CJ, Green R, Riccardi D, Smith CP (2000) In vivo characterization of renal iron transport in the an-anesthetized rat. J Physiol (Lond) 524:581-586 (Pubitemid 30229520)