Synthesis, spectroscopic and DFT structural characterization of two novel ruthenium(III) oxicam complexes. in vivo evaluation of anti-inflammatory and gastric damaging activities

Journal of Inorganic Biochemistry

Volumn 134, Issue , 2014, Pages 25-35

  Tamasi, Gabriella ^a   Bernini, Caterina ^a   Corbini, Gianfranco ^a   Owens, Natalie F ^b   Messori, Luigi ^c   Scaletti, Federica ^c   Massai, Lara ^c   Giudice, Pietro Lo ^d   Cini, Renzo ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b EMORY UNIVERSITY   (United States)

^c UNIVERSITY OF FLORENCE   (Italy)

^d Sigma Tau SpA   (Italy)

Author keywords

Anti cancer drugs; Anti inflammatory drugs; Density functional; Ruthenium complexes; Spectroscopy

Indexed keywords

COORDINATION COMPOUND; CYTOCHROME C; LIGAND; LYSOZYME; NONSTEROID ANTIINFLAMMATORY AGENT; PIROXICAM; PROTEIN BINDING; RUTHENIUM CHLORIDE; RUTHENIUM DERIVATIVE; SERUM ALBUMIN; TENOXICAM;

ANALOGS AND DERIVATIVES; ANIMAL; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; DRUG STABILITY; EDEMA; HINDLIMB; HUMAN; MALE; QUANTUM THEORY; RAT; SOLUBILITY; SYNTHESIS; TUMOR CELL LINE; WISTAR RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE, TUMOR; CELL SURVIVAL; COORDINATION COMPLEXES; CYTOCHROMES C; DRUG STABILITY; EDEMA; HINDLIMB; HUMANS; LIGANDS; MALE; MURAMIDASE; PIROXICAM; PROTEIN BINDING; QUANTUM THEORY; RATS; RATS, WISTAR; RUTHENIUM COMPOUNDS; SERUM ALBUMIN; SOLUBILITY;

EID: 84893868369     PISSN: 01620134     EISSN: 18733344     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2014.01.011     Document Type: Article

References (32)

1. P.J. Dyson, and G. Sava Dalton Trans. 2006 1929 1933
2. M.A. Jakupec, E. Reisner, A. Eichinger, M. Pongratz, V.B. Arion, M. Galanski, C.G. Hartinger, and B.K. Keppler J. Med. Chem. 48 2005 2831 2837
3. D.L. McCormick, J.M. Phillips, T.L. Horn, W.D. Johnson, V.E. Steele, and R.A. Lubet Cancer. Prev. Res. 3 2010 73 81
4. B. Xin, Y. Yokoyama, T. Shigeto, and H. Mizunuma Pathol. Oncol. Res. 13 2007 365 369
5. A. Verdina, I. Cardillo, A. Nebbioso, R. Galati, S. Menegozzo, L. Altucci, A. Sacchi, and A. Baldi J. Transl. Med. 6 2008 27 35
6. R. Cini, G. Tamasi, S. Defazio, and M.B. Hursthouse J. Inorg. Biochem. 101 2007 1140 1152
7. W.P. Caron, K.P. Morgan, B.A. Zamboni, and W. Zamboni Clin. Cancer Res. 19 2013 3309 3315
8. M. Casolaro, R. Cini, E. Maellaro, B. Del Bello, and M. Ferrali Biomacromolecules 10 2009 944 949
9. G. Tamasi, M. Casolaro, A. Magnani, A. Sega, L. Chiasserini, L. Messori, C. Gabbiani, S. Mojtaba Valiahdi, M. Jakupec, B.K. Keppler, M.B. Hursthouse, and R. Cini J. Inorg. Biochem. 104 2010 799 814
10. HyperChem™, Molecular Modeling System, Release 7.5 Pro For Windows 1997 Hypercube Inc. Gainsville, FL
11. HyperChem™ Reference Manual 1997 Hypercube Inc. Gainsville, FL
12. M.J. Frisch, G.W. Trucks, H.B. Schlegel, G.E. Scuseria, M.A. Robb, J.R. Cheeseman, J.A. Montgomery Jr., T. Vreven, K.N. Kudin, J.C. Burant, J.M. Millam, S.S. Iyengar, J. Tomasi, V. Barone, B. Mennucci, M. Cossi, G. Scalmani, N. Rega, G.A. Petersson, H. Nakatsuji, M. Hada, M. Ehara, K. Toyota, R. Fukuda, J. Hasegawa, M. Ishida, T. Nakajima, Y. Honda, O. Kitao, H. Nakai, M. Klene, X. Li, J.E. Knox, H.P. Hratchian, J.B. Cross, C. Adamo, J. Jaramillo, R. Gomperts, R.E. Stratmann, O. Yazyev, A.J. Austin, R. Cammi, C. Pomelli, J.W. Ochterski, P.Y. Ayala, K. Morokuma, G.A. Voth, P. Salvador, J.J. Dannenberg, V.G. Zakrzewski, S. Dapprich, A.D. Daniels, M.C. Strain, O. Farkas, D.K. Malick, A.D. Rabuck, K. Raghavachari, J.B. Foresman, J.V. Ortiz, Q. Cui, A.G. Baboul, S. Clifford, J. Cioslowski, B.B. Stefanov, G. Liu, A. Liashenko, P. Piskorz, I. Komaromi, R.L. Martin, D.J. Fox, T. Keith, M.A. Al-Laham, C.Y. Peng, A. Nanayakkara, M. Challacombe, P.M.W. Gill, B. Johnson, W. Chen, M.W. Wong, C. Gonzalez, and J.A. Pople 2013 Gaussian, Inc. Pittsburgh PA (Gaussian03, Revision B.05, 2003 and Gaussian09, Revision D.01)
13. J.B. Foresman, and A. Frisch Exploring Chemistry with Electronic Structure Methods Second edition 1996 Gaussian Inc. Pittsburg PA
14. GaussView3.0, Gaussian, Inc., Carneige Office Park-Bldg 6, Pittsburg PA, 15106 USA
15. C. Pisano, D. Grandi, G. Morini, G. Coppelli, L. Vesci, P. Lo Giudice, S. Pace, L. Pacifici, A. Longo, G. Coruzzi, and P. Carminati Dig. Dis. Sci. 44 1999 713 724
16. P. Skehan, R. Storeng, D. Scudiero, A. Monks, J. McMahon, D. Vistica, T.W. Warren, H. Bokesch, S. Kenney, and M.R. Boyd J. Natl. Cancer Inst. 82 1990 1107 1112
17. M. Casolaro, E. Paccagnini, R. Mendichi, and Y. Ito Macromolecules 38 2005 2460 2468
18. M. Casolaro, Y. Ito, T. Ishii, S. Bottari, F. Samperi, and R. Mendichi Express Polym. Lett. 2 2008 165 183
19. G. Tamasi Open Cryst. J. 3 2010 41 53
20. G. Tamasi, and R. Cini Biomimetic Metal Phenolates in The Chemistry of Metal Phenolates J. Zabicky, April 2014 Wiley Chichester (requested review work, in press)
21. B. Kojic Acta Crystallogr. B38 1982 2948 2952
22. T. Hasegawa, T.C. Lau, H. Taube, and W.P. Schaefer Inorg. Chem. 30 1991 2921 2928
23. S. Bhattacharya, A. Chakravorty, F.A. Cotton, R. Mukherjee, and W. Schwotzer Inorg. Chem. 23 1984 1709 1713
24. M.R. Moya-Hernandez, A. Mederos, S. Dominguez, A. Orlandini, C.A. Ghilardi, F. Cecconi, E. Gonzalez-Vergara, and A. Rojas-Hernandez J. Inorg. Biochem. 95 2003 131 140
25. A. Casini, C. Gabbiani, G. Mastrobuoni, L. Messori, G. Moneti, and G. Pieraccini Chem. Med. Chem. 1 2006 413 417
26. C. Gabbiani, L. Massai, F. Scaletti, E. Michelucci, L. Maiore, M.A. Cinellu, and L. Messori J. Biol. Inorg. Chem. 17 2012 1293 1302
27. C.-C. Lin, and A.T. Metters Adv. Drug Deliv. Rev. 58 2006 1379 1408 (and references cited therein)
28. G. Tamasi, F. Serinelli, M. Consumi, A. Magnani, M. Casolaro, and R. Cini J. Inorg. Biochem. 102 2008 1862 1873
29. E. Dubler A. Sigel, H. Sigel, Metal Ions in Biological Systems 1996 Marcel Dekker New York (Chapter 8)
30. M.F. Primik, G. Mühlgassner, M.A. Jakupec, O. Zava, P.J. Dyson, V.B. Arion, and B.K. Keppler Inorg. Chem. 49 2010 302 311 (and references cited therein)
31. C. Scarpignato Curr. Med. Chem. 20 2013 2415 2437
32. H.S. Chiong, Y.K. Yong, Z. Ahmad, M.R. Sulaiman, Z.A. Zakaria, K.H. Yuen, and M.N. Hakim Int. J. Nanomedicine 8 2013 1245 1255