Astrocytic p-connexin 43 regulates neuronal autophagy in the hippocampus following traumatic brain injury in rats

Molecular Medicine Reports

Volumn 9, Issue 1, 2014, Pages 77-82

  Sun, Li Qian ^a   Gao, Jun Ling ^b   Cui, Chang Men ^a   Cui, Ying ^c   Jing, Xiao Bin ^d   Zhao, Man Man ^b   Wang, Yong Chao ^b   Tian, Yan Xia ^b   Wang, Kai Jie ^c   Cui, Jian Zhong ^a,c  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b HEBEI UNITED UNIVERSITY   (China)

^c Tangshan Gongren Hospital   (China)

^d Tangshan Eye Hospital   (China)

Author keywords

Autophagy; CBX; CX43; LC3; TBI

Indexed keywords

ANIMALS; ASTROCYTES; AUTOPHAGY; BRAIN INJURIES; CARBENOXOLONE; CONNEXIN 43; HIPPOCAMPUS; HISTAMINE H2 ANTAGONISTS; MALE; MICROTUBULE-ASSOCIATED PROTEINS; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84893836628     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2013.1787     Document Type: Article

References (40)

1. Mammis A, McIntosh TK and Maniker AH: Erythropoietin as a neuroprotective agent in traumatic brain injury Review. Surgical Neurol 71: 527-531, 2009
2. Luo CL, Chen XP, Yang R, et al: Cathepsin B contributes to traumatic brain injury-induced cell death through a mitochondria-mediated apoptotic pathway. J Neurosci Res 88: 2847-2858, 2010
3. Tehranian R, Rose ME, Vagni V, et al: Disruption of Bax protein prevents neuronal cell death but produces cognitive impairment in mice following traumatic brain injury. J Neurotrauma 25: 755-767, 2008
4. Lai Y, Hickey RW, Chen Y, et al: Autophagy is increased after traumatic brain injury in mice and is partially inhibited by the antioxidant gamma-glutamylcysteinyl ethyl ester. J Cereb Blood Flow Metab 28: 540-550, 2008
5. Pozuelo-Rubio M: Regulation of autophagic activity by 14-3-3ζ proteins associated with class III phosphatidylinositol-3-kinase. Cell Death Differ 18: 479-492, 2011
6. Liu CL, Chen S, Dietrich D and Hu BR: Changes in autophagy after traumatic brain injury. J Cereb Blood Flow Metab 28: 674-683, 2008
7. Cotrina ML and Nedergaard M: Physiological and pathological functions of P2X7 receptor in the spinal cord. Purinergic Signal 5: 223-232, 2009
8. Bennett MV, Contreras JE, Bukauskas FF and Sáez JC: New roles for astrocytes: gap junction hemichannels have something to communicate. Trends Neurosci 26: 610-617, 2003
9. Cottrell GT, Lin R, Warn-Cramer BJ, Lau AF and Burt JM: Mechanism of v-Src-and mitogen-activated protein kinase-induced reduction of gap junction communication. Am J Physiol Cell Physiol 284: C511-C520, 2003.
10. Zhao X, Ahram A, Berman RF, Muizelaar JP and Lyeth BG: Early loss of astrocytes after experimental traumatic brain injury. Glia 44: 140-152, 2003.
11. Giaume C, Tabernero A and Medina JM: Metabolic trafficking through astrocytic gap junctions. Glia 21: 114-123, 1997.
12. Lin JH, Weigel H, Cotrina ML, et al: Gap-junction-mediated propagation and amplification of cell injury. Nature Neurosci 1: 494-500, 1998.
13. Marmarou A, Foda MA, van den Brink W, Campbell J, Kita H and Demetriadou K: A new model of diffuse brain injury in rats. J Neurosurg 80: 291-300, 1994.
14. Khorasani MZ, Hosseinzadeh SA and Vakili A: Effect of central microinjection of carbenoxolone in an experimental model of focal cerebral ischemia. Pak J Pharm Sci 22: 349-354, 2009.
15. Milad MR, Vidal-Gonzalez I and Quirk GJ: Electrical stimulation of medial prefrontal cortex reduces conditioned fear in a temporally specific manner. Behav Neurosci 118: 389-394, 2004.
16. Song SX, Gao JL, Wang KJ, et al: Attenuation of brain edema and spatial learning deficits by the inhibition of NADPH oxidase activity using apocynin following diffuse traumatic brain injury in rats. Mol Med Rep: 327-331, 2012.
17. Eghwrudjakpor PO and Allison AB: Oxidative stress following traumatic brain injury: enhancement of endogenous antioxidant defense systems and the promise of improved outcome. Niger J Med 19: 14-21, 2010.
18. Uryu K, Laurer H, McIntosh T, et al: Repetitive mild brain trauma accelerates Abeta deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer amyloidosis. J Neurosci 22: 446-454, 2002.
19. Werner C and Engelhard K: Pathophysiology of traumatic brain injury. Br J Anaesth 99: 4-9, 2007.
20. Geng J and Klionsky DJ: The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. ′Protein modifications: beyond the usual suspects′ review series. EMBO Rep 9: 859-864, 2008.
21. Mizushima N, Levine B, Cuervo AM and Klionsky DJ: Autophagy fights disease through cellular self-digestion. Nature 451: 1069-1075, 2008.
22. Meijer AJ and Codogno P: Autophagy: regulation and role in disease. Crit Rev Clin Lab Sci 46: 210-240, 2009.
23. Luo CL, Li BX, Li QQ, et al: Autophagy is involved in traumatic brain injury-induced cell death and contributes to functional outcome deficits in mice. Neuroscience 184: 54-63, 2011.
24. Clark RS, Bayir H, Chu CT, Alber SM, Kochanek PM and Watkins SC: Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness. Autophagy 4: 88-90, 2008.
25. Maiuri MC, Criollo A, Tasdemir E, et al: BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy 3: 374-376, 2007.
26. Kabeya Y, Mizushima N, Yamamoto A, Oshitani-Okamoto S, Ohsumi Y and Yoshimori T: LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci 117: 2805-2812, 2004.
27. Araque A, Parpura V, Sanzgiri RP and Haydon PG: Tripartite synapses: glia, the unacknowledged partner. Trends Neurosci 22: 208-215, 1999.
28. Tsacopoulos M and Magistretti PJ: Metabolic coupling between glia and neurons. J Neurosci 16: 877-885, 1996.
29. Dermietzel R and Spray DC: From neuro-glue (′Nervenkitt′) to glia: a prologue. Glia 24: 1-7, 1998.
30. Giaume C, Fromaget C, el Aoumari A, Cordier J, Glowinski J and Gros D: Gap junctions in cultured astrocytes: single-channel currents and characterization of channel-forming protein. Neuron 6: 133-143, 1991.
31. Paul DL: New functions for gap junctions. Curr Opin Cell Biol 7: 665-672, 1995.
32. Hansson E, Muyderman H, Leonova J, et al: Astroglia and glutamate in physiology and pathology: aspects on glutamate transport, glutamate-induced cell swelling and gap-junction communication. Neurochem Int 37: 317-329, 2000.
33. Nakase T, Fushiki S and Naus CC: Astrocytic gap junctions composed of connexin 43 reduce apoptotic neuronal damage in cerebral ischemia. Stroke 34: 1987-1993, 2003.
34. Rozental R, Srinivas M and Spray DC: How to close a gap junction channel. Efficacies and potencies of uncoupling agents. Methods Mol Biol 154: 447-476, 2001.
35. Magistretti PJ: Cellular bases of functional brain imaging: insights from neuron-glia metabolic coupling. Brain Res 886: 108-112, 2000.
36. Anderson CM and Swanson RA: Astrocyte glutamate transport: review of properties, regulation, and physiological functions. Glia 32: 1-14, 2000.
37. Hardingham GE and Bading H: The Yin and Yang of NMDA receptor signalling. Trends Neurosci 26: 81-89, 2003.
38. Rami A, Volkmann T and Winckler J: Effective reduction of neuronal death by inhibiting gap junctional intercellular communication in a rodent model of global transient cerebral ischemia. Exp Neurol 170: 297-304, 2001.
39. Zhang YB, Li SX, Chen XP, et al: Autophagy is activated and might protect neurons from degeneration after traumatic brain injury. Neurosci Bull 24: 143-149, 2008.
40. Chew SS, Johnson CS, Green CR and Danesh-Meyer HV: Role of connexin43 in central nervous system injury. Exp Neurol 225: 250-261, 2010.