Augmenting glial cell-line derived neurotrophic factor signaling to treat painful neuropathies

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 6, 2014, Pages 2060-2061

  Höke, Ahmet ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; ERYTHROMELALGIA; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR RECEPTORS; PROTO-ONCOGENE PROTEINS C-RET; QUINOLINES; SIGNAL TRANSDUCTION;

EID: 84893827410     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1324047111     Document Type: Note

References (16)

1. Trivedi JR, Silvestri NJ, Wolfe GI (2013) Treatment of painful peripheral neuropathy. Neurol Clin 31(2):377-403.
2. Hedstrom KL, Murtie JC, Albers K, Calcutt NA, Corfas G (2014) Treating small fiber neuropathy by topical application of a small molecule modulator of ligand-induced GFRα/RET receptor signaling. Proc Natl Acad Sci USA 111:2325-2330.
3. Lumpkin EA, Caterina MJ (2007) Mechanisms of sensory transduction in the skin. Nature 445(7130):858-865.
4. Apfel SC (2000) Neurotrophic factors and pain. Clin J Pain 16(2, Suppl):S7-S11.
5. Watson JJ, Allen SJ, Dawbarn D (2008) Targeting nerve growth factor in pain: What is the therapeutic potential? BioDrugs 22(6): 349-359.
6. Boucher TJ, McMahon SB (2001) Neurotrophic factors and neuropathic pain. Curr Opin Pharmacol 1(1):66-72.
7. Sah DW, Ossipov MH, Rossomando A, Silvian L, Porreca F (2005) New approaches for the treatment of pain: The GDNF family of neurotrophic growth factors. Curr Top Med Chem 5(6): 577-583.
8. Akkina SK, Patterson CL, Wright DE (2001) GDNF rescues nonpeptidergic unmyelinated primary afferents in streptozotocin-treated diabetic mice. Exp Neurol 167(1): 173-182.
9. Liu GS, et al. (2009) Peripheral gene transfer of glial cell-derived neurotrophic factor ameliorates neuropathic deficits in diabetic rats. Hum Gene Ther 20(7):715-727.
10. Tokugawa K, et al. (2003) XIB4035, a novel nonpeptidyl small molecule agonist for GFRalpha-1. Neurochem Int 42(1): 81-86.
11. Runeberg-Roos P, Saarma M (2007) Neurotrophic factor receptor RET: Structure, cell biology, and inherited diseases. Ann Med 39(8): 572-580.
12. McArthur JC (2012) Painful small fiber neuropathies. Continuum (Minneap Minn) 18(1):106-125.
13. Boucher TJ, et al. (2000) Potent analgesic effects of GDNF in neuropathic pain states. Science 290(5489):124-127.
14. Wang R, et al. (2003) Glial cell line-derived neurotrophic factor normalizes neurochemical changes in injured dorsal root ganglion neurons and prevents the expression of experimental neuropathic pain. Neuroscience 121(3):815-824.
15. Takasu K, Sakai A, Hanawa H, Shimada T, Suzuki H (2011) Overexpression of GDNF in the uninjured DRG exerts analgesic effects on neuropathic pain following segmental spinal nerve ligation in mice. J Pain 12(11):1130-1139.
16. Wolfe D, Mata M, Fink DJ (2012) Targeted drug delivery to the peripheral nervous system using gene therapy. Neurosci Lett 527(2):85-89.