Mevalonate production by engineered acetogen biocatalyst during continuous fermentation of syngas or CO2/H2 blend

Bioprocess and Biosystems Engineering

Volumn 37, Issue 2, 2014, Pages 245-260

  Kiriukhin, Michael ^a,b   Tyurin, Michael ^a,b  

^a Syngas Biofuels Energy Inc   (United States)

^b Ajinomoto Genetika Research Institute   (Russian Federation)

Author keywords

aatTn7; Acetogens; ack; Mevalonate; pta; spo0; Syngas fermentation

Indexed keywords

ACETOGENINS; BASE SEQUENCE; BIOCATALYSIS; CARBON DIOXIDE; CHROMOSOMES, BACTERIAL; CLOSTRIDIUM; DNA PRIMERS; FERMENTATION; HYDROGEN; MEVALONIC ACID; POLYMERASE CHAIN REACTION;

EID: 84893824210     PISSN: 16157591     EISSN: 16157605     Source Type: Journal    
DOI: 10.1007/s00449-013-0991-6     Document Type: Article

References (38)

1. Fischer CR, Klein-Marcuschamer D, Stephanopoulos G (2008) Selection and optimization of microbial hosts for biofuels production. Metab Eng 10(6):295-304
2. Demain AL (2009) Biosolutions to the energy problem. J Ind Microbiol Biotechnol 36(3):319-332
3. Köpke M, Michalcea C, Liew F-M, Tizard JH, Ali MS, Conolly JJ, Al-Sinawi B, Simpson SD (2011) 2, 3-butanediol production by acetogenic bacteria, an alternative route to chemical synthesis, using industrial waste gas. Appl Environ Microbiol 77(15):5467-5475
4. Gaddy JL, Arora DD, Ko C-W, Phillips JR, Basu R, Wikstrom CV, Clausen EC (2001) Methods for increasing the production of ethanol from microbial fermentation. US Patent 7285402
5. Abubackar HN, Veiga MC, Kennes C (2012) Biological conversion of carbon monoxide to ethanol: effect of pH, gas pressure, reducing agent and yeast extract. Bioresource Technol 114:518-522
6. Berzin V, Kiriukhin M, Tyurin M (2012) Selective production of acetone during continuous synthesis gas fermentation by engineered biocatalyst Clostridium sp. MAceT113. Lett Appl Microbiol 55:149-154. doi: 10.1111/j.1472-765X.2012.03272.x
7. Berzin V, Kiriukhin M, Tyurin M (2012) Cre-lox66/lox71-based elimination of phosphotransacetylase or acetaldehyde dehydrogenase shifted carbon flux in acetogen rendering selective overproduction of ethanol or acetate. Appl Biochem Biotechnol. doi: 10.1007/s12010-012-9864-8
8. Müller V (2003) Energy conservation in acetogenic bacteria. Appl Environ Microbiol 69(11):6345-6353. doi: 10.1128/AEM.69.11.6345-6353.2003 (Pubitemid 37420162)
9. Yang J, Xian M, Su S, Zhao G, Nie Q, Jiang X, Zheng Y, Liu W (2012) Enhancing production of bio-isoprene using hybrid MVA pathway and isoprene synthase in E. coli. Plos One 7(4):e33509. doi: 10.1371/journal.pone.0033509
10. Van Leeuwen BNM, van der Wulp AM, Duijnstee I, van Maris AJA, Straathof AJJ (2012) Fermentative production of isobutene. Appl Microbiol Biotechnol 93(4):1377-1387. doi: 10.1007/s00253-011-3853-7
11. Paniagua-Michel J, Olmos-Soto J, Ruiz MA (2012) Pathways of carotenoid biosynthesis in bacteria and microalgae. Methods Mol Biol 892:1-12
12. Siddiqi MA, Rodwell VW (1967) Bacterial metabolism of mevalonic acid. J Bacteriol 93(1):207-214
13. Van Laar TA, Lin Y-H, Miller CL, Karna SLR, Chambers JP, Seshu J (2012) Effect of levels of acetate on the mevalonate pathway of Borrelia burgdorferi. Plos One 7(5):e38171. doi: 10.1371/journal.pone.0038171
14. Robinson JM (2004) Lactones as new oxygenate fuel additives, fuels based thereon and methods for using same. US 20060096158Al
15. Berzin V, Kiriukhin M, Tyurin M (2013) Selective n-butanol production by Clostridium sp. MTButOH1365 during continuous synthesis gas fermentation due to expression of synthetic thiolase, 3-hydroxy butyryl-CoA dehydrogenase, crotonase, butyryl-CoA dehydrogenase, butyraldehyde dehydrogenase and NAD-dependent butanol dehydrogenase. Appl Biochem Biotechnol. doi: 10.1007/s12010-012-0060-7
16. Tyurin M, Kiriukhin M, Berzin V (2012) Electrofusion of cells of acetogen Clostridium sp. MT351 with erm(B) or cat in the chromosome. J Biotech Res 4:1-12
17. 2 blend fermentation. J Appl Microbiol. doi: 10.1111/jam.12123
18. Craig NL (1991) Micro Review. Tn7: a target site-specific transposon. Molecular Microbiol 5(11):2569-2573 (Pubitemid 21895988)
19. DeLisa MP, Conrado RJ (2009) Synthetic metabolic pipelines. Nat Biotechnol 27:728-729. doi: 10.1038/nbt0809-728
20. Berzin V, Tyurin M (2012) Acetogen biocatalyst Clostridium sp. MTEtOH871 engineered with our proprietary electrotransformation technology and equipment: continuous synthesis gas fermentation for selective ethanol production. J Biotech Res 4:54-64
21. Tanner RS, Miller LM, Yang D (1993) Clostridium ljungdahlii sp. nov., an acetogenic species in clostridial rRNA homology group I. Int J Syst Bacteriol 43(2):232-236 (Pubitemid 23118460)
22. Tyurin, MV (1992) The method and apparatus for electric cell treatment using partial power capacitor discharge via the sample and the power tetrode. Russian Patent 2005776
23. Tyurin M, Desai S, Lynd L (2004) Electrotransformation of Clostridium thermocellum. Appl Environ Microbiol 70(2):883-890 (Pubitemid 38568212)
24. Tyurin MV, Sullivan CR, Lynd LR (2005) Induced oscillations play an important role in high efficiency transformation of thermophilic anaerobes. Appl Environ Microbiol 71:8069-8076 (Pubitemid 41805091)
25. Leibig M, Krismer B, Kolb M, Friede A, Götz F, Bertram R (2008) Marker removal in staphylococci via Cre recombinase and different lox sites. Appl Environ Microbiol 74(5):1316-1323 (Pubitemid 351358425)
26. Tyurin M, Lynd LR, Wiegel J (2006) Genetic delivery systems for strictly anaerobic thermophiles. In: Rainey FA, Oren A (eds) Methods in microbiology, vol 35, 1st edn. Academic Press, Elsevier, Amsterdam, pp 307-328
27. Ross SM (2000) Introduction to probability and statistics for engineers and scientists, 2nd edn. Academic Press, San Diego
28. Drake HL (1994) Acetogenesis. Chapman & Hall, NY
29. Berzin V, Kiriukhin M, Tyurin M (2013) "Curing" of plasmid DNA in acetogen using microwave or applying an electric pulse improves cell growth and metabolite production as compared to the plasmid-harboring strain. Arch Microbiol 195(3):181-188. doi: 10.1007/s00203-012-0862-6
30. Chiou CT (2003) Partition and adsorption of organic contaminants in environmental systems. John Wiley & Sons, NJ, p 274
31. Simon SA, Gutknecht J (1980) Solubility of carbon dioxide in lipid bilayer membranes and organic solvents. Biochim Biophys Acta 596(3):352-358
32. Bramucci MG, Flint D, Miller ES, Nagarajan V, Sedkova N, Singh M, Van Dyk TK (2008) Method of production of isobutanol. US 20080274526 A1
33. Donaldson GK, Eliot AC, Flint D, Maggio-Hall LA, Nagarajan V (2006) Fermentive production of four carbon alcohols. US7851188
34. Wang C, Yoon SH, Shah AA, Chung YR, Kim JY, Choi ES, Keasling JD, Kim SW (2010) Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway. Biotechnol Bioeng 107(3):421-429. doi: 10.1002/bit.22831
35. Tyurin MV, Lynd LR, Wiegel J (2006) Gene transfer systems for obligately anaerobic thermophilic bacteria Extremophilic microorganisms. In: Rainey Fred, Oren Aharon (eds) Methods in microbiology, vol 35. Elsevier, Amsterdam, pp 307-328
36. Lin L, Song H, Ji Y, He Z, Pu Y et al (2010) Ultrasound-mediated DNA transformation in thermophilic gram-positive anaerobes. Plos One 5(9):e12582. doi: 10.1371/journal.pone.0012582
37. Tyurin MV, Doroshenko VG, Oparina N, Yu (1997) Electrofusion of Escherichia coli cells. Membr Cell Biol 11(1):121-129 (Pubitemid 27323059)
38. Kita A, Iwasaki Y, Sakai S, Okuto S, Takaoka K, Suzuki T, Yano S, Sawayama S, Tajima T, Kato J, Nishio N, Murakami K, Nakashimada Y (2013) Development of genetic transformation and heterologous expression system in carboxydotrophic thermophilic acetogen Moorella thermoacetica. J Biosci Bioeng 115(4):347-352