Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract

Journal of Ethnopharmacology

Volumn 152, Issue 1, 2014, Pages 190-200

  Kon, Risako ^a   Ikarashi, Nobutomo ^a   Nagoya, Chika ^a   Takayama, Tomoko ^a   Kusunoki, Yoshiki ^a   Ishii, Makoto ^a   Ueda, Harumi ^a   Ochiai, Wataru ^a   Machida, Yoshiaki ^a   Sugita, Kazuyuki ^a   Sugiyama, Kiyoshi ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

Aquaporin 3; Laxative; Macrophage; Rheinanthrone; Sennoside A

Indexed keywords

AQUAPORIN 3; INDOMETACIN; LAXATIVE; PROSTAGLANDIN E2; RHEIN; RHEIN ANTHRONE; RHUBARB EXTRACT; SENNOSIDE A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; COLON; COLON CANCER; CONTROLLED STUDY; DIARRHEA; DRUG EFFECT; FECAL WATER CONTENT; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INFANT; MACROPHAGE ACTIVATION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WATER CONTENT; WESTERN BLOTTING;

RATTUS; RHEUM X HYBRIDUM;

AQUAPORIN-3; LAXATIVE; MACROPHAGE; PGE(2); RHEINANTHRONE; SENNOSIDE A;

ANIMALS; ANTHRACENES; AQUAPORIN 3; CELL LINE; COLON; COLONIC NEOPLASMS; DIARRHEA; DINOPROSTONE; HT29 CELLS; HUMANS; INDOMETHACIN; INTESTINAL MUCOSA; LAXATIVES; MACROPHAGE ACTIVATION; MALE; RATS; RATS, WISTAR; RHEUM; SENNA EXTRACT;

EID: 84893824124     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.12.055     Document Type: Article

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