The VACS index predicts mortality in a young, healthy HIV population starting highly active antiretroviral therapy

Journal of Acquired Immune Deficiency Syndromes

Volumn 65, Issue 2, 2014, Pages 226-230

  Bebu, Ionut ^a   Tate, Janet ^b   Rimland, David ^c   Mesner, Octavio ^a   Macalino, Grace E ^a   Ganesan, Anuradha ^a,d   Okulicz, Jason F ^a,e   Bavaro, Mary ^a,f   Weintrob, Amy C ^a,d   Justice, Amy C ^b   Agan, Brian K ^a  

^a Uniformed Services University of the Health Sciences   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d WALTER REED ARMY MEDICAL CENTER   (United States)

^e SAN ANTONIO MILITARY MEDICAL CENTER   (United States)

^f NAVAL MEDICAL CENTER SAN DIEGO   (United States)

Author keywords

Early diagnosis; HIV; Military; VACS index; Validation

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ACCOUNTING; ADULT; AGING; ARTICLE; CALIBRATION; CAUSE OF DEATH; COHORT ANALYSIS; CONTROLLED STUDY; EARLY DIAGNOSIS; EXTERNAL VALIDITY; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HISTORY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LABORATORY TEST; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MORTALITY; PREDICTION; PRIORITY JOURNAL; RISK ASSESSMENT; SCORING SYSTEM; STANDARD; VETERAN; VETERANS AGING COHORT STUDY; VIRUS LOAD; YOUNG ADULT;

ADULT; AGING; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; COHORT STUDIES; DECISION SUPPORT TECHNIQUES; FEMALE; HIV INFECTIONS; HUMANS; MALE; PROSPECTIVE STUDIES; RISK ASSESSMENT; SURVIVAL ANALYSIS; UNITED STATES;

EID: 84893817114     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0000000000000045     Document Type: Article

References (13)

1. Justice AC. HIV and aging: time for a new paradigm. Curr HIV/AIDS Rep. 2010;7:69-76.
2. Justice AC, Freiberg MS, Tracy R, et al. Does an index composed of clinical data reflect effects of inflammation, coagulation, and monocyte activation on mortality among those aging with HIV? Clin Infect Dis. 2012;54:984-994.
3. Justice AC, McGinnis KA, Skanderson M, et al. Towards a combined prognostic index for survival in HIV infection: the role of 'non-HIV' biomarkers. HIV Med. 2010;11:143-151.
4. Tate JP, Justice AC, Hughes MD, et al. An internationally generalizable risk index for mortality after one year of antiretroviral therapy. AIDS. 2013;27:563-572.
5. Akgun KM, Gordon K, Pisani M, et al. Risk factors for hospitalization and medical intensive care unit (MICU) admission among HIV-infected veterans. J Acquir Immune Defic Syndr. 2013;62:52-59.
6. Justice AC, Modur S, Tate JP, et al. Predictive Accuracy of the Veterans Aging Cohort Study index for mortality with HIV infection: a North American cross cohort analysis. J Acquir Immune Defic Syndr. 2013; 62:149-163.
7. Marconi VC, Grandits GA, Weintrob AC, et al. Outcomes of highly active antiretroviral therapy in the context of universal access to healthcare: the U.S. Military HIV Natural History Study. AIDS Res Ther. 2010;7:14.
8. Harrell FE Jr, Lee KL, Mark DB. Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med. 1996;15:361-387.
9. Harrell F. Regression Modeling Strategies With Applications to Linear Models, Logistic Regression, and Survival Analysis. New York, NY: Springer; 2001.
10. Graf E, Schmoor C, Sauerbrei W, et al. Assessment and comparison of prognostic classification schemes for survival data. Stat Med. 1999;18: 2529-2545.
11. Uno H, Tian L, Cai T, et al. A unified inference procedure for a class of measures to assess improvement in risk prediction systems with survival data. Stat Med. 2012;32:2430-2442.
12. Centers for Disease Control and Prevention. HIV Surveillance Report. Vol 22(2010). Available at: http://www.cdc.gov/hiv/topics/surveillance/ resources/reports/. Published March 2012. Accessed June 1, 2013.
13. May M, Royston P, Egger M, et al. Development and validation of a prognostic model for survival time data: application to prognosis of HIV positive patients treated with antiretroviral therapy. Stat Med. 2004; 23:2375-2398.