메뉴 건너뛰기




Volumn 28, Issue 2, 2014, Pages 411-413

Azacitidine induces profound genome-wide hypomethylation in primary myelodysplastic bone marrow cultures but may also reduce histone acetylation

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLATION; ANTIMETABOLITES, ANTINEOPLASTIC; AZACITIDINE; BONE MARROW CELLS; CELLS, CULTURED; DNA METHYLATION; EPIGENESIS, GENETIC; EPIGENOMICS; HISTONES; HUMANS; MYELODYSPLASTIC SYNDROMES;

EID: 84893799042     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2013.265     Document Type: Letter
Times cited : (17)

References (15)
  • 1
    • 62849104641 scopus 로고    scopus 로고
    • Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: A randomized, open-label, phase III study
    • Fenaux P, Mufti GJ, Hellströ m-Lindberg E, Santini V, Finelli C, Giagounidis A et al. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomized, open-label, phase III study. Lancet Oncol 2009; 10: 223-232.
    • (2009) Lancet Oncol , vol.10 , pp. 223-232
    • Fenaux, P.M.1
  • 2
    • 77949823230 scopus 로고    scopus 로고
    • Prolonged survival with improved tolerability in higher-risk myelodysplastic syndromes: Azacitidine compared with low-dose ara-C
    • Fenaux P, Gattermann N, Seymour JF, Hellströ m-Lindberg E, Mufti GJ, Duehrsen U et al. Prolonged survival with improved tolerability in higher-risk myelodysplastic syndromes: azacitidine compared with low-dose ara-C. Br J Haematol 2010; 149: 244-249.
    • (2010) Br J Haematol , vol.149 , pp. 244-249
    • Fenaux, P.1    Gattermann, N.2    Seymour, J.F.3    Hellströ M-Lindberg, E.4    Mufti, G.J.5    Duehrsen, U.6
  • 3
    • 67349200930 scopus 로고    scopus 로고
    • The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute meloid leukemia cells
    • Flotho C, Claus R, Batz C, Schneider M, Sandrock I, Ihde S et al. The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute meloid leukemia cells. Leukemia 2009; 23: 1019-1028.
    • (2009) Leukemia , vol.23 , pp. 1019-1028
    • Flotho, C.1    Claus, R.2    Batz, C.3    Schneider, M.4    Sandrock, I.5    Ihde, S.6
  • 4
    • 84864869497 scopus 로고    scopus 로고
    • 5-Azacitidine in aggressive myelodysplastic syndromes regulates chromatin structure at PU and cell differentiation capacity
    • Curik N, Burda P, Vargova K, Pospisil V, Belickova M, Vlckova P et al. 5-Azacitidine in aggressive myelodysplastic syndromes regulates chromatin structure at PU. and cell differentiation capacity. Leukemia 2012; 26: 1804-1811.
    • (2012) Leukemia , vol.26 , pp. 1804-1811
    • Curik, N.1    Burda, P.2    Vargova, K.3    Pospisil, V.4    Belickova, M.5    Vlckova, P.6
  • 5
    • 11844264545 scopus 로고    scopus 로고
    • Induction of gene expression by 5-Aza-2'-deoxycitidine in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) but not epithelial cells by DNAmethylation dependent and-independent mechanisms
    • Schmeltz K, Sattler N, Wagner M, Lü bbert M, Tamm I. Induction of gene expression by 5-Aza-2'-deoxycitidine in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) but not epithelial cells by DNAmethylation dependent and-independent mechanisms. Leukemia 2005; 19: 103-111.
    • (2005) Leukemia , vol.19 , pp. 103-111
    • Schmeltz, K.1    Sattler, N.2    Wagner, M.3    Lübbert, M.4    Tamm, I.5
  • 7
    • 74949115148 scopus 로고    scopus 로고
    • Immunomodulatory effect of 5-azacytidine (5-azaC): Potential role in the transplantation setting
    • Sánchez-Abarca LI, Gutierrez-Cosio S, Santamar?́a C, Caballero-Velazquez T, Blanco B, Herrero-Sánchez C et al. Immunomodulatory effect of 5-azacytidine (5-azaC): potential role in the transplantation setting. Blood 2010; 115: 107-121.
    • (2010) Blood , vol.115 , pp. 107-121
    • Sánchez-Abarca Li, G.1
  • 8
    • 77954688477 scopus 로고    scopus 로고
    • 5-azacytidine treatment reorganizes genomic histone modification patterns
    • Komashko VM, Farnham PJ. 5-azacytidine treatment reorganizes genomic histone modification patterns. Epigenetics 2010; 5: 229-240.
    • (2010) Epigenetics , vol.5 , pp. 229-240
    • Komashko, V.M.1    Farnham, P.J.2
  • 9
    • 70350234722 scopus 로고    scopus 로고
    • Azacytidine inhibits RNA methylation at DNMT2 target sites in human cancer cell lines
    • Schaefer M, Hagemann S, Hanna K, Lyko K. Azacytidine inhibits RNA methylation at DNMT2 target sites in human cancer cell lines. Cancer Res 2009; 69: 8127-8132.
    • (2009) Cancer Res , vol.69 , pp. 8127-8132
    • Schaefer, M.1    Hagemann, S.2    Hanna, K.3    Lyko, K.4
  • 10
    • 77954581656 scopus 로고    scopus 로고
    • Maintenance treatment with azacitidine for patients with high-risk myelodysplastic syndromes (MDS) or acute myeloid leukemia following MDS in complete remission after induction chemotherapy
    • Grö vdal M, Karimi M, Khan R, Aggerholm A, Antunovic P, Astermark J et al. Maintenance treatment with azacitidine for patients with high-risk myelodysplastic syndromes (MDS) or acute myeloid leukemia following MDS in complete remission after induction chemotherapy. Br J Haematol 2010; 150: 293-302.
    • (2010) Br J Haematol , vol.150 , pp. 293-302
    • Grövdal, M.K.1
  • 11
    • 33744918070 scopus 로고    scopus 로고
    • DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia
    • Yang AS, Doshi KD, Choi SW, Mason JB, Mannari RK, Gharybian V et al. DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia. Cancer Res 2006; 66: 5495-5503.
    • (2006) Cancer Res , vol.66 , pp. 5495-5503
    • Yang, A.S.1    Doshi, K.D.2    Choi, S.W.3    Mason, J.B.4    Mannari, R.K.5    Gharybian, V.6
  • 12
    • 66449125866 scopus 로고    scopus 로고
    • LINE-1 methylation is plasma DNA as a biomarker of activity of DNA methylation inhibition in patients with solid tumors
    • Aparicio A, North B, Barske L, Wang X, Bollati V, Weisenberger D et al. LINE-1 methylation is plasma DNA as a biomarker of activity of DNA methylation inhibition in patients with solid tumors. Epigenetics 2009; 4: 20-28.
    • (2009) Epigenetics , vol.4 , pp. 20-28
    • Aparicio, A.1    North, B.2    Barske, L.3    Wang, X.4    Bollati, V.5    Weisenberger, D.6
  • 13
    • 70350720044 scopus 로고    scopus 로고
    • MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation
    • Figueroa ME, Skrabanek L, Li Y, Fandy TE, Paietta E, Fernandez H et al. MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation. Blood 2009; 114: 3448-3458.
    • (2009) Blood , vol.114 , pp. 3448-3458
    • Figueroa, M.E.1    Skrabanek, L.2    Li, Y.3    Fandy, T.E.4    Paietta, E.5    Fernandez, H.6
  • 14
    • 84856528270 scopus 로고    scopus 로고
    • Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer
    • Hon GC, Hawkins RD, Caballero OL, Lo C, Lister R, Pelizzola M et al. Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer. Genome Res 2011; 22: 246-258.
    • (2011) Genome Res , vol.22 , pp. 246-258
    • Hon, G.C.1    Hawkins, R.D.2    Caballero, O.L.3    Lo, C.4    Lister, R.5    Pelizzola, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.