A novel class of ion displacement ligands as antagonists of the αiIbβ3 receptor that limit conformational reorganization of the receptor

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 4, 2014, Pages 1148-1153

  Jiang, Jian Kang ^a   McCoy, Joshua G ^a   Shen, Min ^a   LeClair, Christopher A ^a   Huang, Wenwei ^a   Negri, Ana ^b   Li, Jihong ^c   Blue, Robert ^c   Harrington, Amanda Weil ^c   Naini, Sarasija ^c   David III, George ^c   Choi, Won Seok ^c   Volpi, Elisabetta ^c   Fernandez, Joseph ^c   Babayeva, Mariana ^d   Nedelman, Mark A ^e   Filizola, Marta ^b   Coller, Barry S ^c   Thomas, Craig J ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

^d TOURO COLLEGE   (United States)

^e Ekam Imaging   (United States)

Author keywords

IIb 3 Integrin receptor; Ion displacement ligand; Platelet

Indexed keywords

ION DISPLACEMENT LIGAND; PLATELET; ΑIIBΒ3 INTEGRIN RECEPTOR;

BLOOD PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IONS; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84893793121     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.12.122     Document Type: Article

References (25)

1. K. Bledzka, S.S. Smyth, and E.F. Plow Circ. Res. 112 2013 1189
2. S.H. Lang, N. Manning, N. Armstrong, K. Misso, A. Allen, M. Di Nisio, and J. Kleijnen Curr. Med. Res. Opin. 28 2012 351
3. B.S. Coller, and S.J. Shatil Blood 112 2008 3011
4. R.O. Hynes Cell 110 2002 673
5. T. Xiao, J. Takagi, B.S. Coller, J.H. Wang, and T.A. Springer Nature 432 2004 59
6. B.H. Luo, C.V. Carman, and T.A. Springer Annu. Rev. Immunol. 25 2007 619
7. T.A. Springer, J. Zhu, and T. Xiao J. Cell Biol. 182 2008 791
8. J. Takagi, B.M. Petre, T. Walz, and T.A. Springer Cell 110 2002 599
9. D.W. Bougie, P.R. Wilker, E.D. Uuitschick, B.R. Curtins, M. Malik, S. Levine, R.N. Lind, J. Pereira, and R.H. Aster Blood 100 2002 2017
10. D.P. Chew, D.L. Bhatt, and E.J. Topol Am. J. Cardiovasc. Drugs 1 2001 421
11. D. Cox Curr. Pharm. Des. 10 2004 1587
12. X.P. Du, E.F. Plow, A.L. Frelinger 3rd, T.E. O'Toole, J.C. Loftus, and M.H. Ginsberg Cell 65 1991 409
13. R.R. Hantgan, and M.C. Stahle Biochemistry 48 2009 8355
14. M.L. Jones, M.T. Harper, E.W. Aitken, C.M. Williams, and A.W. Poole J. Thromb. Haemost. 8 2010 567
15. N. Bassler, C. Loeffler, P. Mangin, Y. Yuan, M. Schwarz, C.E. Hagemeyer, S.U. Eisenhadt, I. Ahrens, C. Bode, S.P. Jackson, and K. Peter Arterioscler. Thromb. Vasc. Biol. 27 2007 e9
16. R. Blue, M. Murcia, C. Karan, M. Jirousková, and B.S. Coller Blood 111 2008 1248
17. R. Blue, M.A. Kowalska, J. Hirsch, M. Murcia, C.A. Janczak, M. Harington, M. Jirousková, J. Li, R. Fuentes, M.A. Thornton, M. Filizola, M. Poncz, C. Karan, and B.S. Coller Blood 114 2009 195
18. J. Zhu, J. Zhu, A. Negri, D. Provasi, M. Filizola, B.S. Coller, and T.A. Springer Blood 116 2010 5050
19. J. Zhu, W.-S. Choi, J.G. McCoy, A. Negri, J. Zhu, S. Naini, J. Li, M. Shen, W. Huang, D. Bougie, M. Rasmussen, R. Aster, C.J. Thomas, M. Filizola, T.A. Springer, and B.S. Coller Sci. Trans. Med. 4 2012 125ra32
20. M.J. Frisch, G.W. Trucks, H.B. Schlegel, G.E. Scuseria, M.A. Robb, J.R. Cheeseman, J.A.J. Montgomery, T. Vreven, K.N. Kudin, J.C. Burant, J.M. Millam, S.S. Iyengar, J. Tomasi, V. Barone, B. Mennucci, M. Cossi, G. Scalmani, N. Rega, G.A. Petersson, H. Nakatsuji, M. Hada, M. Ehara, K. Toyota, R. Fukuda, J. Hasegawa, M. Ishida, T. Nakajima, Y. Honda, O. Kitao, H. Nakai, M. Klene, X. Li, J.E. Knox, H.P. Hratchian, J.B. Cross, V. Bakken, C. Adamo, J. Jaramillo, R. Gomperts, R.E. Stratmann, O. Yazyev, A.J. Austin, R. Cammi, C. Pomelli, J.W. Ochterski, P.Y. Ayala, K. Morokuma, G.A. Voth, P. Salvador, J.J. Dannenberg, V.G. Zakrzewski, S. Dapprich, A.D. Daniels, M.C. Strain, O. Farkas, D.K. Malick, A.D. Rabuck, K. Raghavachari, J.B. Foresman, J.V. Ortiz, Q. Cui, A.G. Baboul, S. Clifford, J. Cioslowski, B.B. Stefanov, G. Liu, A. Liashenko, P. Piskorz, I. Komaromi, R.L. Martin, D.J. Fox, T. Keith, M.A. Al-Laham, C.Y. Peng, A. Nanayakkara, M. Challacombe, P.M.W. Gill, B. Johnson, W. Chen, M.W. Wong, C. Gonzalez, and J.A. Pople Gaussian 03, Revision C.02 2004 Gaussian Wallingford, CT
21. http://ambermd.org/.
22. G. DE Luca, F. Bellandi, K. Huber, M. Noc, A.S. Petronio, H.R. Arntz, M. Maioli, H.M. Gabriel, S. Zorman, M. DE Carlo, T. Rakowski, M. Gyongyosi, and D. Dudek J. Thromb. Haemost. 9 2011 2361
23. Q. Xu, J. Yin, and L.Y. Si Int. J. Cardiol. 162 2013 210
24. A.K. Hassan, S.S. Liem, F. van der Kley, S.C. Bergheanu, R. Wolterbeek, J. Bosch, M. Bootsma, K. Zeppenfeld, A. van der Laarse, D.E. Atsma, J.W. Jukema, and M.J. Schalij Catheter. Cardiovasc. Interv. 74 2009 335
25. N. Anderson, and J. Borlak FEBS Lett. 580 2006 5533