Leukemic evolution of donor-derived cells harboring IDH2 and DNMT3A mutations after allogeneic stem cell transplantation

Leukemia

Volumn 28, Issue 2, 2014, Pages 426-428

  Yasuda, T ^a,b   Ueno, T ^a   Fukumura, K ^a   Yamato, A ^a   Ando, M ^a   Yamaguchi, H ^a   Soda, M ^a   Kawazu, M ^b   Sai, E ^a   Yamashita, Y ^b   Murata, M ^a   Kiyoi, H ^b   Naoe, T ^b,c   Mano, H ^a,d  

^a UNIVERSITY OF TOKYO   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c NATIONAL HOSPITAL ORGANIZATION NAGOYA MEDICAL CENTER   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA (CYTOSINE-5-)-METHYLTRANSFERASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; ISOCITRATE DEHYDROGENASE; LEUKEMIA; MALE; MIDDLE AGED; MUTATION; TISSUE DONORS; TRANSPLANTATION, HOMOLOGOUS;

EID: 84893779565     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2013.278     Document Type: Letter

References (11)

1. Fialkow PJ, Thomas ED, Bryant JI, Neiman PE. Leukaemic transformation of engrafted human marrow cells in vivo. Lancet 1971; 1: 251-255.
2. Wiseman DH. Donor cell leukemia: a review. Biol Blood Marrow Transplant 2011; 17: 771-789.
3. Murata M, Ishikawa Y, Ohashi H, Terakura S, Ozeki K, Kiyoi H et al. Donor cell leukemia after allogeneic peripheral blood stem cell transplantation: a case report and literature review. Int J Hematol 2008; 88: 111-115.
4. Kubonishi I, Miyoshi I. Establishment of a Ph1 chromosome-positive cell line from chronic myelogenous leukemia in blast crisis. Int J Cell Cloning 1983; 1: 105-117.
5. Prior IA, Lewis PD, Mattos C. A comprehensive survey of Ras mutations in cancer. Cancer Res 2012; 72: 2457-2467.
6. Birch JM, Alston RD, McNally RJ, Evans DG, Kelsey AM, Harris M et al. Relative frequency and morphology of cancers in carriers of germline TP53 mutations. Oncogene 2001; 20: 4621-4628.
7. Sala-Torra O, Hanna C, Loken MR, Flowers ME, Maris M, Ladne PA et al. Evidence of donor-derived hematologic malignancies after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2006; 12: 511-517.
8. Busque L, Patel JP, Figueroa ME, Vasanthakumar A, Provost S, Hamilou Z et al. Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis. Nat Genet 2012; 44: 1179-1181.
9. Jan M, Snyder TM, Corces-Zimmerman MR, Vyas P, Weissman IL, Quake SR et al. Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia. Sci Transl Med 2012; 4: 149ra118.
10. Wakita S, Yamaguchi H, Omori I, Terada K, Ueda T, Manabe E et al. Mutations of the epigenetics-modifying gene (DNMT3a, TET2, IDH1/2) at diagnosis may induce FLT3-ITD at relapse in de novo acute myeloid leukemia. Leukemia 2013; 27: 1044-1052.
11. Network TCGAR. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med 2013; 368: 2059-2074.