New class of azaheptapyridine FPT inhibitors as potential cancer therapy agents

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 4, 2014, Pages 1228-1231

  Zhu, Hugh Y ^a   Desai, Jagdish ^a   Cooper, Alan B ^a   Wang, James ^a   Rane, Dinananth F ^a   Kirschmeier, Paul ^a   Strickland, Corey ^a   Liu, Ming ^a   Nomeir, Amin A ^a   Girijavallabhan, Viyyoor M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

FPT inhibitors

Indexed keywords

FPT INHIBITORS;

ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTINEOPLASTIC AGENTS; AZA COMPOUNDS; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HAPLORHINI; HUMANS; MICE; MICE, TRANSGENIC; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEOPLASMS, EXPERIMENTAL; PYRIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84893750386     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.12.046     Document Type: Article

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