Discovery of C-imidazole azaheptapyridine FPT inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 3, 2010, Pages 1134-1136

  Zhu, Hugh Y ^a   Cooper, Alan B ^a   Desai, Jagdish ^a   Njoroge, George ^a   Kirschmeier, Paul ^a   Bishop, W Robert ^a   Strickland, Corey ^a   Hruza, Alan ^a   Doll, Ronald J ^a   Girijavallabhan, Viyyoor M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

FPT inhibitors

Indexed keywords

3 BENZYL 7 CYANO 2,3,4,5 TETRAHYDRO 1 (1H IMIDAZOL 4 YLMETHYL) 4 (2 THIENYLSULFONYL) 1H 1,4 BENZODIAZEPINE; C IMIDAZOLE AZAHEPTAPYRIDINE; IMIDAZOLE; IMIDAZOLE DERIVATIVE; JANSSEN R 115777; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PYRIDINE DERIVATIVE; TRANSCRIPTION FACTOR ERG; UNCLASSIFIED DRUG; ZINC; FARNESYL TRANS TRANSFERASE;

ARTICLE; ATOM; CATALYSIS; CROSS LINKING; CRYSTAL STRUCTURE; DIASTEREOISOMER; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; PROTEIN INTERACTION; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; CHEMISTRY; COMPARATIVE STUDY; DRUG DEVELOPMENT; METABOLISM; PROCEDURES; TUMOR CELL LINE;

CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; FARNESYLTRANSTRANSFERASE; HUMANS; IMIDAZOLES; PYRIDINES;

EID: 74049104089     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.12.013     Document Type: Article

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