Preoperative chemoradiation with or without induction oxaliplatin plus 5-fluorouracil in locally advanced rectal cancer: Long-term outcome analysis

Strahlentherapie und Onkologie

Volumn 190, Issue 2, 2014, Pages 149-157

  Calvo, F A ^a,b   Sole, C V ^a,b,c   Serrano, J ^a,b   Del Valle, E ^a   Rodriguez, M ^a   Munoz Calero A ^a,b   Garcia Sabrido J L ^a,b   Garcia Alfonso, P ^a,b   Peligros, I ^a   Alvarez, E ^a,b  

^a HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c Instituto de Radiomedicina Santiago   (Chile)

Author keywords

External beam radiation therapy; FOLFOX 4; Locally advanced rectal cancer; Long term outcomes; Neoadjuvant oxaliplatin

Indexed keywords

FLUOROURACIL; FOLINIC ACID; OXALIPLATIN; TEGAFUR;

ACUTE TOXICITY; ADULT; ADVANCED CANCER; AGED; ANUS SPHINCTER; ARTICLE; BLADDER INJURY; CANCER COMBINATION CHEMOTHERAPY; CANCER CONTROL; CANCER LOCALIZATION; CANCER REGRESSION; CANCER SPECIFIC SURVIVAL; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CHEMORADIOTHERAPY; CHRONIC TOXICITY; CONTINUOUS INFUSION; DISEASE FREE SURVIVAL; DISTANT METASTASIS FREE SURVIVAL; EXTERNAL BEAM RADIOTHERAPY; FEASIBILITY STUDY; FEMALE; FISTULA; FOLLOW UP; GASTROINTESTINAL TOXICITY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INDUCTION CHEMOTHERAPY; INTESTINE INJURY; INTRAOPERATIVE RADIOTHERAPY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MULTIPLE CYCLE TREATMENT; NEUROTOXICITY; OUTCOME ASSESSMENT; PERFORATION; PEROPERATIVE COMPLICATION; PREOPERATIVE CARE; PREOPERATIVE RADIOTHERAPY; RADIATION DOSE; RECTUM CANCER; RECTUM INJURY; SKIN TOXICITY; SMALL INTESTINE OBSTRUCTION; UROGENITAL TRACT DISEASE; VERY ELDERLY; WOUND DEHISCENCE; WOUND INFECTION;

ADULT; AGED; AGED, 80 AND OVER; ANAL CANAL; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHEMORADIOTHERAPY; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; FEASIBILITY STUDIES; FEMALE; FLUOROURACIL; FOLLOW-UP STUDIES; HUMANS; LEUCOVORIN; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM STAGING; ORGAN SPARING TREATMENTS; ORGANOPLATINUM COMPOUNDS; RECTAL NEOPLASMS; TREATMENT OUTCOME;

EID: 84893749379     PISSN: 01797158     EISSN: 1439099X     Source Type: Journal    
DOI: 10.1007/s00066-013-0469-0     Document Type: Article

References (24)

1. Sauer R, Liersch T, Merkel S et al (2012) Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years. J Clin Oncol 30:1926-1933
2. Gijn W van, Marijnen CA, Nagtegaal ID et al (2011) Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial. Lancet Oncol 12:575-582
3. Guckenberger M, Saur G, Wehner D et al (2012) Comparison of preoperative short course radiotherapy and long-course radiochemotherapy for locally advanced rectal cancer. Strahlenther Onkol 188:551-557
4. Sautter-Bihl ML, Hohenberger W, Fietkau R et al (2013) Rectal cancer: when is the local recurrence risk low enough to refrain from the aim to prevent it? Strahlenther Onkol 189:105-110
5. Sauer R, Becker H, Hohenberger W et al (2004) Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351:1731-1740
6. Bujko K, Nowacki MP, Nasierowska-Guttmejer A et al (2004) Sphincter preservation following preoperative radiotherapy for rectal cancer: report of a randomised trial comparing short-term radiotherapy vs. conventionally fractionated radiochemotherapy. Radiother Oncol 72:15-24
7. Gerard JP, Azria D, Gourgou-Bourgade S et al (2010) Comparison of two neoadjuvant chemoradiotherapy regimens for locally advanced rectal cancer: results of the phase III trial ACCORD 12/0405-Prodige 2. J Clin Oncol 28:1638-1644
8. Rödel C, Liersch T, Becker H et al (2012) Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial. Lancet Oncol 13:679-687
9. Calvo FA, Serrano FJ, Diaz-González JA et al (2006) Improved incidence of pT0 downstaged surgical specimens in locally advanced rectal cancer (LARC) treated with induction oxaliplatin plus 5-fluorouracil and preoperative chemoradiation. Ann Oncol 17:1103-1110
10. Quirke P, Durdey P, Dixon MF, Williams NS (1986) Local recurrence of rectal adenocarcinoma due to inadequate surgical resection, histopathological study of lateral tumor spread and surgical excision. Lancet 2:996-999
11. American Joint Committee on Cancer (2007) General information on cancer staging and end-results reporting. In: Cancer staging handbook, 7th edn. Springer, Heidelberg, pp 1-39
12. Rodel C, Martus P, Papadoupolos T et al (2005) Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer. J Clin Oncol 23:8688-8696
13. Crane CH, Skibber JM, Feig BW et al (2003) Response to preoperative chemoradiation increase the use of sphincter preserving surgery in patients with locally advanced low rectal carcinoma. Cancer 97:517-524
14. Glehen O, Chapet O, Adham M et al (2003) Long-term results of the Lyons R90-01 randomized trail of preoperative radiotherapy and delayed surgery and its effect on sphincter-saving surgery in rectal cancer. Br J Surg 90:996-998
15. Jakobsen A, Ploen J, Vuong T et al (2012) Dose-effect relationship in chemoradiotherapy for locally advanced rectal cancer: a randomized trial comparing two radiation doses. Int J Radiat Oncol Biol Phys 84:949-954
16. Gerard JP, Chapet O, Nemoz C et al (2004) Improved sphincter preservation in low rectal cancer with high-dose preoperative radiotherapy: the Lyon R96-02 randomized trial. J Clin Oncol 22:2404-2409
17. Glynne-Jones R, Grainger J, Harrison M et al (2006) Neoadjuvant chemotherapy prior to preoperative chemoradiation or radiation in rectal cancer: should we be more cautious? Br J Cancer 94:363-371
18. Chua YJ, Barbachano Y, Cunningham D et al (2010) Neoadjuvant capecitabine and oxaliplatin before chemoradiotherapy and total mesorectal excision in MRI defined poor-risk rectal cancer: a phase 2 trial. Lancet Oncol 11:241-248
19. Rödel C, Arnold D, Becker H et al (2010) Induction chemotherapy before chemoradiotherapy and surgery for locally advanced rectal cancer: is it time for a randomized phase III trial? Strahlenther Onkol 186:658-664
20. Fernandez-Martos C, Pericay C, Aparicio J et al (2010) Phase II, randomized study of concomitant chemoradiotherapy followed by surgery and adjuvant capecitabine plus oxaliplatin (CAPOX) compared with induction CAPOX followed by concomitant chemoradiotherapy and surgery in magnetic resonance imaging-defined, locally advanced rectal cancer: Grupo cancer de recto 3 study. J Clin Oncol 28:859-865
21. Maréchal R, Vos B, Polus M et al (2012) Short course chemotherapy followed by concomitant chemoradiotherapy and surgery in locally advanced rectal cancer: a randomized multicentric phase II study. Ann Oncol 23:1525-1530
22. Roh MS, Colangelo LH, O'Connell MJ et al (2009) Preoperative multimodality therapy improves disease-free survival in patients with carcinoma of the rectum: NSABP R-03. J Clin Oncol 27:5124-5130
23. Bujko K, Richter P, Smith FM et al (2013) Preoperative radiotherapy and local excision of rectal cancer with immediate radical re-operation for poor responders: a prospective multicentre study. Radiother Oncol 106:198-205
24. Glynne-Jones R, Anyamene N, Moran B, Harrison M (2012) Neoadjuvant chemotherapy in MRI-staged high-risk rectal cancer in addition to or as an alternative to preoperative chemoradiation? Ann Oncol 23:2517-2526