Induction chemotherapy before chemoradiotherapy and surgery for locally advanced rectal cancer: Is it time for a randomized phase III trial?

Strahlentherapie und Onkologie

Volumn 186, Issue 12, 2010, Pages 658-664

  Rödel, Claus ^a   Arnold, Dirk ^b   Becker, Heinz ^c   Fietkau, Rainer ^d   Ghadimi, Michael ^c   Graeven, Ullrich ^e   Hess, Clemens ^c   Hofheinz, Ralf ^f   Hohenberger, Werner ^g   Post, Stefan ^f   Raab, Rudolf ^h   Sauer, Rolf ^d   Wenz, Frederick ^f   Liersch, Torsten ^c  

^a GOETHE UNIVERSITY   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

^d UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^e KLINIKEN MARIA HILF GMBH   (Germany)

^f UNIVERSITY OF HEIDELBERG   (Germany)

^g UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^h KLINIKUM OLDENBURG   (Germany)

Author keywords

Chemoradiotherapy; Induction chemotherapy; Rectal cancer

Indexed keywords

BEVACIZUMAB; CAPECITABINE; FLUOROURACIL; FOLINIC ACID; MITOMYCIN C; OXALIPLATIN; TEGAFUR;

ADVANCED CANCER; ANASTOMOSIS LEAKAGE; ARTICLE; BIBLIOGRAPHIC DATABASE; CANCER CHEMOTHERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURGERY; COLITIS; CONTINUOUS INFUSION; DIARRHEA; DISEASE FREE SURVIVAL; DRUG EFFICACY; HEART FAILURE; HEART INFARCTION; HUMAN; INFECTION; INTESTINE PERFORATION; LUNG EMBOLISM; MEDLINE; MULTIMODALITY CANCER THERAPY; MULTIPLE CYCLE TREATMENT; MULTIPLE ORGAN FAILURE; NEUTROPENIC COLITIS; NEUTROPENIC SEPSIS; OVERALL SURVIVAL; POSTOPERATIVE COMPLICATION; PREOPERATIVE RADIOTHERAPY; RADIATION DOSE; RECTUM CANCER; SEPSIS; SMALL INTESTINE OBSTRUCTION; TREATMENT REFUSAL; TREATMENT RESPONSE; TUMOR REGRESSION;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHEMOTHERAPY, ADJUVANT; CLINICAL TRIALS, PHASE II AS TOPIC; CLINICAL TRIALS, PHASE III AS TOPIC; COMBINED MODALITY THERAPY; DISEASE PROGRESSION; FEASIBILITY STUDIES; FLUOROURACIL; HUMANS; NEOADJUVANT THERAPY; NEOPLASM STAGING; RADIOTHERAPY, ADJUVANT; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RECTAL NEOPLASMS; RECTUM;

EID: 79951681074     PISSN: 01797158     EISSN: 1439099X     Source Type: Journal    
DOI: 10.1007/s00066-010-2194-2     Document Type: Article

References (37)

1. Aschele C, Pinto C, Cordio S, et al. Preoperative fluorouracil (FU)-based chemoradiation with and without weekly oxaliplatin in locally advanced rectal cancer: Pathologic response analysis of the Studio Terapia Adiuvante Retto (STAR)-01 randomized phase III trial. J Clin Oncol (Meeting Abstracts) 2009;27:CRA4008.
2. Bosset JF, Collette L, Calais G, et al. Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med 2006;355:1114-23. (Pubitemid 44394918)
3. Bujko K, Glynne-Jones R, Bujko M. Does adjuvant fluoropyrimidine-based chemotherapy provide a benefit for patients with resected rectal cancer who have already received neoadjuvant radiochemotherapy? A systematic review of randomised trials. Ann Oncol 2010, epub ahead of print.
4. Burton S, Brown G, Daniels IR, et al. MRI directed multidisciplinary team preoperative treatment strategy: the way to eliminate positive circumferential margins? Br J Cancer 2006;94:351-7. (Pubitemid 43237559)
5. Calvo FA, Serrano FJ, Diaz-Gonzalez JA, et al. Improved incidence of pTO downstaged surgical specimens in locally advanced rectal cancer (LARC) treated with induction oxaliplatin plus 5-fluorouracil and preoperative chemoradiation. Ann Oncol 2006;17:1103-10 (Pubitemid 43985246)
6. Chau I, Allen M, Cunningham D, et al. Neoadjuvant systemic fluorouracil and mitomycin C prior to synchronous chemoradiation is an effective strategy in locally advanced rectal cancer. Br J Cancer 2003;88:1017-24. (Pubitemid 36560768)
7. Chau I, Brown G, Cunningham D, et al. Neoadjuvant capecitabine and oxaliplatin followed by synchronous chemoradiation and total mesorectal excision in magnetic resonance imaging-defined poor-risk rectal cancer. J Clin Oncol 2006;24:668-74. (Pubitemid 46630432)
8. Chua YJ, Barbachano Y, Cunningham D, et al. Neoadjuvant capecitabine and oxaliplatin before chemoradiotherapy and total mesorectal excision in MRIdefined poor-risk rectal cancer: a phase 2 trial. Lancet Oncol 2010;11:241-8.
9. Collette L, Bosset JF, den Dulk M, et al. Patients with curative resection of cT3-4 rectal cancer after preoperative radiotherapy or radiochemotherapy: does anybody benefit from adjuvant fluorouracil-based chemotherapy? A trial of the European Organisation for Research and Treatment of Cancer Radiation Oncology Group. J Clin Oncol 2007;25:4379-86. (Pubitemid 350013843)
10. Fernandez-Martos C, Pericay C, Aparicio J, et al. Phase II, randomized study of concomitant chemoradiotherapy followed by surgery and adjuvant capecitabine plus oxaliplatin (CAPOX) compared with induction CAPOX followed by concomitant chemoradiotherapy and surgery in magnetic resonance imaging-defined, locally advanced rectal cancer: Grupo cancer de recto 3 study. J Clin Oncol 2010;28:859-65.
11. Fernandez-Martos C, Safont M, Feliu J, et al. Induction chemotherapy with or without chemoradiation in intermediate-risk rectal cancer patients defined by magnetic resonance imaging (MRI): A GEMCAD study. J Clin Oncol (Meeting Abstracts) 2010;28:TPS196.
12. Garcia-Aguilar J, Shi Q, Thomas CR, Jr., et al. Pathologic complete response (pCR) to neoadjuvant chemoradiation (CRT) of uT2uN0 rectal cancer (RC) treated by local excision (LE): Results of the ACOSOG Z6041 trial. J Clin Oncol (Meeting Abstracts) 2010;28:3510.
13. Gerard JP, Azria D, Gourgou-Bourgade S, et al. Comparison of two neoadjuvant chemoradiotherapy regimens for locally advanced rectal cancer: results of the phase III trial ACCORD 12/0405-Prodige 2. J Clin Oncol 2010;28:1638-44.
14. Ghadimi BM, Grade M, Difilippantonio MJ, et al. Effectiveness of gene expression profiling for response prediction of rectal adenocarcinomas to preoperative chemoradiotherapy. J Clin Oncol 2005;23:1826-38. (Pubitemid 46217459)
15. Glynne-Jones R, Grainger J, Harrison M, et al. Neoadjuvant chemotherapy prior to preoperative chemoradiation or radiation in rectal cancer: should we be more cautious? Br J Cancer 2006;94:363-71. (Pubitemid 43237561)
16. Gunnlaugsson A, Anderson H, Fernebro E, et al. Multicentre phase II trial of capecitabine and oxaliplatin in combination with radiotherapy for unresectable colorectal cancer: the CORGI-L Study. Eur J Cancer 2009;45:807-13.
17. Habr-Gama A, Perez RO, Nadalin W, et al. Operative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy: long-term results. Ann Surg 2004;240:711-7; discussion 7-8.
18. Koeberle D, Burkhard R, von Moos R, et al. Phase II study of capecitabine and oxaliplatin given prior to and concurrently with preoperative pelvic radiotherapy in patients with locally advanced rectal cancer. Br J Cancer 2008;98:1204-9. (Pubitemid 351481682)
19. Liersch T, Grade M, Gaedcke J, et al. Preoperative chemoradiotherapy in locally advanced rectal cancer: correlation of a gene expression-based response signature with recurrence. Cancer Genet Cytogenet 2009;190:57-65.
20. Marechal R, Vos B, Polus M, et al. Chemotherapy induction followed by preoperative chemoradiation versus preoperative chemoradiation alone in locally advanced rectal cancer (LARC): A randomized controlled phase II study. J Clin Oncol (Meeting Abstracts) 2010;28:3637.
21. Marquardt F, Rodel F, Capalbo G, et al. Molecular targeted treatment and radiation therapy for rectal cancer. Strahlenther Onkol 2009;185:371-8.
22. Minsky BD, Roedel C, Valentini V. Combined modality therapy for rectal cancer. Cancer J 2010;16:253-61.
23. Ngan S, Fisher R, Goldstein D, et al. A randomized trial comparing local recurrence (LR) rates between short-course (SC) and long-course (LC) preoperative radiotherapy (RT) for clinical T3 rectal cancer: An intergroup trial (TROG, AGITG, CSSANZ, RACS). J Clin Oncol (Meeting Abstracts) 2010;28:3509.
24. Palman L, Glimelius B. Pre- or postoperative radiotherapy in rectal and rectosigmoid carcinoma. Report from a randomized multicenter trial. Ann Surg 1990, 211: 187-95. (Pubitemid 20063206)
25. Paskeviciute B, Bolling T, Brinkmann M, et al. Impact of (18)F-FDG-PET/CT on staging and irradiation of patients with locally advanced rectal cancer. Strahlenther Onkol 2009;185:260-5.
26. Quasar Collaborative G, Gray R, Barnwell J, et al. Adjuvant chemotherapy versus observation in patients with colorectal cancer: a randomised study. Lancet 2007;370:2020-9.
27. Rael C, Liersch T, Hermann RM, et al. Multicenter phase II trial of chemoradiation with oxaliplatin for rectal cancer. J Clin Oncol 2007, 25: 110-7. (Pubitemid 350003058)
28. Rael C, Sauer R. Integration of novel agents into combined-modality treatment for rectal cancer patients. Strahlenther Onkol 2007, 183: 227-35. (Pubitemid 46725993)
29. Rael C, Sauer R, Fietkau R. The role of magnetic resonance imaging to select patients for preoperative treatment in rectal cancer. Strahlenther Onkol 2009;185:488-92.
30. Roh MS, Colangelo LH, O?Connell MJ, et al. Preoperative multimodality therapy improves disease-free survival in patients with carcinoma of the rectum: NSABP R-03. J Clin Oncol 2009;27:5124-30.
31. Rutten H, Sebag-Montefiori D, Glynne-Jones R, et al. Capecitabine, oxaliplatin, radiotherapy, and excision (CORE) in patients with MRI-defined locally advanced rectal adenocarcinoma: Results of an international multicenter phase II study. J Clin Oncol (Meeting abstracts) 2006;24:153s.
32. Sauer R, Becker H, Hohenberger W, et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 2004;351:1731-40.
33. Schmiegel W, Pox C, Reinacher-Schick A, et al. S3 guidelines for colorectal carcinoma: results of an evidence-based consensus conference on February 6/7, 2004 and June 8/9, 2007 (for the topics IV, VI and VII). Z Gastroenterol 2010;48:65-136.
34. Schrag D, Weiser MR, Goodman KA, et al. Neoadjuvant FOLFOX-bev, without radiation, for locally advanced rectal cancer. J Clin Oncol (Meeting Abstracts) 2010;28:3511.
35. Valentini V, Aristei C, Glimelius B, et al. Multidisciplinary Rectal Cancer Management: 2nd European Rectal Cancer Consensus Conference (EURECACC2). Radiother Oncol 2009;92:148-63.
36. van Dijk TH, Havenga K, Beukema J, et al. Short-course radiation therapy, neoadjuvant bevacizumab, capecitabine and oxaliplatin, and radical resection of primary tumor and metastases in primary stage IV rectal cancer: A phase II multicenter study of the Dutch Colorectal Cancer Group. J Clin Oncol (Meeting abstracts) 2010;28:3638.
37. Vliegen RF, Beets-Tan RG, Vanhauten B, et al. Can an FDG-PET/CT predict tumor clearance of the mesorectal fascia after preoperative chemoradiation of locally advanced rectal cancer? Strahlenther Onkol 2008;184:457-64.