Coeliac disease in 2013: New insights in dietary-gluten-induced autoimmunity

Nature Reviews Gastroenterology and Hepatology

Volumn 11, Issue 2, 2014, Pages 80-82

  Kaukinen, Katri ^a   Mäki, Markku ^a  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; GLUTEN; HLA DQ2 ANTIGEN; HLA DQ8 ANTIGEN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2;

AUTOIMMUNITY; BREAST FEEDING; CELIAC DISEASE; DIETARY COMPLIANCE; GLUTEN FREE DIET; HUMAN; INFANT FEEDING; INTESTINE BIOPSY; INTESTINE VILLUS ATROPHY; INTRAUTERINE GROWTH RETARDATION; LOW BIRTH WEIGHT; PLACENTA WEIGHT; REVIEW; SMALL INTESTINE MUCOSA;

AGE FACTORS; AUTOANTIBODIES; AUTOIMMUNITY; CELIAC DISEASE; DIET, GLUTEN-FREE; GLUTENS; HUMANS; INTESTINES;

EID: 84893748734     PISSN: 17595045     EISSN: 17595053     Source Type: Journal    
DOI: 10.1038/nrgastro.2013.232     Document Type: Review

References (10)

1. Mki, M. Coeliac disease and autoimmunity due to unmasking of cryptic epitopes? Lancet 348, 1046-1047 (1996).
2. Simon-Vescei, Z. et al. A single conformational transglutaminase 2 epitope contributed by three domains is critical for celiac antibody binding and effects. Proc. Natl Acad. Sci. USA 109, 431-436 (2012).
3. Di Niro, R. et al. High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesion. Nat. Med. 18, 441-445 (2012).
4. Ivarsson, A. et al. Prevalence of childhood celiac disease and changes in infant feeding. Pediatrics 131, e687-e694 (2013).
5. Sjöberg, V. et al. Intestinal T-cell responses in celiac disease-impact of celiac disease associated bacteria. PLoS ONE 8, e53414 (2013).
6. Kiefte-de Jong, J. C. et al. Levels of autoantibodies against tissue transglutaminase during pregnancy are associated with reduced fetal weight and birth weight. Gastroenterology 144, 726-735 (2013).
7. Kalliokoski, S. et al. Celiac disease-specific TG2-Targeted autoantibodies inhibit angiogenesis ex vivo and in vivo in mice by interfering with endothelial cell dynamics. PLoS ONE 8, e65887 (2013).
8. Iversen, R. et al. Transglutaminase 2-specific autoantibodies in celiac disease target clustered, N-Terminal epitopes not displayed on the surface of cells. J. Immunol. 190, 5981-5991 (2013).
9. Lebwohl, B. et al. Mucosal healing and risk for lymphoproliferative malignancy in celiac disease. A population based cohort study. Ann. Intern. Med. 159, 169-175 (2013).
10. Kaukinen, K. et al. Advances in the treatment of coeliac disease: an immunopathogenetic perspective. Nat. Rev. Gastroenterol. Hepatol. http://dx.doi.org/10.1038/nrgastro.2013.141.