The PDZ-binding motif of Yes-associated protein is required for its co-activation of TEAD-mediated CTGF transcription and oncogenic cell transforming activity

Biochemical and Biophysical Research Communications

Volumn 443, Issue 3, 2014, Pages 917-923

  Shimomura, Tadanori ^a   Miyamura, Norio ^a   Hata, Shoji ^a   Miura, Ryota ^a   Hirayama, Jun ^a   Nishina, Hiroshi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

CTGF; Hippo pathway; TEAD; YAP

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; PDZ PROTEIN; PROTEIN KINASE YES; UNCLASSIFIED DRUG; YES ASSOCIATED PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL CULTURE; CELL LYSATE; CELL PROLIFERATION; CELL TRANSFORMATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; MOUSE; NONHUMAN; NUCLEAR IMPORT; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; TRANSIENT EXPRESSION;

CONNECTIVE TISSUE GROWTH FACTOR; CTGF; HIPPO PATHWAY; TAZ; TEA DOMAIN FAMILY MEMBER; TEAD; TRANSCRIPTIONAL CO-ACTIVATOR WITH PDZ-BINDING MOTIF; YAP; YES-ASSOCIATED PROTEIN;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID MOTIFS; ANIMALS; CELL NUCLEUS; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CONNECTIVE TISSUE GROWTH FACTOR; DNA-BINDING PROTEINS; HEK293 CELLS; HUMANS; LIVER; MICE; MICE, INBRED C57BL; NIH 3T3 CELLS; NUCLEAR LOCALIZATION SIGNALS; ONCOGENES; PHOSPHOPROTEINS; PROTEIN BINDING; PROTEIN TRANSPORT; SEQUENCE DELETION; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 84893710162     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.12.100     Document Type: Article

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