Cellular uptake of 9-hydroxypheophorbide-α and its photoactivation to induce ER stress-related apoptosis in human cervical cancer cells

Lasers in Medical Science

Volumn 29, Issue 1, 2014, Pages 289-299

  Ahn, Jin Chul ^a   Biswas, Raktim ^a   Moon, Jeong Hwan ^a   Chung, Phil Sang ^a  

^a Dankook University   (South Korea)

Author keywords

9 HPbD ; Apoptosis; Endoplasmic reticulum; Intracellular localization; PDT

Indexed keywords

9 HYDROXYPHEOPHORBIDE ALPHA; CASPASE 12; CASPASE 3; PHEOPHORBIDE; PHOTOSENSITIZING AGENT; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CANCER CELL; CELL DEATH; CELL VIABILITY; CELLULAR DISTRIBUTION; CELLULAR PARAMETERS; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; ENDOPLASMIC RETICULUM STRESS; HELA CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; PHOTOACTIVATION; PHOTODYNAMIC THERAPY; PHOTODYNAMICS; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SPECTROFLUOROMETRY; TRANSMISSION ELECTRON MICROSCOPY; UTERINE CERVIX CANCER; UTERINE CERVIX CARCINOMA;

APOPTOSIS; BIOLOGICAL TRANSPORT, ACTIVE; CALCIUM; CASPASE 12; CASPASE 3; CHLOROPHYLL; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; FEMALE; HELA CELLS; HUMANS; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS;

EID: 84893709361     PISSN: 02688921     EISSN: 1435604X     Source Type: Journal    
DOI: 10.1007/s10103-013-1331-4     Document Type: Article

References (20)

1. Gomer CJ, Rucker N, Ferrario A, Wong S (1989) Properties and applications of photodynamic therapy. Radiat Res 120(1):1-18
2. Pass HI (1993) Photodynamic therapy in oncology: mechanisms and clinical use. Journal of the National Cancer Institute 85(6):443-456. doi: 10.1093/jnci/85.6.443
3. Dougherty TJ, Gomer CJ, Henderson BW, Jori G, Kessel D, Korbelik M, Moan J, Peng Q (1998) Photodynamic therapy. J Natl Cancer Inst 90(12):889-905
4. Henderson BW, Dougherty TJ (1992) How does photodynamic therapy work? Photochem Photobiol 55(1):145-157. doi: 10.1111/j.1751-1097.1992.tb04222.x
5. Castano AP, Demidova TN, Hamblin MR (2005) Mechanisms in photodynamic therapy: part three - photosensitizer pharmacokinetics, biodistribution, tumor localization and modes of tumor destruction. Photodiagn Photodyn Ther 2(2):91-106. doi: 10.1016/s1572-1000(05)00060-8
6. Zhou CN (1989) Mechanisms of tumor necrosis induced by photodynamic therapy. Journal of Photochemistry and Photobiology B, Biology 3(3):299-318
7. Miller GG, Brown K, Moore RB, McPhee MS, Diwu ZJ, Liu J, Huang L, Lown JW, Begg DA, Chlumecky V, Tulip J (1995) Uptake kinetics and intracellular localization of hypocrellin photosensitizers for photodynamic therapy: a confocal microscopy study. Photochem Photobiol 61(6):632-638. doi: 10.1111/j.1751-1097.1995.tb09880.x
8. Oliveira CS, Turchiello R, Kowaltowski AJ, Indig GL, Baptista MS (2011) Major determinants of photoinduced cell death: subcellular localization versus photosensitization efficiency. Free Radical Biology and Medicine 51 (4):824-833. doi: http://dx.doi.org/10.1016/j.freeradbiomed.2011.05.023
9. Chung PS, He P, Shin JI, Hwang HJ, Lee SJ, Ahn JC (2009) Photodynamic therapy with 9-hydroxypheophorbide alpha on AMC-HN-3 human head and neck cancer cells: induction of apoptosis via photoactivation of mitochondria and endoplasmic reticulum. Cancer Biol Ther 8(14):1343-1351
10. Choi SE, Sohn S, Cho JW, Shin EA, Song PS, Kang Y (2004) 9-Hydroxypheophorbide alpha-induced apoptotic death of MCF-7 breast cancer cells is mediated by c-Jun N-terminal kinase activation. Journal of Photochemistry and Photobiology B, Biology 73(1-2):101-107
11. He P, Ahn JC, Shin JI, Chung PS (2010) Photoactivation of 9-hydroxypheophorbide alpha triggers apoptosis through the reactive oxygen species-mediated mitochondrial pathway and endoplasmic reticulum stress in AMC-HN-3 laryngeal cancer cells. Int J Oncol 36(4):801-808
12. Chung P-S, Rhee C-K, Oh C-H, Kim H-G, Jung S-O, Ahn J-C (2003) Anticancer effect and cell cycle regulation of photodynamic therapy (PDT) using 9-hydroxypheophorbide-a and 660-nm diode laser. Proc. SPIE 4952, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XII, 198-202. doi: 10.1117/12.474152
13. Biswas D, Qureshi OS, Lee WY, Croudace JE, Mura M, Lammas DA (2008) ATP-induced autophagy is associated with rapid killing of intracellular mycobacteria within human monocytes/macrophages. BMC Immunol 9:35
14. Brunk UT, Dalen H, Roberg K, Hellquist HB (1997) Photo-oxidative disruption of lysosomal membranes causes apoptosis of cultured human fibroblasts. Free Radical Biology and Medicine 23 (4):616-626. doi: http://dx.doi.org/10.1016/S0891-5849(97)00007-5
15. Konan YN, Gurny R, Allemann E (2002) State of the art in the delivery of photosensitizers for photodynamic therapy. Journal of Photochemistry and Photobiology B, Biology 66(2):89-106
16. Moor AC (2000) Signaling pathways in cell death and survival after photodynamic therapy. Journal of Photochemistry and Photobiology B, Biology 57(1):1-13
17. Moserova I, Kralova J (2012) Role of ER stress response in photodynamic therapy: ROS generated in different subcellular compartments trigger diverse cell death pathways. PLoS One 7(3):e32972. doi: 10.1371/journal.pone.0032972
18. Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J (2000) Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403(6765):98-103. doi: 10.1038/47513
19. Rao RV, Hermel E, Castro-Obregon S, del Rio G, Ellerby LM, Ellerby HM, Bredesen DE (2001) Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation. J Biol Chem 276(36):33869-33874. doi: 10.1074/jbc.M102225200
20. Xie Q, Khaoustov VI, Chung CC, Sohn J, Krishnan B, Lewis DE, Yoffe B (2002) Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. Hepatology 36(3):592-601. doi: 10.1053/jhep.2002.35441