Effect of obesity on disease-free and overall survival in node-positive breast cancer patients in a large French population: A pooled analysis of two randomised trials

European Journal of Cancer

Volumn 50, Issue 3, 2014, Pages 506-516

  Ladoire, Sylvain ^a,b,c   Dalban, Cecile ^a   Roché, Henri ^d   Spielmann, Marc ^e   Fumoleau, Pierre ^a,c   Levy, Christelle ^f   Martin, Anne Laure ^g   Ecarnot, Fiona ^h   Bonnetain, Frank ⁱ   Ghiringhelli, François ^a,b,c  

^a CENTRE GEORGES FRANÇOIS LECLERC   (France)

^b INSERM   (France)

^c UNIVERSITÉ DE BOURGOGNE   (France)

^d INSTITUT CLAUDIUS REGAUD   (France)

^e INSTITUT GUSTAVE ROUSSY   (France)

^f CENTRE FRANÇOIS BACLESSE   (France)

^g FNCLCC   (France)

^h UNIVERSITÉ DE FRANCHE COMTÉ   (France)

ⁱ UNIVERSITY HOSPITAL OF BESANÇON   (France)

Author keywords

Adjuvant; Body mass index; Breast cancer; Prognostic factor

Indexed keywords

CYCLOPHOSPHAMIDE; DOCETAXEL; EPIRUBICIN; ESTROGEN RECEPTOR; FLUOROURACIL; PROGESTERONE RECEPTOR; TAMOXIFEN;

ADULT; ARTICLE; AXILLARY LYMPH NODE; BODY MASS; BREAST CANCER; CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER HORMONE THERAPY; CANCER PATIENT; CANCER PROGNOSIS; CANCER SURVIVAL; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; FOLLOW UP; FRANCE; HUMAN; MAJOR CLINICAL STUDY; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; MULTIPLE CYCLE TREATMENT; OBESITY; OVERALL SURVIVAL; PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); WEIGHT CHANGE;

ADJUVANT; BODY MASS INDEX; BREAST CANCER; PROGNOSTIC FACTOR;

ADULT; AGED; ANTINEOPLASTIC AGENTS, HORMONAL; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BODY MASS INDEX; BREAST NEOPLASMS; CYCLOPHOSPHAMIDE; DISEASE-FREE SURVIVAL; EPIRUBICIN; FEMALE; FLUOROURACIL; HUMANS; MIDDLE AGED; OBESITY; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; SURVIVAL ANALYSIS; TAXOIDS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84893701642     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2013.11.013     Document Type: Article

References (42)

1. World Health Organization Fact Sheet on obesity and overweight 2013 World Health Organization Geneva (accessed 07/05/2013)
2. European Commission. Overweight and obesity - BMI statistics. Data from November 2011; 2011.
3. M.A. Charles, E. Eschwege, and A. Basdevant Monitoring the obesity epidemic in France: the Obepi surveys 1997-2006 Obesity (Silver Spring) 16 9 2008 2182 2186
4. OECD. Obesity update 2012. OECD; 2011.
5. M. Boniol, and P. Autier Prevalence of main cancer lifestyle risk factors in Europe in 2000 Eur J Cancer 46 14 2010 2534 2544
6. N. Parekh, U. Chandran, and E.V. Bandera Obesity in cancer survival Annu Rev Nutr 32 2012 311 342
7. B.S. Connolly, C. Barnett, K.N. Vogt, T. Li, J. Stone, and N.F. Boyd A meta-analysis of published literature on waist-to-hip ratio and risk of breast cancer Nutr Cancer 44 2 2002 127 138
8. M. Harvie, L. Hooper, and A.H. Howell Central obesity and breast cancer risk: a systematic review Obes Rev 4 3 2003 157 173
9. S.Y. Ryu, C.B. Kim, C.M. Nam, J.K. Park, K.S. Kim, and J. Park et al. Is body mass index the prognostic factor in breast cancer?: a meta-analysis J Korean Med Sci 16 5 2001 610 614
10. M. Protani, M. Coory, and J.H. Martin Effect of obesity on survival of women with breast cancer: systematic review and meta-analysis Breast Cancer Res Treat 123 3 2010 627 635
11. M. Ewertz, M.B. Jensen, K.A. Gunnarsdottir, I. Hojris, E.H. Jakobsen, and D. Nielsen et al. Effect of obesity on prognosis after early-stage breast cancer J Clin Oncol 29 1 2011 25 31
12. F. de Waard, R. Ramlau, Y. Mulders, T. de Vries, and S. van Waveren A feasibility study on weight reduction in obese postmenopausal breast cancer patients Eur J Cancer Prev 2 3 1993 233 238
13. F. de Waard On the nutritional etiology of breast cancer Adv Exp Med Biol 348 1993 119 122
14. F. De Waard Preventive intervention in breast cancer, but when? Eur J Cancer Prev 1 6 1992 395 399
15. A.G. Renehan, I. Soerjomataram, M. Tyson, M. Egger, M. Zwahlen, and J.W. Coebergh et al. Incident cancer burden attributable to excess body mass index in 30 European countries Int J Cancer 126 3 2010 692 702
16. M. Arnold, H.E. Karim-Kos, J.W. Coebergh, G. Byrnes, A. Antilla, and J. Ferlay et al. Recent trends in incidence of five common cancers in 26 European countries since 1988: analysis of the European Cancer Registry database Eur J Cancer 2013
17. J.J. Dignam, K. Wieand, K.A. Johnson, P. Raich, S.J. Anderson, and C. Somkin et al. Effects of obesity and race on prognosis in lymph node-negative, estrogen receptor-negative breast cancer Breast Cancer Res Treat 97 3 2006 245 254
18. M.Z. Vitolins, G.G. Kimmick, and L.D. Case BMI influences prognosis following surgery and adjuvant chemotherapy for lymph node positive breast cancer Breast J 14 4 2008 357 365
19. R.T. Chlebowski, E. Aiello, and A. McTiernan Weight loss in breast cancer patient management J Clin Oncol 20 4 2002 1128 1143
20. E. de Azambuja, W. McCaskill-Stevens, P. Francis, E. Quinaux, J.P. Crown, and M. Vicente et al. The effect of body mass index on overall and disease-free survival in node-positive breast cancer patients treated with docetaxel and doxorubicin-containing adjuvant chemotherapy: the experience of the BIG 02-98 trial Breast Cancer Res Treat 119 1 2010 145 153
21. G. Berclaz, S. Li, K.N. Price, A.S. Coates, M. Castiglione-Gertsch, and C.M. Rudenstam et al. Body mass index as a prognostic feature in operable breast cancer: the International Breast Cancer Study Group experience Ann Oncol 15 6 2004 875 884
22. J.J. Dignam, K. Wieand, K.A. Johnson, B. Fisher, L. Xu, and E.P. Mamounas Obesity, tamoxifen use, and outcomes in women with estrogen receptor-positive early-stage breast cancer J Natl Cancer Inst 95 19 2003 1467 1476
23. H. Roche, P. Fumoleau, M. Spielmann, J.L. Canon, T. Delozier, and D. Serin et al. Sequential adjuvant epirubicin-based and docetaxel chemotherapy for node-positive breast cancer patients: the FNCLCC PACS 01 Trial J Clin Oncol 24 36 2006 5664 5671
24. M. Spielmann, H. Roche, T. Delozier, J.L. Canon, G. Romieu, and H. Bourgeois et al. Trastuzumab for patients with axillary-node-positive breast cancer: results of the FNCLCC-PACS 04 trial J Clin Oncol 27 36 2009 6129 6134
25. World Health Organization Global database on body mass index 2008 World Health Organization
26. B. Majed, T. Moreau, K. Senouci, R.J. Salmon, A. Fourquet, and B. Asselain Is obesity an independent prognosis factor in woman breast cancer? Breast Cancer Res Treat 111 2 2008 329 342
27. X. Chen, W. Lu, W. Zheng, K. Gu, Z. Chen, and Y. Zheng et al. Obesity and weight change in relation to breast cancer survival Breast Cancer Res Treat 122 3 2010 823 833
28. Y. Cao Angiogenesis modulates adipogenesis and obesity J Clin Invest 117 9 2007 2362 2368
29. J. Baillargeon, and D.P. Rose Obesity, adipokines, and prostate cancer (review) Int J Oncol 28 3 2006 737 745
30. M. Ewertz, K.P. Gray, M.M. Regan, B. Ejlertsen, K.N. Price, and B. Thurlimann et al. Obesity and risk of recurrence or death after adjuvant endocrine therapy with letrozole or tamoxifen in the breast international group 1-98 trial J Clin Oncol 30 32 2012 3967 3975
31. A.M. Brewster, C. Etzel, R. Zhou, Y. Wong, S. Edge, and D.W. Blayney et al. The impact of obesity on receipt of adjuvant chemotherapy for breast cancer in the National Comprehensive Cancer Network (NCCN) centers Breast Cancer Res Treat 130 3 2011 897 904
32. J. Bastarrachea, G.N. Hortobagyi, T.L. Smith, S.W. Kau, and A.U. Buzdar Obesity as an adverse prognostic factor for patients receiving adjuvant chemotherapy for breast cancer Ann Intern Med 120 1 1994 18 25
33. Ligibel J, Cirrincione C, Citron ML, Ingle JN, Gradishar WJ, Martino S, et al. Relationship between body mass index (BMI) and outcomes in node-positive breast cancer patients receiving chemotherapy: results from CALGB/Intergroup 9741. In: Presented at the 8th European breast cancer conference. Abstract 413; 2012.
34. S. Renaud, and M. de Lorgeril Wine, alcohol, platelets, and the French paradox for coronary heart disease Lancet 339 8808 1992 1523 1526
35. T. Coutinho, K. Goel, D. Correa de Sa, C. Kragelund, A.M. Kanaya, and M. Zeller et al. Central obesity and survival in subjects with coronary artery disease: a systematic review of the literature and collaborative analysis with individual subject data J Am Coll Cardiol 57 19 2011 1877 1886
36. G. Pfeiler, R. Konigsberg, C. Fesl, B. Mlineritsch, H. Stoeger, and C.F. Singer et al. Impact of body mass index on the efficacy of endocrine therapy in premenopausal patients with breast cancer: an analysis of the prospective ABCSG-12 trial J Clin Oncol 29 19 2011 2653 2659
37. I. Sestak, W. Distler, J.F. Forbes, M. Dowsett, A. Howell, and J. Cuzick Effect of body mass index on recurrences in tamoxifen and anastrozole treated women: an exploratory analysis from the ATAC trial J Clin Oncol 28 21 2010 3411 3415
38. J.J. Griggs, M.E. Sorbero, and G.H. Lyman Undertreatment of obese women receiving breast cancer chemotherapy Arch Intern Med 165 11 2005 1267 1273
39. M. Colleoni, S. Li, R.D. Gelber, K.N. Price, A.S. Coates, and M. Castiglione-Gertsch et al. Relation between chemotherapy dose, oestrogen receptor expression, and body-mass index Lancet 366 9491 2005 1108 1110
40. J.A. Meyerhardt, D. Niedzwiecki, D. Hollis, L.B. Saltz, R.J. Mayer, and H. Nelson et al. Impact of body mass index and weight change after treatment on cancer recurrence and survival in patients with stage III colon cancer: findings from Cancer and Leukemia Group B 89803 J Clin Oncol 26 25 2008 4109 4115
41. J.A. Meyerhardt, P.J. Catalano, D.G. Haller, R.J. Mayer, A.B. Benson 3rd, and J.S. Macdonald et al. Influence of body mass index on outcomes and treatment-related toxicity in patients with colon carcinoma Cancer 98 3 2003 484 495
42. J.J. Griggs, P.B. Mangu, H. Anderson, E.P. Balaban, J.J. Dignam, and W.M. Hryniuk et al. Appropriate chemotherapy dosing for obese adult patients with cancer: American Society of Clinical Oncology clinical practice guideline J Clin Oncol 30 13 2012 1553 1561