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Volumn 5, Issue 1, 2014, Pages 89-105

The role of hypomethylating agents in the treatment of elderly patients with AML

Author keywords

Acute myeloid leukemia; Azacitidine; Decitabine; Elderly

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AZACITIDINE; CYTARABINE; DNA;

EID: 84893697515     PISSN: 18794068     EISSN: 18794076     Source Type: Journal    
DOI: 10.1016/j.jgo.2013.08.004     Document Type: Review
Times cited : (47)

References (100)
  • 1
    • 64049092296 scopus 로고    scopus 로고
    • Acute myelogenous leukemia in older adults
    • Klepin H.D., Balducci L. Acute myelogenous leukemia in older adults. Oncologist 2009, 14:222-232.
    • (2009) Oncologist , vol.14 , pp. 222-232
    • Klepin, H.D.1    Balducci, L.2
  • 2
    • 0035028824 scopus 로고    scopus 로고
    • Prognostic factors in acute myeloid leukaemia
    • Lowenberg B. Prognostic factors in acute myeloid leukaemia. Best Pract Res Clin Haematol 2001, 14:65-75.
    • (2001) Best Pract Res Clin Haematol , vol.14 , pp. 65-75
    • Lowenberg, B.1
  • 3
    • 66149148673 scopus 로고    scopus 로고
    • Age and acute myeloid leukemia: real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry
    • Juliusson G., Antunovic P., Derolf A., Lehmann S., Mollgard L., Stockelberg D., et al. Age and acute myeloid leukemia: real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry. Blood 2009, 113:4179-4187.
    • (2009) Blood , vol.113 , pp. 4179-4187
    • Juliusson, G.1    Antunovic, P.2    Derolf, A.3    Lehmann, S.4    Mollgard, L.5    Stockelberg, D.6
  • 5
    • 0036862084 scopus 로고    scopus 로고
    • The difficult problem of acute myeloid leukemia in the older adult
    • Stone R.M. The difficult problem of acute myeloid leukemia in the older adult. CA Cancer J Clin 2002, 52:363-371.
    • (2002) CA Cancer J Clin , vol.52 , pp. 363-371
    • Stone, R.M.1
  • 7
    • 0037158110 scopus 로고    scopus 로고
    • The outcomes and costs of acute myeloid leukemia among the elderly
    • Menzin J., Lang K., Earle C.C., Kerney D., Mallick R. The outcomes and costs of acute myeloid leukemia among the elderly. Arch Intern Med 2002, 162:1597-1603.
    • (2002) Arch Intern Med , vol.162 , pp. 1597-1603
    • Menzin, J.1    Lang, K.2    Earle, C.C.3    Kerney, D.4    Mallick, R.5
  • 8
    • 33947205565 scopus 로고    scopus 로고
    • A comparison of low-dose cytarabine and hydroxyurea with or without all-trans retinoic acid for acute myeloid leukemia and high-risk myelodysplastic syndrome in patients not considered fit for intensive treatment
    • Burnett A.K., Milligan D., Prentice A.G., Goldstone A.H., McMullin M.F., Hills R.K., et al. A comparison of low-dose cytarabine and hydroxyurea with or without all-trans retinoic acid for acute myeloid leukemia and high-risk myelodysplastic syndrome in patients not considered fit for intensive treatment. Cancer 2007, 109:1114-1124.
    • (2007) Cancer , vol.109 , pp. 1114-1124
    • Burnett, A.K.1    Milligan, D.2    Prentice, A.G.3    Goldstone, A.H.4    McMullin, M.F.5    Hills, R.K.6
  • 9
    • 84869458541 scopus 로고    scopus 로고
    • Boulevard of broken dreams: drug approval for older adults with acute myeloid leukemia
    • Sekeres M.A., Steensma D.P. Boulevard of broken dreams: drug approval for older adults with acute myeloid leukemia. J Clin Oncol 2012, 30:4061-4063.
    • (2012) J Clin Oncol , vol.30 , pp. 4061-4063
    • Sekeres, M.A.1    Steensma, D.P.2
  • 10
    • 51649122312 scopus 로고    scopus 로고
    • Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse
    • Kroeger H., Jelinek J., Estecio M.R., He R., Kondo K., Chung W., et al. Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse. Blood 2008, 112:1366-1373.
    • (2008) Blood , vol.112 , pp. 1366-1373
    • Kroeger, H.1    Jelinek, J.2    Estecio, M.R.3    He, R.4    Kondo, K.5    Chung, W.6
  • 11
    • 77449149373 scopus 로고    scopus 로고
    • Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia
    • Fenaux P., Mufti G.J., Hellstrom-Lindberg E., Santini V., Gattermann N., Germing U., et al. Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia. J Clin Oncol 2010, 28:562-569.
    • (2010) J Clin Oncol , vol.28 , pp. 562-569
    • Fenaux, P.1    Mufti, G.J.2    Hellstrom-Lindberg, E.3    Santini, V.4    Gattermann, N.5    Germing, U.6
  • 12
    • 33846011361 scopus 로고    scopus 로고
    • Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia
    • Kantarjian H., Oki Y., Garcia-Manero G., Huang X., O'Brien S., Cortes J., et al. Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia. Blood 2007, 109:52-57.
    • (2007) Blood , vol.109 , pp. 52-57
    • Kantarjian, H.1    Oki, Y.2    Garcia-Manero, G.3    Huang, X.4    O'Brien, S.5    Cortes, J.6
  • 13
    • 79956294708 scopus 로고    scopus 로고
    • Low-dose decitabine versus best supportive care in elderly patients with intermediate- or high-risk myelodysplastic syndrome (MDS) ineligible for intensive chemotherapy: final results of the randomized phase III study of the European Organisation for Research and Treatment of Cancer Leukemia Group and the German MDS Study Group
    • Lubbert M., Suciu S., Baila L., Ruter B.H., Platzbecker U., Giagounidis A., et al. Low-dose decitabine versus best supportive care in elderly patients with intermediate- or high-risk myelodysplastic syndrome (MDS) ineligible for intensive chemotherapy: final results of the randomized phase III study of the European Organisation for Research and Treatment of Cancer Leukemia Group and the German MDS Study Group. J Clin Oncol 2011, 29:1987-1996.
    • (2011) J Clin Oncol , vol.29 , pp. 1987-1996
    • Lubbert, M.1    Suciu, S.2    Baila, L.3    Ruter, B.H.4    Platzbecker, U.5    Giagounidis, A.6
  • 14
    • 77957021267 scopus 로고    scopus 로고
    • Effects of azacitidine compared with conventional care regimens in elderly (>/=75years) patients with higher-risk myelodysplastic syndromes
    • Seymour J.F., Fenaux P., Silverman L.R., Mufti G.J., Hellstrom-Lindberg E., Santini V., et al. Effects of azacitidine compared with conventional care regimens in elderly (>/=75years) patients with higher-risk myelodysplastic syndromes. Crit Rev Oncol Hematol 2010, 76:218-227.
    • (2010) Crit Rev Oncol Hematol , vol.76 , pp. 218-227
    • Seymour, J.F.1    Fenaux, P.2    Silverman, L.R.3    Mufti, G.J.4    Hellstrom-Lindberg, E.5    Santini, V.6
  • 15
    • 84864063679 scopus 로고    scopus 로고
    • Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia
    • Kantarjian H.M., Thomas X.G., Dmoszynska A., Wierzbowska A., Mazur G., Mayer J., et al. Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia. J Clin Oncol 2012, 30:2670-2677.
    • (2012) J Clin Oncol , vol.30 , pp. 2670-2677
    • Kantarjian, H.M.1    Thomas, X.G.2    Dmoszynska, A.3    Wierzbowska, A.4    Mazur, G.5    Mayer, J.6
  • 18
    • 62849104641 scopus 로고    scopus 로고
    • Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study
    • Fenaux P., Mufti G.J., Hellstrom-Lindberg E., Santini V., Finelli C., Giagounidis A., et al. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet Oncol 2009, 10:223-232.
    • (2009) Lancet Oncol , vol.10 , pp. 223-232
    • Fenaux, P.1    Mufti, G.J.2    Hellstrom-Lindberg, E.3    Santini, V.4    Finelli, C.5    Giagounidis, A.6
  • 19
    • 77952140672 scopus 로고    scopus 로고
    • Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine
    • Blum W., Garzon R., Klisovic R.B., Schwind S., Walker A., Geyer S., et al. Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine. Proc Natl Acad Sci U S A 2010, 107:7473-7478.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 7473-7478
    • Blum, W.1    Garzon, R.2    Klisovic, R.B.3    Schwind, S.4    Walker, A.5    Geyer, S.6
  • 20
    • 77449149374 scopus 로고    scopus 로고
    • Multicenter, phase II study of decitabine for the first-line treatment of older patients with acute myeloid leukemia
    • Cashen A.F., Schiller G.J., O'Donnell M.R., DiPersio J.F. Multicenter, phase II study of decitabine for the first-line treatment of older patients with acute myeloid leukemia. J Clin Oncol 2010, 28:556-561.
    • (2010) J Clin Oncol , vol.28 , pp. 556-561
    • Cashen, A.F.1    Schiller, G.J.2    O'Donnell, M.R.3    DiPersio, J.F.4
  • 21
    • 84857747740 scopus 로고    scopus 로고
    • A multicenter phase II trial of decitabine as first-line treatment for older patients with acute myeloid leukemia judged unfit for induction chemotherapy
    • Lubbert M., Ruter B.H., Claus R., Schmoor C., Schmid M., Germing U., et al. A multicenter phase II trial of decitabine as first-line treatment for older patients with acute myeloid leukemia judged unfit for induction chemotherapy. Haematologica 2012, 97:393-401.
    • (2012) Haematologica , vol.97 , pp. 393-401
    • Lubbert, M.1    Ruter, B.H.2    Claus, R.3    Schmoor, C.4    Schmid, M.5    Germing, U.6
  • 22
    • 84855416811 scopus 로고    scopus 로고
    • Azacitidine in patients with acute myeloid leukemia medically unfit for or resistant to chemotherapy: a multicenter phase I/II study
    • Al-Ali H.K., Jaekel N., Junghanss C., Maschmeyer G., Krahl R., Cross M., et al. Azacitidine in patients with acute myeloid leukemia medically unfit for or resistant to chemotherapy: a multicenter phase I/II study. Leuk Lymphoma 2012, 53:110-117.
    • (2012) Leuk Lymphoma , vol.53 , pp. 110-117
    • Al-Ali, H.K.1    Jaekel, N.2    Junghanss, C.3    Maschmeyer, G.4    Krahl, R.5    Cross, M.6
  • 23
    • 84870730795 scopus 로고    scopus 로고
    • 5-Azacytidine versus intensive chemotherapy or BSC in elderly (>60years) AML patients: a retrospective analysis [abstract]
    • Serrano J., de la Fuent A., Bergua J., et al. 5-Azacytidine versus intensive chemotherapy or BSC in elderly (>60years) AML patients: a retrospective analysis [abstract]. Blood 2011, 118(21):2612.
    • (2011) Blood , vol.118 , Issue.21 , pp. 2612
    • Serrano, J.1    de la Fuent, A.2    Bergua, J.3
  • 24
  • 25
    • 84876788649 scopus 로고    scopus 로고
    • Azacitidine in patients with WHO-defined AML: results of 155 patients from the Austrian Azacitidine Registry (AAR) of the AGMT study group
    • Pleyer L., Stauder R., Burgstaller S., Schreder M., Tinchon C., Pfeilstocker M., et al. Azacitidine in patients with WHO-defined AML: results of 155 patients from the Austrian Azacitidine Registry (AAR) of the AGMT study group. J Hematol Oncol 2013, 6:32.
    • (2013) J Hematol Oncol , vol.6 , pp. 32
    • Pleyer, L.1    Stauder, R.2    Burgstaller, S.3    Schreder, M.4    Tinchon, C.5    Pfeilstocker, M.6
  • 26
    • 84893712775 scopus 로고    scopus 로고
    • Efficacy of frontline 5-azacytidine in older AML patients unfit for chemotherapy [abstract]
    • Bories P., Bertoli S., Huguet F., Dobbelstein S., Fornecker L., Rauzy O.B., et al. Efficacy of frontline 5-azacytidine in older AML patients unfit for chemotherapy [abstract]. Blood 2011, 118(21):2614.
    • (2011) Blood , vol.118 , Issue.21 , pp. 2614
    • Bories, P.1    Bertoli, S.2    Huguet, F.3    Dobbelstein, S.4    Fornecker, L.5    Rauzy, O.B.6
  • 27
    • 78649486856 scopus 로고    scopus 로고
    • Intensive chemotherapy does not benefit most older patients (age 70years or older) with acute myeloid leukemia
    • Kantarjian H., Ravandi F., O'Brien S., Cortes J., Faderl S., Garcia-Manero G., et al. Intensive chemotherapy does not benefit most older patients (age 70years or older) with acute myeloid leukemia. Blood 2010, 116:4422-4429.
    • (2010) Blood , vol.116 , pp. 4422-4429
    • Kantarjian, H.1    Ravandi, F.2    O'Brien, S.3    Cortes, J.4    Faderl, S.5    Garcia-Manero, G.6
  • 28
    • 79951535539 scopus 로고    scopus 로고
    • Acute myeloid leukaemia in the elderly: a review
    • Pollyea D.A., Kohrt H.E., Medeiros B.C. Acute myeloid leukaemia in the elderly: a review. Br J Haematol 2011, 152:524-542.
    • (2011) Br J Haematol , vol.152 , pp. 524-542
    • Pollyea, D.A.1    Kohrt, H.E.2    Medeiros, B.C.3
  • 29
    • 23944440464 scopus 로고    scopus 로고
    • Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT
    • Sorror M.L., Maris M.B., Storb R., Baron F., Sandmaier B.M., Maloney D.G., et al. Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT. Blood 2005, 106:2912-2919.
    • (2005) Blood , vol.106 , pp. 2912-2919
    • Sorror, M.L.1    Maris, M.B.2    Storb, R.3    Baron, F.4    Sandmaier, B.M.5    Maloney, D.G.6
  • 31
    • 84877941725 scopus 로고    scopus 로고
    • Azacitidine as front-line therapy in AML: results from the Spanish National Registry. Alma Study Investigators [abstract]
    • Ramos F., Martinez-Robles V., Bargay J., Deben G., Garrido A., Serrano J., et al. Azacitidine as front-line therapy in AML: results from the Spanish National Registry. Alma Study Investigators [abstract]. Blood 2012, 120(21):3593.
    • (2012) Blood , vol.120 , Issue.21 , pp. 3593
    • Ramos, F.1    Martinez-Robles, V.2    Bargay, J.3    Deben, G.4    Garrido, A.5    Serrano, J.6
  • 32
    • 34547201150 scopus 로고    scopus 로고
    • Intensive chemotherapy is not recommended for patients aged >60years who have myelodysplastic syndromes or acute myeloid leukemia with high-risk karyotypes
    • Knipp S., Hildebrand B., Kundgen A., Giagounidis A., Kobbe G., Haas R., et al. Intensive chemotherapy is not recommended for patients aged >60years who have myelodysplastic syndromes or acute myeloid leukemia with high-risk karyotypes. Cancer 2007, 110:345-352.
    • (2007) Cancer , vol.110 , pp. 345-352
    • Knipp, S.1    Hildebrand, B.2    Kundgen, A.3    Giagounidis, A.4    Kobbe, G.5    Haas, R.6
  • 33
    • 33745191374 scopus 로고    scopus 로고
    • Pretreatment cytogenetics add to other prognostic factors predicting complete remission and long-term outcome in patients 60years of age or older with acute myeloid leukemia: results from Cancer and Leukemia Group B 8461
    • Farag S.S., Archer K.J., Mrozek K., Ruppert A.S., Carroll A.J., Vardiman J.W., et al. Pretreatment cytogenetics add to other prognostic factors predicting complete remission and long-term outcome in patients 60years of age or older with acute myeloid leukemia: results from Cancer and Leukemia Group B 8461. Blood 2006, 108:63-73.
    • (2006) Blood , vol.108 , pp. 63-73
    • Farag, S.S.1    Archer, K.J.2    Mrozek, K.3    Ruppert, A.S.4    Carroll, A.J.5    Vardiman, J.W.6
  • 34
    • 33751172127 scopus 로고    scopus 로고
    • Cytogenetics and age are major determinants of outcome in intensively treated acute myeloid leukemia patients older than 60years: results from AMLSG trial AML HD98-B
    • Frohling S., Schlenk R.F., Kayser S., Morhardt M., Benner A., Dohner K., et al. Cytogenetics and age are major determinants of outcome in intensively treated acute myeloid leukemia patients older than 60years: results from AMLSG trial AML HD98-B. Blood 2006, 108:3280-3288.
    • (2006) Blood , vol.108 , pp. 3280-3288
    • Frohling, S.1    Schlenk, R.F.2    Kayser, S.3    Morhardt, M.4    Benner, A.5    Dohner, K.6
  • 35
    • 0035469883 scopus 로고    scopus 로고
    • The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial
    • Grimwade D., Walker H., Harrison G., Oliver F., Chatters S., Harrison C.J., et al. The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial. Blood 2001, 98:1312-1320.
    • (2001) Blood , vol.98 , pp. 1312-1320
    • Grimwade, D.1    Walker, H.2    Harrison, G.3    Oliver, F.4    Chatters, S.5    Harrison, C.J.6
  • 36
    • 84856802139 scopus 로고    scopus 로고
    • Azacitidine for the treatment of patients with acute myeloid leukemia: report of 82 patients enrolled in an Italian Compassionate Program
    • Maurillo L., Venditti A., Spagnoli A., Gaidano G., Ferrero D., Oliva E., et al. Azacitidine for the treatment of patients with acute myeloid leukemia: report of 82 patients enrolled in an Italian Compassionate Program. Cancer 2012, 118:1014-1022.
    • (2012) Cancer , vol.118 , pp. 1014-1022
    • Maurillo, L.1    Venditti, A.2    Spagnoli, A.3    Gaidano, G.4    Ferrero, D.5    Oliva, E.6
  • 37
    • 85047688311 scopus 로고    scopus 로고
    • Prognostic impact of acute myeloid leukemia classification. Importance of detection of recurring cytogenetic abnormalities and multilineage dysplasia on survival
    • Arber D.A., Stein A.S., Carter N.H., Ikle D., Forman S.J., Slovak M.L. Prognostic impact of acute myeloid leukemia classification. Importance of detection of recurring cytogenetic abnormalities and multilineage dysplasia on survival. Am J Clin Pathol 2003, 119:672-680.
    • (2003) Am J Clin Pathol , vol.119 , pp. 672-680
    • Arber, D.A.1    Stein, A.S.2    Carter, N.H.3    Ikle, D.4    Forman, S.J.5    Slovak, M.L.6
  • 38
    • 0029737359 scopus 로고    scopus 로고
    • Acute myeloid leukemia-type chemotherapy for newly diagnosed patients without antecedent cytopenias having myelodysplastic syndrome as defined by French-American-British criteria: a Cancer and Leukemia Group B Study
    • Bernstein S.H., Brunetto V.L., Davey F.R., Wurster-Hill D., Mayer R.J., Stone R.M., et al. Acute myeloid leukemia-type chemotherapy for newly diagnosed patients without antecedent cytopenias having myelodysplastic syndrome as defined by French-American-British criteria: a Cancer and Leukemia Group B Study. J Clin Oncol 1996, 14:2486-2494.
    • (1996) J Clin Oncol , vol.14 , pp. 2486-2494
    • Bernstein, S.H.1    Brunetto, V.L.2    Davey, F.R.3    Wurster-Hill, D.4    Mayer, R.J.5    Stone, R.M.6
  • 39
    • 0030765385 scopus 로고    scopus 로고
    • Effect of diagnosis (refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, or acute myeloid leukemia [AML]) on outcome of AML-type chemotherapy
    • Estey E., Thall P., Beran M., Kantarjian H., Pierce S., Keating M. Effect of diagnosis (refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, or acute myeloid leukemia [AML]) on outcome of AML-type chemotherapy. Blood 1997, 90:2969-2977.
    • (1997) Blood , vol.90 , pp. 2969-2977
    • Estey, E.1    Thall, P.2    Beran, M.3    Kantarjian, H.4    Pierce, S.5    Keating, M.6
  • 40
    • 84875961796 scopus 로고    scopus 로고
    • Poor outcome in secondary acute myeloid leukemia (AML): a first report from the population-based Swedish Acute Leukemia Registry [abstract]
    • Lehmann S., Lazarevic V., Horstedt A.S., Hulegardh E., Nilsson C., Antunovic P., et al. Poor outcome in secondary acute myeloid leukemia (AML): a first report from the population-based Swedish Acute Leukemia Registry [abstract]. Blood 2012, 120(21):130.
    • (2012) Blood , vol.120 , Issue.21 , pp. 130
    • Lehmann, S.1    Lazarevic, V.2    Horstedt, A.S.3    Hulegardh, E.4    Nilsson, C.5    Antunovic, P.6
  • 41
    • 78149453788 scopus 로고    scopus 로고
    • Treatment of progression of Philadelphia-negative myeloproliferative neoplasms to myelodysplastic syndrome or acute myeloid leukemia by azacitidine: a report on 54 cases on the behalf of the Groupe Francophone des Myelodysplasies (GFM)
    • Thepot S., Itzykson R., Seegers V., Raffoux E., Quesnel B., Chait Y., et al. Treatment of progression of Philadelphia-negative myeloproliferative neoplasms to myelodysplastic syndrome or acute myeloid leukemia by azacitidine: a report on 54 cases on the behalf of the Groupe Francophone des Myelodysplasies (GFM). Blood 2010, 116:3735-3742.
    • (2010) Blood , vol.116 , pp. 3735-3742
    • Thepot, S.1    Itzykson, R.2    Seegers, V.3    Raffoux, E.4    Quesnel, B.5    Chait, Y.6
  • 42
    • 0037217950 scopus 로고    scopus 로고
    • Early blast clearance by remission induction therapy is a major independent prognostic factor for both achievement of complete remission and long-term outcome in acute myeloid leukemia: data from the German AML Cooperative Group (AMLCG) 1992 Trial
    • Kern W., Haferlach T., Schoch C., Loffler H., Gassmann W., Heinecke A., et al. Early blast clearance by remission induction therapy is a major independent prognostic factor for both achievement of complete remission and long-term outcome in acute myeloid leukemia: data from the German AML Cooperative Group (AMLCG) 1992 Trial. Blood 2003, 101:64-70.
    • (2003) Blood , vol.101 , pp. 64-70
    • Kern, W.1    Haferlach, T.2    Schoch, C.3    Loffler, H.4    Gassmann, W.5    Heinecke, A.6
  • 43
    • 0008381951 scopus 로고    scopus 로고
    • A simple, robust, validated and highly predictive index for the determination of risk-directed therapy in acute myeloid leukaemia derived from the MRC AML 10 trial. United Kingdom Medical Research Council's Adult and Childhood Leukaemia Working Parties
    • Wheatley K., Burnett A.K., Goldstone A.H., Gray R.G., Hann I.M., Harrison C.J., et al. A simple, robust, validated and highly predictive index for the determination of risk-directed therapy in acute myeloid leukaemia derived from the MRC AML 10 trial. United Kingdom Medical Research Council's Adult and Childhood Leukaemia Working Parties. Br J Haematol 1999, 107:69-79.
    • (1999) Br J Haematol , vol.107 , pp. 69-79
    • Wheatley, K.1    Burnett, A.K.2    Goldstone, A.H.3    Gray, R.G.4    Hann, I.M.5    Harrison, C.J.6
  • 44
    • 0035469856 scopus 로고    scopus 로고
    • Attempts to improve treatment outcomes in acute myeloid leukemia (AML) in older patients: the results of the United Kingdom Medical Research Council AML11 trial
    • Goldstone A.H., Burnett A.K., Wheatley K., Smith A.G., Hutchinson R.M., Clark R.E. Attempts to improve treatment outcomes in acute myeloid leukemia (AML) in older patients: the results of the United Kingdom Medical Research Council AML11 trial. Blood 2001, 98:1302-1311.
    • (2001) Blood , vol.98 , pp. 1302-1311
    • Goldstone, A.H.1    Burnett, A.K.2    Wheatley, K.3    Smith, A.G.4    Hutchinson, R.M.5    Clark, R.E.6
  • 45
    • 0035437132 scopus 로고    scopus 로고
    • Postremission therapy in older patients with de novo acute myeloid leukemia: a randomized trial comparing mitoxantrone and intermediate-dose cytarabine with standard-dose cytarabine
    • Stone R.M., Berg D.T., George S.L., Dodge R.K., Paciucci P.A., Schulman P.P., et al. Postremission therapy in older patients with de novo acute myeloid leukemia: a randomized trial comparing mitoxantrone and intermediate-dose cytarabine with standard-dose cytarabine. Blood 2001, 98:548-553.
    • (2001) Blood , vol.98 , pp. 548-553
    • Stone, R.M.1    Berg, D.T.2    George, S.L.3    Dodge, R.K.4    Paciucci, P.A.5    Schulman, P.P.6
  • 46
    • 77954581656 scopus 로고    scopus 로고
    • Maintenance treatment with azacitidine for patients with high-risk myelodysplastic syndromes (MDS) or acute myeloid leukaemia following MDS in complete remission after induction chemotherapy
    • Grovdal M., Karimi M., Khan R., Aggerholm A., Antunovic P., Astermark J., et al. Maintenance treatment with azacitidine for patients with high-risk myelodysplastic syndromes (MDS) or acute myeloid leukaemia following MDS in complete remission after induction chemotherapy. Br J Haematol 2010, 150:293-302.
    • (2010) Br J Haematol , vol.150 , pp. 293-302
    • Grovdal, M.1    Karimi, M.2    Khan, R.3    Aggerholm, A.4    Antunovic, P.5    Astermark, J.6
  • 47
    • 79952667434 scopus 로고    scopus 로고
    • Continued azacitidine therapy beyond time of first response improves quality of response in patients with higher-risk myelodysplastic syndromes
    • Silverman L.R., Fenaux P., Mufti G.J., Santini V., Hellstrom-Lindberg E., Gattermann N., et al. Continued azacitidine therapy beyond time of first response improves quality of response in patients with higher-risk myelodysplastic syndromes. Cancer 2011, 117:2697-2702.
    • (2011) Cancer , vol.117 , pp. 2697-2702
    • Silverman, L.R.1    Fenaux, P.2    Mufti, G.J.3    Santini, V.4    Hellstrom-Lindberg, E.5    Gattermann, N.6
  • 48
    • 84875261536 scopus 로고    scopus 로고
    • Rapid loss of response after withdrawal of treatment with azacitidine: a case series in patients with higher-risk myelodysplastic syndromes or chronic myelomonocytic leukemia
    • Voso M.T., Breccia M., Lunghi M., Poloni A., Niscola P., Finelli C., et al. Rapid loss of response after withdrawal of treatment with azacitidine: a case series in patients with higher-risk myelodysplastic syndromes or chronic myelomonocytic leukemia. Eur J Haematol 2013, 90:345-348.
    • (2013) Eur J Haematol , vol.90 , pp. 345-348
    • Voso, M.T.1    Breccia, M.2    Lunghi, M.3    Poloni, A.4    Niscola, P.5    Finelli, C.6
  • 49
    • 33751267902 scopus 로고    scopus 로고
    • Acute myeloid leukaemia
    • Estey E., Dohner H. Acute myeloid leukaemia. Lancet 2006, 368:1894-1907.
    • (2006) Lancet , vol.368 , pp. 1894-1907
    • Estey, E.1    Dohner, H.2
  • 51
    • 84870427766 scopus 로고    scopus 로고
    • Transfusion independence and survival in patients with acute myeloid leukemia treated with 5-azacytidine
    • Gavillet M., Noetzli J., Blum S., Duchosal M.A., Spertini O., Lambert J.F. Transfusion independence and survival in patients with acute myeloid leukemia treated with 5-azacytidine. Haematologica 2012, 97:1929-1931.
    • (2012) Haematologica , vol.97 , pp. 1929-1931
    • Gavillet, M.1    Noetzli, J.2    Blum, S.3    Duchosal, M.A.4    Spertini, O.5    Lambert, J.F.6
  • 52
    • 84870575093 scopus 로고    scopus 로고
    • Decitabine for the treatment of acute myeloid leukemia (AML): Memorial Sloan-Kettering Cancer Center experience [abstract]
    • Ganetsky A., Adel N.G., Frattini M.G., Maslak P.G., Heaney M.L., Jurcic J.G., et al. Decitabine for the treatment of acute myeloid leukemia (AML): Memorial Sloan-Kettering Cancer Center experience [abstract]. J Clin Oncol 2011, 29(Suppl. 15):6593.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL. 15 , pp. 6593
    • Ganetsky, A.1    Adel, N.G.2    Frattini, M.G.3    Maslak, P.G.4    Heaney, M.L.5    Jurcic, J.G.6
  • 53
    • 84893674001 scopus 로고    scopus 로고
    • A Retrospective Study of Decitabine for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia: Lack of Response Observed In a Heavily Pretreated Population [abstract]
    • George T.J., Woolery J.E., Wetzstein G.A., Ho V.Q., Lancet J.E., List A.F., et al. A Retrospective Study of Decitabine for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia: Lack of Response Observed In a Heavily Pretreated Population [abstract]. Blood 2010, 116(21):2186.
    • (2010) Blood , vol.116 , Issue.21 , pp. 2186
    • George, T.J.1    Woolery, J.E.2    Wetzstein, G.A.3    Ho, V.Q.4    Lancet, J.E.5    List, A.F.6
  • 54
    • 60249094793 scopus 로고    scopus 로고
    • Mechanisms of resistance to 5-aza-2'-deoxycytidine in human cancer cell lines
    • Qin T., Jelinek J., Si J., Shu J., Issa J.P. Mechanisms of resistance to 5-aza-2'-deoxycytidine in human cancer cell lines. Blood 2009, 113:659-667.
    • (2009) Blood , vol.113 , pp. 659-667
    • Qin, T.1    Jelinek, J.2    Si, J.3    Shu, J.4    Issa, J.P.5
  • 55
    • 84855410095 scopus 로고    scopus 로고
    • Monitoring and prevention of relapse after allogeneic hematopoietic cell transplantation for myeloid malignancies
    • Bacher U., Talano J.A., Bishop M.R. Monitoring and prevention of relapse after allogeneic hematopoietic cell transplantation for myeloid malignancies. Biol Blood Marrow Transplant 2012, 18:S62-S73.
    • (2012) Biol Blood Marrow Transplant , vol.18
    • Bacher, U.1    Talano, J.A.2    Bishop, M.R.3
  • 56
    • 28644452432 scopus 로고    scopus 로고
    • Comparative outcome of reduced intensity and myeloablative conditioning regimen in HLA identical sibling allogeneic haematopoietic stem cell transplantation for patients older than 50years of age with acute myeloblastic leukaemia: a retrospective survey from the Acute Leukemia Working Party (ALWP) of the European group for Blood and Marrow Transplantation (EBMT)
    • Aoudjhane M., Labopin M., Gorin N.C., Shimoni A., Ruutu T., Kolb H.J., et al. Comparative outcome of reduced intensity and myeloablative conditioning regimen in HLA identical sibling allogeneic haematopoietic stem cell transplantation for patients older than 50years of age with acute myeloblastic leukaemia: a retrospective survey from the Acute Leukemia Working Party (ALWP) of the European group for Blood and Marrow Transplantation (EBMT). Leukemia 2005, 19:2304-2312.
    • (2005) Leukemia , vol.19 , pp. 2304-2312
    • Aoudjhane, M.1    Labopin, M.2    Gorin, N.C.3    Shimoni, A.4    Ruutu, T.5    Kolb, H.J.6
  • 57
    • 33646196925 scopus 로고    scopus 로고
    • Allogeneic transplantation for the elderly patient with acute myelogenous leukemia or myelodysplastic syndrome
    • de Lima M., Giralt S. Allogeneic transplantation for the elderly patient with acute myelogenous leukemia or myelodysplastic syndrome. Semin Hematol 2006, 43:107-117.
    • (2006) Semin Hematol , vol.43 , pp. 107-117
    • de Lima, M.1    Giralt, S.2
  • 58
    • 33846924515 scopus 로고    scopus 로고
    • Prospective feasibility analysis of reduced-intensity conditioning (RIC) regimens for hematopoietic stem cell transplantation (HSCT) in elderly patients with acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS)
    • Estey E., de Lima M., Tibes R., Pierce S., Kantarjian H., Champlin R., et al. Prospective feasibility analysis of reduced-intensity conditioning (RIC) regimens for hematopoietic stem cell transplantation (HSCT) in elderly patients with acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS). Blood 2007, 109:1395-1400.
    • (2007) Blood , vol.109 , pp. 1395-1400
    • Estey, E.1    de Lima, M.2    Tibes, R.3    Pierce, S.4    Kantarjian, H.5    Champlin, R.6
  • 59
    • 33644833398 scopus 로고    scopus 로고
    • Treatment for acute myelogenous leukemia by low-dose, total-body, irradiation-based conditioning and hematopoietic cell transplantation from related and unrelated donors
    • Hegenbart U., Niederwieser D., Sandmaier B.M., Maris M.B., Shizuru J.A., Greinix H., et al. Treatment for acute myelogenous leukemia by low-dose, total-body, irradiation-based conditioning and hematopoietic cell transplantation from related and unrelated donors. J Clin Oncol 2006, 24:444-453.
    • (2006) J Clin Oncol , vol.24 , pp. 444-453
    • Hegenbart, U.1    Niederwieser, D.2    Sandmaier, B.M.3    Maris, M.B.4    Shizuru, J.A.5    Greinix, H.6
  • 60
    • 55949099856 scopus 로고    scopus 로고
    • Matched unrelated or matched sibling donors result in comparable survival after allogeneic stem-cell transplantation in elderly patients with acute myeloid leukemia: a report from the cooperative German Transplant Study Group
    • Schetelig J., Bornhauser M., Schmid C., Hertenstein B., Schwerdtfeger R., Martin H., et al. Matched unrelated or matched sibling donors result in comparable survival after allogeneic stem-cell transplantation in elderly patients with acute myeloid leukemia: a report from the cooperative German Transplant Study Group. J Clin Oncol 2008, 26:5183-5191.
    • (2008) J Clin Oncol , vol.26 , pp. 5183-5191
    • Schetelig, J.1    Bornhauser, M.2    Schmid, C.3    Hertenstein, B.4    Schwerdtfeger, R.5    Martin, H.6
  • 61
    • 0141958295 scopus 로고    scopus 로고
    • Reduced-intensity conditioning for unrelated donor hematopoietic stem cell transplantation as treatment for myeloid malignancies in patients older than 55years
    • Wong R., Giralt S.A., Martin T., Couriel D.R., Anagnostopoulos A., Hosing C., et al. Reduced-intensity conditioning for unrelated donor hematopoietic stem cell transplantation as treatment for myeloid malignancies in patients older than 55years. Blood 2003, 102:3052-3059.
    • (2003) Blood , vol.102 , pp. 3052-3059
    • Wong, R.1    Giralt, S.A.2    Martin, T.3    Couriel, D.R.4    Anagnostopoulos, A.5    Hosing, C.6
  • 62
    • 84888322475 scopus 로고    scopus 로고
    • Azacitidine is well tolerated after allogeneic stem cell transplantation and its administration is associated with a reduced risk of acute graft-versus-host disease [abstract]
    • Craddock C., Jilani N., Siddique S., Vyas P., Goodyear O., Dennis M., et al. Azacitidine is well tolerated after allogeneic stem cell transplantation and its administration is associated with a reduced risk of acute graft-versus-host disease [abstract]. Haematologica 2012, 97(1):21.
    • (2012) Haematologica , vol.97 , Issue.1 , pp. 21
    • Craddock, C.1    Jilani, N.2    Siddique, S.3    Vyas, P.4    Goodyear, O.5    Dennis, M.6
  • 63
    • 78649601394 scopus 로고    scopus 로고
    • Maintenance therapy with low-dose azacitidine after allogeneic hematopoietic stem cell transplantation for recurrent acute myelogenous leukemia or myelodysplastic syndrome: a dose and schedule finding study
    • De Lima M., Giralt S., Thall P.F., de Padua S.L., Jones R.B., Komanduri K., et al. Maintenance therapy with low-dose azacitidine after allogeneic hematopoietic stem cell transplantation for recurrent acute myelogenous leukemia or myelodysplastic syndrome: a dose and schedule finding study. Cancer 2010, 116:5420-5431.
    • (2010) Cancer , vol.116 , pp. 5420-5431
    • De Lima, M.1    Giralt, S.2    Thall, P.F.3    de Padua, S.L.4    Jones, R.B.5    Komanduri, K.6
  • 64
    • 65649120045 scopus 로고    scopus 로고
    • Low-dose azacitidine after allogeneic stem cell transplantation for acute leukemia
    • Jabbour E., Giralt S., Kantarjian H., Garcia-Manero G., Jagasia M., Kebriaei P., et al. Low-dose azacitidine after allogeneic stem cell transplantation for acute leukemia. Cancer 2009, 115:1899-1905.
    • (2009) Cancer , vol.115 , pp. 1899-1905
    • Jabbour, E.1    Giralt, S.2    Kantarjian, H.3    Garcia-Manero, G.4    Jagasia, M.5    Kebriaei, P.6
  • 65
    • 84857999119 scopus 로고    scopus 로고
    • Azacitidine for treatment of imminent relapse in MDS or AML patients after allogeneic HSCT: results of the RELAZA trial
    • Platzbecker U., Wermke M., Radke J., Oelschlaegel U., Seltmann F., Kiani A., et al. Azacitidine for treatment of imminent relapse in MDS or AML patients after allogeneic HSCT: results of the RELAZA trial. Leukemia 2012, 26:381-389.
    • (2012) Leukemia , vol.26 , pp. 381-389
    • Platzbecker, U.1    Wermke, M.2    Radke, J.3    Oelschlaegel, U.4    Seltmann, F.5    Kiani, A.6
  • 67
    • 77952419308 scopus 로고    scopus 로고
    • 5-Azacytidine for the treatment of patients with acute myeloid leukemia or myelodysplastic syndrome who relapse after allo-SCT: a retrospective analysis
    • Czibere A., Bruns I., Kroger N., Platzbecker U., Lind J., Zohren F., et al. 5-Azacytidine for the treatment of patients with acute myeloid leukemia or myelodysplastic syndrome who relapse after allo-SCT: a retrospective analysis. Bone Marrow Transplant 2010, 45:872-876.
    • (2010) Bone Marrow Transplant , vol.45 , pp. 872-876
    • Czibere, A.1    Bruns, I.2    Kroger, N.3    Platzbecker, U.4    Lind, J.5    Zohren, F.6
  • 68
    • 33845216261 scopus 로고    scopus 로고
    • Successful treatment of relapsed AML after allogeneic stem cell transplantation with azacitidine
    • Graef T., Kuendgen A., Fenk R., Zohren F., Haas R., Kobbe G. Successful treatment of relapsed AML after allogeneic stem cell transplantation with azacitidine. Leuk Res 2007, 31:257-259.
    • (2007) Leuk Res , vol.31 , pp. 257-259
    • Graef, T.1    Kuendgen, A.2    Fenk, R.3    Zohren, F.4    Haas, R.5    Kobbe, G.6
  • 69
    • 77950614210 scopus 로고    scopus 로고
    • Efficacy of a 3-day, low-dose treatment with 5-azacytidine followed by donor lymphocyte infusions in older patients with acute myeloid leukemia or chronic myelomonocytic leukemia relapsed after allografting
    • Lubbert M., Bertz H., Wasch R., Marks R., Ruter B., Claus R., et al. Efficacy of a 3-day, low-dose treatment with 5-azacytidine followed by donor lymphocyte infusions in older patients with acute myeloid leukemia or chronic myelomonocytic leukemia relapsed after allografting. Bone Marrow Transplant 2010, 45:627-632.
    • (2010) Bone Marrow Transplant , vol.45 , pp. 627-632
    • Lubbert, M.1    Bertz, H.2    Wasch, R.3    Marks, R.4    Ruter, B.5    Claus, R.6
  • 70
    • 84867616893 scopus 로고    scopus 로고
    • Phase II study of azacitidine and donor lymphocyte infusions as first salvage therapy in patients with acute myeloid leukemia or myelodysplastic syndromes relapsing after allogeneic HSCT: final results of the AZARELA study [abstract]
    • Schroeder T., Czibere A., Kroger N., Platzbecker U., Bug G., Uharek L., et al. Phase II study of azacitidine and donor lymphocyte infusions as first salvage therapy in patients with acute myeloid leukemia or myelodysplastic syndromes relapsing after allogeneic HSCT: final results of the AZARELA study [abstract]. Blood 2011, 118(21):656.
    • (2011) Blood , vol.118 , Issue.21 , pp. 656
    • Schroeder, T.1    Czibere, A.2    Kroger, N.3    Platzbecker, U.4    Bug, G.5    Uharek, L.6
  • 71
    • 84859582203 scopus 로고    scopus 로고
    • Azacitidine augments expansion of regulatory T cells after allogeneic stem cell transplantation in patients with acute myeloid leukemia (AML)
    • Goodyear O.C., Dennis M., Jilani N.Y., Loke J., Siddique S., Ryan G., et al. Azacitidine augments expansion of regulatory T cells after allogeneic stem cell transplantation in patients with acute myeloid leukemia (AML). Blood 2012, 119:3361-3369.
    • (2012) Blood , vol.119 , pp. 3361-3369
    • Goodyear, O.C.1    Dennis, M.2    Jilani, N.Y.3    Loke, J.4    Siddique, S.5    Ryan, G.6
  • 72
    • 77954753267 scopus 로고    scopus 로고
    • Management and supportive care measures for adverse events in patients with myelodysplastic syndromes treated with azacitidine*
    • Santini V., Fenaux P., Mufti G.J., Hellstrom-Lindberg E., Silverman L.R., List A., et al. Management and supportive care measures for adverse events in patients with myelodysplastic syndromes treated with azacitidine*. Eur J Haematol 2010, 85:130-138.
    • (2010) Eur J Haematol , vol.85 , pp. 130-138
    • Santini, V.1    Fenaux, P.2    Mufti, G.J.3    Hellstrom-Lindberg, E.4    Silverman, L.R.5    List, A.6
  • 73
    • 0037092962 scopus 로고    scopus 로고
    • Impact of azacytidine on the quality of life of patients with myelodysplastic syndrome treated in a randomized phase III trial: a Cancer and Leukemia Group B study
    • Kornblith A.B., Herndon J.E., Silverman L.R., Demakos E.P., Odchimar-Reissig R., Holland J.F., et al. Impact of azacytidine on the quality of life of patients with myelodysplastic syndrome treated in a randomized phase III trial: a Cancer and Leukemia Group B study. J Clin Oncol 2002, 20:2441-2452.
    • (2002) J Clin Oncol , vol.20 , pp. 2441-2452
    • Kornblith, A.B.1    Herndon, J.E.2    Silverman, L.R.3    Demakos, E.P.4    Odchimar-Reissig, R.5    Holland, J.F.6
  • 74
    • 77749302093 scopus 로고    scopus 로고
    • A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines
    • Hollenbach P.W., Nguyen A.N., Brady H., Williams M., Ning Y., Richard N., et al. A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines. PLoS One 2010, 5:e9001.
    • (2010) PLoS One , vol.5
    • Hollenbach, P.W.1    Nguyen, A.N.2    Brady, H.3    Williams, M.4    Ning, Y.5    Richard, N.6
  • 75
    • 70350506791 scopus 로고    scopus 로고
    • Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies
    • Fandy T.E., Herman J.G., Kerns P., Jiemjit A., Sugar E.A., Choi S.H., et al. Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies. Blood 2009, 114:2764-2773.
    • (2009) Blood , vol.114 , pp. 2764-2773
    • Fandy, T.E.1    Herman, J.G.2    Kerns, P.3    Jiemjit, A.4    Sugar, E.A.5    Choi, S.H.6
  • 76
    • 34548131144 scopus 로고    scopus 로고
    • CDKN2B methylation status and isolated chromosome 7 abnormalities predict responses to treatment with 5-azacytidine
    • Raj K., John A., Ho A., Chronis C., Khan S., Samuel J., et al. CDKN2B methylation status and isolated chromosome 7 abnormalities predict responses to treatment with 5-azacytidine. Leukemia 2007, 21:1937-1944.
    • (2007) Leukemia , vol.21 , pp. 1937-1944
    • Raj, K.1    John, A.2    Ho, A.3    Chronis, C.4    Khan, S.5    Samuel, J.6
  • 77
    • 84879327525 scopus 로고    scopus 로고
    • Pretreatment Long interspersed element (LINE)-1 methylation levels, not early hypomethylation under treatment, predict hematological response to azacitidine in elderly patients with acute myeloid leukemia
    • Cross M., Bach E., Tran T., Krahl R., Jaekel N., Niederwieser D., et al. Pretreatment Long interspersed element (LINE)-1 methylation levels, not early hypomethylation under treatment, predict hematological response to azacitidine in elderly patients with acute myeloid leukemia. Onco Targets Ther 2013, 6:741-748. 10.2147/OTT.S45459.
    • (2013) Onco Targets Ther , vol.6 , pp. 741-748
    • Cross, M.1    Bach, E.2    Tran, T.3    Krahl, R.4    Jaekel, N.5    Niederwieser, D.6
  • 78
    • 84887890681 scopus 로고    scopus 로고
    • Safety and Efficacy of Oral Azacitidine (CC-486) Administered in Extended Treatment Schedules to Patients with Lower-Risk Myelodysplastic Syndromes
    • Garcia-Manero G., Gore S.D., Kambhampati S., Scott B.L., Tefferi A., Cogle C.R., et al. Safety and Efficacy of Oral Azacitidine (CC-486) Administered in Extended Treatment Schedules to Patients with Lower-Risk Myelodysplastic Syndromes. Blood 2012, 120:424.
    • (2012) Blood , vol.120 , pp. 424
    • Garcia-Manero, G.1    Gore, S.D.2    Kambhampati, S.3    Scott, B.L.4    Tefferi, A.5    Cogle, C.R.6
  • 79
    • 33744918070 scopus 로고    scopus 로고
    • DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia
    • Yang A.S., Doshi K.D., Choi S.W., Mason J.B., Mannari R.K., Gharybian V., et al. DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia. Cancer Res 2006, 66:5495-5503.
    • (2006) Cancer Res , vol.66 , pp. 5495-5503
    • Yang, A.S.1    Doshi, K.D.2    Choi, S.W.3    Mason, J.B.4    Mannari, R.K.5    Gharybian, V.6
  • 80
    • 84866551964 scopus 로고    scopus 로고
    • Genome-wide methylation profiling in decitabine-treated patients with acute myeloid leukemia
    • Yan P., Frankhouser D., Murphy M., Tam H.H., Rodriguez B., Curfman J., et al. Genome-wide methylation profiling in decitabine-treated patients with acute myeloid leukemia. Blood 2012, 120:2466-2474.
    • (2012) Blood , vol.120 , pp. 2466-2474
    • Yan, P.1    Frankhouser, D.2    Murphy, M.3    Tam, H.H.4    Rodriguez, B.5    Curfman, J.6
  • 81
    • 0014872738 scopus 로고
    • Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia
    • Li L.H., Olin E.J., Buskirk H.H., Reineke L.M. Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia. Cancer Res 1970, 30:2760-2769.
    • (1970) Cancer Res , vol.30 , pp. 2760-2769
    • Li, L.H.1    Olin, E.J.2    Buskirk, H.H.3    Reineke, L.M.4
  • 82
    • 0016295874 scopus 로고
    • Characterization of polyribosomes and maturation of ribosomal RNA in hepatoma cells treated with 5-azacytidine
    • Cihak A., Weiss J.W., Pitot H.C. Characterization of polyribosomes and maturation of ribosomal RNA in hepatoma cells treated with 5-azacytidine. Cancer Res 1974, 34:3003-3009.
    • (1974) Cancer Res , vol.34 , pp. 3003-3009
    • Cihak, A.1    Weiss, J.W.2    Pitot, H.C.3
  • 83
    • 0018855455 scopus 로고
    • Mechanism of 5-azacytidine-induced transfer RNA cytosine-5-methyltransferase deficiency
    • Lu L.J., Randerath K. Mechanism of 5-azacytidine-induced transfer RNA cytosine-5-methyltransferase deficiency. Cancer Res 1980, 40:2701-2705.
    • (1980) Cancer Res , vol.40 , pp. 2701-2705
    • Lu, L.J.1    Randerath, K.2
  • 84
    • 0015909804 scopus 로고
    • The mechanism of inhibition of protein synthesis by 5-azacytidine in HeLa cells
    • Reichman M., Penman S. The mechanism of inhibition of protein synthesis by 5-azacytidine in HeLa cells. Biochim Biophys Acta 1973, 324:282-289.
    • (1973) Biochim Biophys Acta , vol.324 , pp. 282-289
    • Reichman, M.1    Penman, S.2
  • 85
    • 77958598354 scopus 로고    scopus 로고
    • Equitoxic doses of 5-azacytidine and 5-aza-2'deoxycytidine induce diverse immediate and overlapping heritable changes in the transcriptome
    • Qiu X., Hother C., Ralfkiaer U.M., Sogaard A., Lu Q., Workman C.T., et al. Equitoxic doses of 5-azacytidine and 5-aza-2'deoxycytidine induce diverse immediate and overlapping heritable changes in the transcriptome. PLoS One 2010, 5:e12994.
    • (2010) PLoS One , vol.5
    • Qiu, X.1    Hother, C.2    Ralfkiaer, U.M.3    Sogaard, A.4    Lu, Q.5    Workman, C.T.6
  • 86
    • 70350234722 scopus 로고    scopus 로고
    • Azacytidine inhibits RNA methylation at DNMT2 target sites in human cancer cell lines
    • Schaefer M., Hagemann S., Hanna K., Lyko F. Azacytidine inhibits RNA methylation at DNMT2 target sites in human cancer cell lines. Cancer Res 2009, 69:8127-8132.
    • (2009) Cancer Res , vol.69 , pp. 8127-8132
    • Schaefer, M.1    Hagemann, S.2    Hanna, K.3    Lyko, F.4
  • 87
    • 0027261147 scopus 로고
    • The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents
    • Gorczyca W., Gong J., Ardelt B., Traganos F., Darzynkiewicz Z. The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents. Cancer Res 1993, 53:3186-3192.
    • (1993) Cancer Res , vol.53 , pp. 3186-3192
    • Gorczyca, W.1    Gong, J.2    Ardelt, B.3    Traganos, F.4    Darzynkiewicz, Z.5
  • 88
    • 0029013514 scopus 로고
    • Induction of apoptosis by 5-azacytidine: drug concentration-dependent differences in cell cycle specificity
    • Murakami T., Li X., Gong J., Bhatia U., Traganos F., Darzynkiewicz Z. Induction of apoptosis by 5-azacytidine: drug concentration-dependent differences in cell cycle specificity. Cancer Res 1995, 55:3093-3098.
    • (1995) Cancer Res , vol.55 , pp. 3093-3098
    • Murakami, T.1    Li, X.2    Gong, J.3    Bhatia, U.4    Traganos, F.5    Darzynkiewicz, Z.6
  • 89
    • 77951045228 scopus 로고    scopus 로고
    • Signatures of polycomb repression and reduced H3K4 trimethylation are associated with p15INK4b DNA methylation in AML
    • Paul T.A., Bies J., Small D., Wolff L. Signatures of polycomb repression and reduced H3K4 trimethylation are associated with p15INK4b DNA methylation in AML. Blood 2010, 115:3098-3108.
    • (2010) Blood , vol.115 , pp. 3098-3108
    • Paul, T.A.1    Bies, J.2    Small, D.3    Wolff, L.4
  • 90
    • 84861892178 scopus 로고    scopus 로고
    • RNA-dependent inhibition of ribonucleotide reductase is a major pathway for 5-azacytidine activity in acute myeloid leukemia
    • Aimiuwu J., Wang H., Chen P., Xie Z., Wang J., Liu S., et al. RNA-dependent inhibition of ribonucleotide reductase is a major pathway for 5-azacytidine activity in acute myeloid leukemia. Blood 2012, 119:5229-5238.
    • (2012) Blood , vol.119 , pp. 5229-5238
    • Aimiuwu, J.1    Wang, H.2    Chen, P.3    Xie, Z.4    Wang, J.5    Liu, S.6
  • 91
    • 84893698475 scopus 로고    scopus 로고
    • National Cancer Institute SEER Cancer Statistics Review 1975-2009
    • National Cancer Institute SEER Cancer Statistics Review 1975-2009 http://seer.cancer.gov/csr/1975_2009_pops09/.
  • 92
    • 84863393263 scopus 로고    scopus 로고
    • Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
    • Patel J.P., Gonen M., Figueroa M.E., Fernandez H., Sun Z., Racevskis J., et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med 2012, 366:1079-1089.
    • (2012) N Engl J Med , vol.366 , pp. 1079-1089
    • Patel, J.P.1    Gonen, M.2    Figueroa, M.E.3    Fernandez, H.4    Sun, Z.5    Racevskis, J.6
  • 94
    • 78650172030 scopus 로고    scopus 로고
    • Prognostic factors for response and overall survival in 282 patients with higher-risk myelodysplastic syndromes treated with azacitidine
    • Itzykson R., Thepot S., Quesnel B., Dreyfus F., Beyne-Rauzy O., Turlure P., et al. Prognostic factors for response and overall survival in 282 patients with higher-risk myelodysplastic syndromes treated with azacitidine. Blood 2011, 117:403-411.
    • (2011) Blood , vol.117 , pp. 403-411
    • Itzykson, R.1    Thepot, S.2    Quesnel, B.3    Dreyfus, F.4    Beyne-Rauzy, O.5    Turlure, P.6
  • 95
    • 0017254616 scopus 로고
    • Combination chemotherapy of L1210 leukemia with 1-beta-D-arabinofuranosylcytosine and 5-azacytidine
    • Neil G.L., Berger A.E., Bhuyan B.K., DeSante D.C. Combination chemotherapy of L1210 leukemia with 1-beta-D-arabinofuranosylcytosine and 5-azacytidine. Cancer Res 1976, 36:1114-1120.
    • (1976) Cancer Res , vol.36 , pp. 1114-1120
    • Neil, G.L.1    Berger, A.E.2    Bhuyan, B.K.3    DeSante, D.C.4
  • 96
    • 0025978611 scopus 로고
    • Induction of deoxycytidine kinase by 5-azacytidine in an HL-60 cell line resistant to arabinosylcytosine
    • Kong X.B., Tong W.P., Chou T.C. Induction of deoxycytidine kinase by 5-azacytidine in an HL-60 cell line resistant to arabinosylcytosine. Mol Pharmacol 1991, 39:250-257.
    • (1991) Mol Pharmacol , vol.39 , pp. 250-257
    • Kong, X.B.1    Tong, W.P.2    Chou, T.C.3
  • 97
    • 0024355064 scopus 로고
    • Pharmacodynamic and DNA methylation studies of high-dose 1-beta-D-arabinofuranosyl cytosine before and after in vivo 5-azacytidine treatment in pediatric patients with refractory acute lymphocytic leukemia
    • Avramis V.I., Mecum R.A., Nyce J., Steele D.A., Holcenberg J.S. Pharmacodynamic and DNA methylation studies of high-dose 1-beta-D-arabinofuranosyl cytosine before and after in vivo 5-azacytidine treatment in pediatric patients with refractory acute lymphocytic leukemia. Cancer Chemother Pharmacol 1989, 24:203-210. 10.1007/BF00257619.
    • (1989) Cancer Chemother Pharmacol , vol.24 , pp. 203-210
    • Avramis, V.I.1    Mecum, R.A.2    Nyce, J.3    Steele, D.A.4    Holcenberg, J.S.5
  • 98
    • 84871769515 scopus 로고    scopus 로고
    • Feasibility of azacitidine added to standard chemotherapy in older patients with acute myeloid leukemia - a randomised SAL pilot study
    • Krug U., Koschmieder A., Schwammbach D., Gerss J., Tidow N., Steffen B., et al. Feasibility of azacitidine added to standard chemotherapy in older patients with acute myeloid leukemia - a randomised SAL pilot study. PLoS One 2012, 7(12):e52695. 10.1371/journal.pone.0052695.
    • (2012) PLoS One , vol.7 , Issue.12
    • Krug, U.1    Koschmieder, A.2    Schwammbach, D.3    Gerss, J.4    Tidow, N.5    Steffen, B.6
  • 99
    • 84893672152 scopus 로고    scopus 로고
    • Disease response and survival outcomes in acute myeloid leukemia (AML) patients unfit for chemotherapy treated with 10-day decitabine as initial therapy [abstract]
    • Gourdin T.S., Bhatnagar B., Duffy A.P., Tidwell M., Ning Y., Sausville E.A., et al. Disease response and survival outcomes in acute myeloid leukemia (AML) patients unfit for chemotherapy treated with 10-day decitabine as initial therapy [abstract]. J Clin Oncol 2012, 30(Suppl. 15):611.
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL. 15 , pp. 611
    • Gourdin, T.S.1    Bhatnagar, B.2    Duffy, A.P.3    Tidwell, M.4    Ning, Y.5    Sausville, E.A.6
  • 100
    • 84893645452 scopus 로고    scopus 로고
    • High response rate and prolonged survival in patients with primary refractory acute myelogenous leukemia treated with decitabine salvage therapy [abstract]
    • Fernandez A., Shah D., Liu D., Ahmed N., Lulaj E., Seiter K. High response rate and prolonged survival in patients with primary refractory acute myelogenous leukemia treated with decitabine salvage therapy [abstract]. Blood 2011, 118(21):4280.
    • (2011) Blood , vol.118 , Issue.21 , pp. 4280
    • Fernandez, A.1    Shah, D.2    Liu, D.3    Ahmed, N.4    Lulaj, E.5    Seiter, K.6


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