Mesenchymal stem cell transplantation reduces glial cyst and improves functional outcome after spinal cord compression

World Neurosurgery

Volumn 81, Issue 1, 2014, Pages 183-190

  Boido, Marina ^a   Garbossa, Diego ^a   Fontanella, Marco ^a   Ducati, Alessandro ^a   Vercelli, Alessandro ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Cell therapy; Central nervous system repair; Functional recovery

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BODY POSTURE; CELL ACTIVATION; CELL SURVIVAL; CONTROLLED STUDY; DISEASE MODEL; ENGRAFTMENT; EXPERIMENTAL BEHAVIORAL TEST; FOOT; FUNCTIONAL STATUS; GLIAL CYST; HINDLIMB; LIMB MOVEMENT; MACROGLIA; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MICROGLIA; MOUSE; MYELITIS; NONHUMAN; REVIEW; SENSORIMOTOR FUNCTION; SPINAL CORD COMPRESSION; SPINAL CORD CYST; THERAPY EFFECT; TREATMENT OUTCOME; ADULT; ARTICLE; ASTROCYTE; ASTROCYTOSIS; BRAIN CYST; CELLULAR DISTRIBUTION; OUTCOME ASSESSMENT;

CELL THERAPY; CENTRAL NERVOUS SYSTEM REPAIR; FUNCTIONAL RECOVERY;

ANIMALS; ASTROCYTES; BEHAVIOR, ANIMAL; CELL SEPARATION; CELLS, CULTURED; CYSTS; FLUORESCENT ANTIBODY TECHNIQUE; GLIOSIS; GRAFT SURVIVAL; HINDLIMB; IMMUNOHISTOCHEMISTRY; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED C57BL; MICROGLIA; POSTURE; PSYCHOMOTOR PERFORMANCE; SENSATION; SPINAL CORD COMPRESSION; TREATMENT OUTCOME;

EID: 84893692716     PISSN: 18788750     EISSN: 18788769     Source Type: Journal    
DOI: 10.1016/j.wneu.2012.08.014     Document Type: Review

References (41)

1. M.F. Azari, L. Mathias, E. Ozturk, D.S. Cram, R.L. Boyd, and S. Petratos Mesenchymal stem cells for treatment of CNS injury Curr Neuropharmacol 8 2010 316 323
2. M. Boido, D. Garbossa, and A. Vercelli Early graft of neural precursors in spinal cord compression reduces glial cyst and improves function J Neurosurg Spine 15 2011 97 106
3. M. Boido, R. Rupa, D. Garbossa, M. Fontanella, A. Ducati, and A. Vercelli Embryonic and adult stem cells promote raphespinal axon outgrowth and improve functional outcome following spinal hemisection in mice Eur J Neurosci 30 2009 833 846
4. A.J. Bruce-Keller Microglial-neuronal interactions in synaptic damage and recovery J Neurosci Res 58 1999 191 201 (Pubitemid 29463703)
5. M. Coutts, and H.S. Keirstead Stem cells for the treatment of spinal cord injury Exp Neurol 209 2008 368 377 (Pubitemid 351181429)
6. A.P. Croft, and S.A. Przyborski Formation of neurons by non-neural adult stem cells: potential mechanism implicates an artifact of growth in culture Stem Cells 24 2006 1841 1851 (Pubitemid 44474160)
7. J.E. Davies, C. Huang, C. Proschel, M. Noble, M. Mayer-Proschel, and S.J. Davies Astrocytes derived from glial-restricted precursors promote spinal cord repair J Biol 5 2006 7
8. R.J. Dumont, D.O. Okonkwo, S. Verna, R.J. Hurlbert, P.T. Boulos, D.B. Ellegala, and A.S. Dumont Acute spinal cord injury, part I: pathophysiologic mechanisms Clin Neuropharmacol 24 2001 254 264 (Pubitemid 32906712)
9. M. Farooque Spinal cord compression injury in the mouse: presentation of a model including assessment of motor dysfunction Acta Neuropathol 100 2000 13 22 (Pubitemid 30352863)
10. J.R. Faulkner, J.E. Herrmann, M.J. Woo, K.E. Tansey, N.B. Doan, and M.V. Sofroniew Reactive astrocytes protect tissue and preserve function after spinal cord injury J Neurosci 24 2004 2143 2155 (Pubitemid 38314546)
11. S. Garbuzova-Davis, A.E. Willing, S. Saporta, P.C. Bickford, C. Gemma, N. Chen, C.D. Sanberg, S.K. Klasko, C.V. Borlongan, and P.R. Sanberg Novel cell therapy approaches for brain repair Prog Brain Res 157 2006 207 222 (Pubitemid 44566489)
12. J.H. Garcia, S. Wagner, K.F. Liu, and X.J. Hu Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats Stroke 26 1995 627 634
13. S. Gögel, M. Gubernator, and S.L. Minger Progress and prospects: stem cells and neurological diseases Gene Ther 18 2011 1 6
14. W. Gu, F. Zhang, Q. Xue, Z. Ma, P. Lu, and B. Yu Transplantation of bone marrow mesenchymal stem cells reduces lesion volume and induces axonal regrowth of injured spinal cord Neuropathology 30 2010 205 217
15. S.A. Hardy, D.J. Maltman, and S.A. Przyborski Mesenchymal stem cells as mediators of neural differentiation Curr Stem Cell Res Ther 3 2008 43 52 (Pubitemid 352024866)
16. C.P. Hofstetter, N.A. Holmström, J.A. Lilja, P. Schweinhardt, J. Hao, C. Spenger, Z. Wiesenfeld-Hallin, S.N. Kurpad, J. Frisén, and L. Olson Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome Nat Neurosci 8 2005 346 353 (Pubitemid 40300192)
17. N. Joyce, G. Annett, L. Wirthlin, S. Olson, G. Bauer, and J.A. Nolta Mesenchymal stem cells for the treatment of neurodegenerative disease Regen Med 5 2010 933 946
18. S. Karimi-Abdolrezaee, E. Eftekharpour, J. Wang, C.M. Morshead, and M.G. Fehlings Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury J Neurosci 26 2006 3377 3389
19. E. Keimpema, M.R. Fokkens, Z. Nagy, V. Agoston, P.G. Luiten, C. Nyakas, H.W. Boddeke, and J.C. Copray Early transient presence of implanted bone marrow stem cells reduces lesion size after cerebral ischaemia in adult rats Neuropathol Appl Neurobiol 35 2009 89 102
20. V.R. King, J.B. Phillips, H. Hunt-Grubbe, R. Brown, and J.V. Priestley Characterization of non-neuronal elements within fibronectin mats implanted into the damaged adult rat spinal cord Biomaterials 27 2006 485 496 (Pubitemid 41457251)
21. M. Lalancette-Hebert, G. Gowing, A. Simard, Y.C. Weng, and J. Kriz Selective ablation of proliferating microglial cells exacerbates ischaemic injury in the brain J Neurosci 27 2007 2596 2605 (Pubitemid 46393607)
22. M.A. Lynch The multifaceted profile of activated microglia Mol Neurobiol 40 2009 139 156
23. M.Y. Macias, M.B. Syring, M.A. Pizzi, M.J. Crowe, A.R. Alexanian, and S.N. Kurpad Pain with no gain: allodynia following neural stem cell transplantation in spinal cord injury Exp Neurol 201 2006 335 348 (Pubitemid 44344226)
24. K. Mareschi, M. Novara, D. Rustichelli, I. Ferrero, D. Guido, E. Carbone, E. Medico, E. Madon, A. Vercelli, and F. Fagioli Neural differentiation of human mesenchymal stem cells: evidence for expression of neural markers and eag K+ channel types Exp Hematol 34 2006 1563 1572 (Pubitemid 44566419)
25. J.W. McDonald, and C. Sadowsky Spinal-cord injury Lancet 359 2002 417 425 (Pubitemid 34158956)
26. T.M. Myckatyn, S.E. Mackinnon, and J.W. McDonald Stem cell transplantation and other novel techniques for promoting recovery from spinal cord injury Transpl Immunol 12 2004 343 358 (Pubitemid 38639728)
27. D.J. Myer, G.G. Gurkoff, S.M. Lee, D.A. Hovda, and M.V. Sofroniew Essential protective roles of reactive astrocytes in traumatic brain injury Brain 129 2006 2761 2772 (Pubitemid 44523749)
28. B. Neuhuber, B. Timothy Himes, J.S. Shumsky, and G. Gallo Fischer I: Axon growth and recovery of function supported by human bone marrow stromal cells in the injured spinal cord exhibit donor variations Brain Res 1035 2005 73 85 (Pubitemid 40248539)
29. Y. Nishio, M. Koda, T. Kamada, Y. Someya, K. Yoshinaga, S. Okada, H. Harada, A. Okawa, H. Moriya, and M. Yamazaki The use of hemopoietic stem cells derived from human umbilical cord blood to promote restoration of spinal cord tissue and recovery of hindlimb function in adult rats J Neurosurg Spine 5 2006 424 433 (Pubitemid 47325353)
30. M. Okabe, M. Ikawa, K. Kominami, T. Nakanishi, and Y. Nishimune 'Green mice' as a source of ubiquitous green cells FEBS Lett 407 1997 313 319 (Pubitemid 27199450)
31. A.M. Parr, C.H. Tator, and A. Keating Bone marrow-derived mesenchymal stromal cells for the repair of central nervous system injury Bone Marrow Transplant 40 2007 609 619 (Pubitemid 47456475)
32. N. Pitsikas, A. Brambilla, C. Besozzi, P. Bonali, F. Fodritto, N. Grippa, A. Scandroglio, and F. Borsini Effects of cerestat and NBQX on functional and morphological outcomes in rat focal cerebral ischemia Pharmacol Biochem Behav 68 2001 443 447 (Pubitemid 32452399)
33. M.F. Pittenger, A.M. Mackay, S.C. Beck, R.K. Jaiswal, R. Douglas, J.D. Mosca, M.A. Moorman, D.W. Simonetti, S. Craig, and D.R. Marshak Multilineage potential of adult human mesenchymal stem cells Science 284 1999 143 147 (Pubitemid 29282067)
34. F. Renault-Mihara, S. Okada, S. Shibata, M. Nakamura, Y. Toyama, and H. Okano Spinal cord injury: emerging beneficial role of reactive astrocytes migration Int J Biochem Cell Biol 40 2008 1649 1653
35. J. Sanchez-Ramos, S. Song, F. Cardozo-Pelaez, C. Hazzi, T. Stedeford, A. Willing, T.B. Freeman, S. Saporta, W. Janssen, N. Patel, D.R. Cooper, and P.R. Sanberg Adult bone marrow stromal cells differentiate into neural cells in vitro Exp Neurol 164 2000 247 256 (Pubitemid 32008970)
36. H. Takamatsu, M. Tatsumi, S. Nitta, R. Ichise, K. Muramatsu, M. Iida, S. Nishimura, and K. Umemura Time courses of progress to the chronic stage of middle cerebral artery occlusion models in rats Exp Brain Res 146 2002 95 102 (Pubitemid 34985332)
37. S. Thuret, L.D.F. Moon, and F.H. Gage Therapeutic interventions after spinal cord injury Nat Rev Neurosci 7 2006 628 643 (Pubitemid 44106745)
38. M. Yang, X. Wei, J. Li, L.A. Heine, R. Rosenwasser, and L. Iacovitti Changes in host blood factors and brain glia accompanying the functional recovery after systemic administration of bone marrow stem cells in ischemic stroke rats Cell Transplant 19 2010 1073 1084
39. J.R. Wrathall Spinal cord injury models J Neurotrauma 9 Suppl 1 1992 S129 S134
40. K.T. Wright, W. El Masri, A. Osman, J. Chowdhury, and W.E. Johnson Bone marrow for the treatment of spinal cord injury: mechanisms and clinical applications Stem Cells 29 2011 169 178
41. L. Zhang, T. Schallert, Z.G. Zhang, Q. Jiang, P. Arniego, Q. Li, M. Lu, and M. Chopp A test for detecting long-term sensorimotor dysfunction in the mouse after focal cerebral ischemia J Neurosci Methods 117 2002 207 214 (Pubitemid 34721338)