A meta-analysis of temozolomide versus radiotherapy in elderly glioblastoma patients

Journal of Neuro-Oncology

Volumn 116, Issue 2, 2014, Pages 315-324

  Yin, An An ^a   Cai, Sang ^b   Dong, Yu ^c   Zhang, Lu Hua ^a   Liu, Bo Lin ^a   Cheng, Jin Xiang ^a   Zhang, Xiang ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b The 101 Hospital of Chinese PLA   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Elderly glioblastoma patients; Meta analysis; O6 methylguanine DNA methyltransferase; Radiotherapy; Temozolomide

Indexed keywords

LIVER ENZYME; LOMUSTINE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; NITROSOUREA; PROCARBAZINE; TEMOZOLOMIDE;

AGED; ARTICLE; ASTHENIA; BLOOD TOXICITY; BRAIN HEMORRHAGE; CANCER PATIENT; CANCER RADIOTHERAPY; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DRUG TOLERABILITY; FATIGUE; FEMALE; GLIOBLASTOMA; HUMAN; INFECTION; LOSS OF APPETITE; LYMPHOCYTOPENIA; MAJOR CLINICAL STUDY; MALE; META ANALYSIS; MONOTHERAPY; NAUSEA; NEUROLOGIC DISEASE; NEUTROPENIA; OVERALL SURVIVAL; PANCYTOPENIA; PHASE 3 CLINICAL TRIAL; PROGRESSION FREE SURVIVAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SEIZURE; SENSITIVITY ANALYSIS; SKIN TOXICITY; THROMBOCYTOPENIA; THROMBOEMBOLISM; UNSPECIFIED SIDE EFFECT; VOMITING;

AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS, ALKYLATING; BRAIN NEOPLASMS; DACARBAZINE; DATABASES, BIBLIOGRAPHIC; GLIOBLASTOMA; HUMANS; OUTCOME ASSESSMENT (HEALTH CARE); RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84893679134     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-013-1294-0     Document Type: Article

References (28)

1. Wen PY, Kesari S (2008) Malignant gliomas in adults. N Engl J Med 359:492-507
2. Laperriere N, Weller M, Stupp R, Perry JR, Brandes AA et al (2012) Optimal management of elderly patients with glioblastoma. Cancer Treat Rev. doi: 10.1016/j.ctrv.2012.05.008
3. Iwamoto FM, Reiner AS, Panageas KS, Elkin EB, Abrey LE (2008) Patterns of care in elderly glioblastoma patients. Ann Neurol 64:628-634
4. Kita D, Ciernik IF, Vaccarella S, Franceschi S, Kleihues P et al (2009) Age as a predictive factor in glioblastomas: population-based study. Neuroepidemiology 33:17-22
5. Yin AA, Cheng JX, Zhang X, Liu BL (2013) The treatment of glioblastomas: a systematic update on clinical phase III trials. Crit Rev Oncol Hematol. doi: 10.1016/j.critrevonc.2013.01.007
6. Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B et al (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352:987-996
7. Keime-Guibert F, Chinot O, Taillandier L, Cartalat-Carel S, Frenay M et al (2007) Radiotherapy for glioblastoma in the elderly. N Engl J Med 356:1527-1535
8. Macdonald DR, Cascino TL, Schold SJ, Cairncross JG (1990) Response criteria for phase II studies of supratentorial malignant glioma. J Clin Oncol 8:1277-1280
9. Higgins JP, Green S (2013) Cochrane handbook for systematic reviews of interventions. http://handbook.cochrane.org/. Accessed 5 Jan 2013
10. Egger M, Davey SG, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629-634
11. Glantz M, Chamberlain M, Liu Q, Litofsky NS, Recht LD (2003) Temozolomide as an alternative to irradiation for elderly patients with newly diagnosed malignant gliomas. Cancer 97:2262-2266
12. Laigle-Donadey F, Figarella-Branger D, Chinot O, Taillandier L, Cartalat-Carel S et al (2010) Up-front temozolomide in elderly patients with glioblastoma. J Neurooncol 99:89-94
13. Malmstrom A, Gronberg BH, Marosi C, Stupp R, Frappaz D et al (2012) Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trial. Lancet Oncol 13:916-926
14. Reifenberger G, Hentschel B, Felsberg J, Schackert G, Simon M et al (2012) Predictive impact of MGMT promoter methylation in glioblastoma of the elderly. Int J Cancer 131:1342-1350
15. Wick W, Platten M, Meisner C, Felsberg J, Tabatabai G et al (2012) Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial. Lancet Oncol 13:707-715
16. Caroli M, Vetrano IG, Lucarella F, Di Cristofori A, Pluder M et al (2011) Treatment of cerebral glioblastoma in elderly patients. Eur J Cancer 47(Suppl 1):S581
17. Chamberlain MC, Chalmers L (2007) A pilot study of primary temozolomide chemotherapy and deferred radiotherapy in elderly patients with glioblastoma. J Neurooncol 82:207-209
18. Chinot OL, Barrie M, Frauger E, Dufour H, Figarella-Branger D et al (2004) Phase II study of temozolomide without radiotherapy in newly diagnosed glioblastoma multiforme in an elderly populations. Cancer 100:2208-2214
19. Gallego PJ, Ducray F, Chinot O, Catry-Thomas I, Taillandier L et al (2011) Temozolomide in elderly patients with newly diagnosed glioblastoma and poor performance status: an ANOCEF phase II trial. J Clin Oncol 29:3050-3055
20. Guidance for Industry Non-Inferiority Clinical Trials (Draft) (2011) http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/ Guidances/UCM202140.pdf. Accessed 3 Mar 2013
21. Berghoff AS, Preusser M (2012) Clinical neuropathology practice guide 06-2012: MGMT testing in elderly glioblastoma patients - Yes, but how? Clin Neuropathol 31:405-408
22. Weller M, Stupp R, Reifenberger G, Brandes AA, van den Bent MJ et al (2010) MGMT promoter methylation in malignant gliomas: Ready for personalized medicine? Nat Rev Neurol 6:39-51
23. Yin AA, Zhang LH, Cheng JX, Dong Y, Liu BL et al (2013) Radiotherapy plus concurrent or sequential temozolomide for glioblastoma in the elderly: a meta-analysis. PLoS ONE. doi: 10.1371/journal.pone.0074242
24. Perry JR, O'Callaghan CJ, Ding K, Roa W, Mason WP et al (2012) A phase III randomized controlled trial of short-course radiotherapy with or without concomitant and adjuvant temozolomide in elderly patients with glioblastoma. J Clin Oncol 30(Suppl):S2104
25. Mathiesen T (2012) Population-based data: the impact on glioma treatment for elderly patients. World Neurosurg 78:426-427
26. Brada M, Stenning S, Gabe R, Thompson LC, Levy D et al (2010) Temozolomide versus procarbazine, lomustine, and vincristine in recurrent high-grade glioma. J Clin Oncol 28:4601-4608
27. Gilbert MR, Wang M, Aldape KD, Stupp R, Hegi M et al (2006) A randomized phase III trial comparing standard adjuvant temozolomide (TMZ) with a dose-dense (dd) schedule in newly diagnosed glioblastoma (GBM). J Clin Oncol 29(Suppl):2006
28. Fiorentino A, Balducci M, Chiesa S, Fusco V (2012) Elderly people with glioblastoma. Lancet Oncol 13:e327-e329