Increased expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental Rickettsia conorii infection

BMC Infectious Diseases

Volumn 14, Issue 1, 2014, Pages

  Astrup, Elisabeth ^a,b   Ranheim, Trine ^b,e   Damås, Jan K ^f,g   Davì, Giovanni ^h   Santilli, Francesca ^h   Jensenius, Mogens ^d   Vitale, Giustina ⁱ   Aukrust, Pål ^b,c,e   Olano, Juan P ^j   Otterdal, Kari ^b,e  

^a AKERSHUS UNIVERSITY HOSPITAL   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

^d ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^e UNIVERSITY OF OSLO   (Norway)

^f NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^g TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^h UNIVERSITY OF CHIETI   (Italy)

ⁱ UNIVERSITY OF PALERMO   (Italy)

^j University of Texas Medical Branch School of Medicine   (United States)

more..

Author keywords

CCR7; Chemokines; Inflammation; R. africae; R. conorii

Indexed keywords

ADULT; AGED; ANIMALS; CHEMOKINE CCL19; CHEMOKINE CCL21; FEMALE; HOMEOSTASIS; HUMANS; MALE; MICE; MICE, INBRED C3H; MIDDLE AGED; RECEPTORS, CCR7; RICKETTSIA CONORII; RICKETTSIA INFECTIONS; UP-REGULATION; YOUNG ADULT;

EID: 84893663349     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-14-70     Document Type: Article

References (24)

1. Parola P, Paddock CD, Raoult D. Tick-borne rickettsioses around the world: emerging diseases challenging old concepts. Clin Microbiol Rev 2005, 18:719-756. 10.1128/CMR.18.4.719-756.2005, 1265907, 16223955.
2. Walker DH, Ismail N. Emerging and re-emerging rickettsioses: endothelial cell infection and early disease events. Nat Rev Microbiol 2008, 6:375-386. 10.1038/nrmicro1866, 18414502.
3. Mansueto P, Vitale G, Cascio A, Seidita A, Pepe I, Carroccio A, di Rosa S, Rini GB, Cillari E, Walker DH. New insight into immunity and immunopathology of rickettsial disease. Clin Dev Immunol 2012, 2012:967852. 3170826, 21912565.
4. Forster R, Davalos-Misslitz AC, Rot A. CCR7 and its ligands: balancing immunity and tolerance. Nat Rev Immunol 2008, 8:362-371. 10.1038/nri2297, 18379575.
5. Noor S, Wilson EH. Role of CC chemokine receptor type 7 and its ligands during neuroinflammation. J Neuroinflammation 2012, 9:77. 10.1186/1742-2094-9-77, 3413568, 22533989.
6. Moschovakis GL, Förster R. Multifaceted activities of CCR7 regulate T-cell homeostasis in health and disease. Eur J Immunol 2012, 42:1949-1955. 10.1002/eji.201242614, 22700449.
7. Kaur D, Saunders R, Berger P, Siddiqui S, Woodman L, Wardlaw A, Bradding P, Brightling CE. Airway smooth muscle and mast cell-derived CC chemokine ligand 19 mediate airway smooth muscle migration in asthma. Am J Respir Crit Care Med 2006, 174:1179-1188. 10.1164/rccm.200603-394OC, 16959919.
8. Damås JK, Smith C, Oie E, Fevang B, Halvorsen B, Wæhre T, Boullier A, Breland U, Yndestad A, Ovchinnikova O, Robertson AK, Sandberg WJ, Kjekshus J, Taskén K, Frøland SS, Gullestad L, Hansson GK, Quehenberger O, Aukrust P. Enhanced expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental atherosclerosis: possible pathogenic role in plaque destabilization. Arterioscler Thromb Vasc Biol 2007, 27:614-620. 10.1161/01.ATV.0000255581.38523.7c, 17170367.
9. Pickens SR, Chamberlain ND, Volin MV, Pope RM, Talarico NE, Mandelin AM, Shahrara S. Role of the CCL21 and CCR7 pathways in rheumatoid arthritis angiogenesis. Arthritis Rheum 2012, 64:2471-2481. 10.1002/art.34452, 3409328, 22392503.
10. Jensenius M, Ueland T, Fournier PE, Brosstad F, Stylianou E, Vene S, Myrvang B, Raoult D, Aukrust P. Systemic inflammatory responses in African tick bite fever. J Infect Dis 2003, 187:1332-1336. 10.1086/368415, 12696016.
11. Damås JK, Davì G, Jensenius M, Santilli F, Otterdal K, Ueland T, Flo TH, Lien E, Espevik T, Frøland SS, Vitale G, Raoult D, Aukrust P. Relative chemokine and adhesion molecule expression in Mediterranean spotted fever and African tick bite fever. J Infect 2009, 58:68-75. 10.1016/j.jinf.2008.11.008, 19091423.
12. Valbuena G, Bradford W, Walker DH. Expression analyses of the T-cell targeting chemokines CXCL9 and CXCL10 in mice and humans with endothelial infection caused by rickettsiae of the spotted fever group. Am J Pathol 2003, 163:1357-1369. 10.1016/S0002-9440(10)63494-3, 1868304, 14507644.
13. Valbuena G, Walker DH. Expression of CX3CL1 (fractalkine) in mice with endothelial-target rickettsial infection of the spotted fever group. Virchows Arch 2005, 446:21-27. 10.1007/s00428-004-1120-3, 15480764.
14. Rydkina E, Sahni A, Silverman DJ, Sahni SK. Comparative analysis of host-cell signalling mechanisms activated in response to infection with Rickettsia conorii and Rickettsia typhi. J Med Microbiol 2007, 56:896-906. 10.1099/jmm.0.47050-0, 17577053.
15. Kaplanski G, Teysseire N, Farnarier C, Kaplanski S, Lissitzky JC, Durand JM, Soubeyrand J, Dinarello CA, Bongrand P. IL-6 and IL-8 production from cultured human endothelial cells stimulated by infection with Rickettsia conorii via a cell-associated IL-1 alpha-dependent pathway. J Clin Invest 1995, 96:2839-2844. 10.1172/JCI118354, 185994, 8675654.
16. Saleh S, Solomon A, Wightman F, Xhilaga M, Cameron PU, Lewin SR. CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 latency. Blood 2007, 110:4161-4164. 10.1182/blood-2007-06-097907, 17881634.
17. Damås JK, Oktedalen O, Ueland T, Landrø L, Barstad J, Müller F, Frøland SS, Flo TH, Aukrust P. Enhanced levels of CCL19 in patients with advanced aquired immune deficiency syndrome. Clin Exp Immunol 2012, 167:492-498. 10.1111/j.1365-2249.2011.04524.x, 3374281, 22288592.
18. Rollag H, Ueland T, Åsberg A, Hartmann A, Jardine AG, Humar A, Pescovitz MD, Bignamini AA, Aukrust P. Characterization of cytomegalovirus disease in solid organ transplant recipients by markers of inflammation in plasma. PLoS One 2013, 8:e60767. 10.1371/journal.pone.0060767, 3620537, 23593305.
19. Yu Y, Zhang Y, Hu S, Jin D, Chen X, Jin Q, Liu H. Different patterns of cytokines and chemokines combined with IFN-γ production reflect Mycobacterium tuberculosis infection and disease. PLoS One 2013, 8:e60767. 10.1371/journal.pone.0060767, 3620537, 23593305.
20. Olmos S, Stukes S, Ernst JD. Ectopic activation of Mycobacterium tuberculosis-specific CD4+ T cells in lungs of CCR7-/- mice. J Immunol 2010, 184:895-901. 10.4049/jimmunol.0901230, 2879893, 20007536.
21. Jang S, Smit J, Kallal LE, Lukacs NW. Respiratory syncytial virus infection modifies and accelerates pulmonary disease via DC activation and migration. J Leukoc Biol 2013, 94:5-15. 10.1189/jlb.0412195, 23293372.
22. Damås JK, Landrø L, Fevang B, Heggelund L, Tjønnfjord GE, Fløisand Y, Halvorsen B, Frøland SS, Aukrust P. The homeostatic chemokines CCL19 and CCL21 promote inflammation in human immunodeficiency virus-infected patients with ongoing viral replication. Clin Exp Immunol 2009, 157:400-407. 10.1111/j.1365-2249.2009.03976.x, 2745035, 19664149.
23. Choi JH, Cheong TC, Ha NY, Ko Y, Cho CH, Jeon JH, So I, Kim IK, Choi MS, Kim IS, Cho NH. Orienta tsutsugamushi subverts dendritic cell function by escaping from autophagy and impairing their migration. PLoS Negl Trop Dis 2013, 7:e1981. 10.1371/journal.pntd.0001981, 3536799, 23301113.
24. Oteo JA, Portillo A. Tick-borne rickettsioses in Europe. Ticks Tick Borne Dis 2012, 3:271-278. 10.1016/j.ttbdis.2012.10.035, 23177355.