Enhanced levels of CCL19 in patients with advanced acquired immune deficiency syndrome (AIDS)

Clinical and Experimental Immunology

Volumn 167, Issue 3, 2012, Pages 492-498

  Damas J K ^a,b   Oktedalen O ^c   Ueland, T ^d   Landro L ^d   Barstad, J ^c   Muller F ^d,e   Froland S S ^d,e   Flo, T H ^b   Aukrust, P ^d,e  

^a TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^c ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

^e UNIVERSITY OF OSLO   (Norway)

Author keywords

Anti retroviral therapy; Chemokine CCL19; Highly active; HIV; Mycobacterium avium

Indexed keywords

ANTIRETROVIRUS AGENT; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; SECONDARY LYMPHOID TISSUE CHEMOKINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ARTICLE; ATYPICAL MYCOBACTERIOSIS; CD4 LYMPHOCYTE COUNT; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; MALE; MORTALITY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ADULT; AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; BACTERIAL PROTEINS; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CHEMOKINE CCL19; CHEMOKINE CCL21; FEMALE; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; MYCOBACTERIUM AVIUM COMPLEX; MYCOBACTERIUM AVIUM-INTRACELLULARE INFECTION; PROGNOSIS;

EID: 84856397883     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2011.04524.x     Document Type: Article

References (16)

1. Förster R, Schubel A, Breitfeld D etal. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 1991; 99:23-33.
2. Müller G, Hopken UE, Lipp M. The impact of CCR7 and CXCR5 on lymphoid organ development and systemic immunity. Immunol Rev 2003; 195:117-35.
3. Marsland BJ, Bättig P, Bauer M etal. CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells. Immunity 2005; 22:493-505.
4. Aloisi F, Pujol-Borrell R. Lymphoid neogenesis in chronic inflammatory diseases. Nat Rev Immunol 2006; 6:205-17.
5. Burman A, Haworth O, Hardie DL etal. A chemokine-dependent stromal induction mechanism for aberrant lymphocyte accumulation and compromised lymphatic return in rheumatoid arthritis. J Immunol 2005; 174:1693-700.
6. Middel P, Raddatz D, Gunawan B etal. Increased number of mature dendritic cells in Crohn's disease: evidence for a chemokine mediated retention mechanism. Gut 2006; 55:220-7.
7. Damås JK, Smith C, Øie E etal. Enhanced expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental atherosclerosis: possible pathogenic role in plaque destabilization. Arterioscler Thromb Vasc Biol 2007; 27:614-20.
8. Choi YK, Fallert BA, Murphey-Corb MA etal. Simian immunodeficiency virus dramatically alters expression of homeostatic chemokines and dendritic cell markers during infection in vivo. Blood 2003; 101:1684-91.
9. Damås JK, Landrø L, Fevang B etal. Enhanced levels of the CCR7 ligands CCL19 and CCL21 in HIV infection: correlation with viral load, disease progression and response to highly active antiretroviral therapy. AIDS 2009; 2:135-8.
10. Karakousis PC, Moore RD, Chaisson RE. Mycobacterium avium complex in patients with HIV infection in the era of highly active antiretroviral therapy. Lancet Infect Dis 2004; 4:557-65.
11. Cosma CL, Sherman DR, Ramakrishnan L. The secret lives of the pathogenic mycobacteria. Annu Rev Microbiol 2003; 57:641-76.
12. Brenchley JM, Price DA, Schacker TW etal. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 2006; 12:1365-71.
13. Fonteneau JF, Larsson M, Beignon AS etal. Human immunodeficiency virus type 1 activates plasmacytoid dendritic cells and concomitantly induces the bystander maturation of myeloid dendritic cells. J Virol 2004; 78:5223-32.
14. Nagira M, Sato A, Miki S etal. Enhanced HIV-1 replication by chemokines constitutively expressed in secondary lymphoid tissues. Virology 1999; 264:422-6.
15. Damås JK, Landrø L, Fevang B etal. Homeostatic chemokines CCL19 and CCL21 promote inflammation in human immunodeficiency virus-infected patients with ongoing viral replication. Clin Exp Immunol 2009; 157:400-7.
16. Aukrust P, Müller F, Lien E etal. Tumor necrosis factor (TNF) system levels in human immunodeficiency virus-infected patients during highly active antiretroviral therapy: persistent TNF activation is associated with virologic and immunologic treatment failure. J Infect Dis 1999; 179:74-82.