Microvascular density of regenerative nodule to small hepatocellular carcinoma by automated analysis using CD105 and CD34 immunoexpression

BMC Cancer

Volumn 14, Issue 1, 2014, Pages

  Paschoal, Juliana P ^a   Bernardo, Vagner ^b   Canedo, Nathalie Henriques S ^a   Ribeiro, Osmar D ^a   Caroli Bottino, Adriana ^a   Pannain, Vera L ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b INSTITUTO NACIONAL DE CÂNCER   (Brazil)

Author keywords

CD105; CD34; Dysplastic nodule; Hepatocellular carcinoma; Microvascular density; Regenerative nodule

Indexed keywords

ANTIGENS, CD; ANTIGENS, CD34; AUTOMATION, LABORATORY; CARCINOMA, HEPATOCELLULAR; FOCAL NODULAR HYPERPLASIA; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER CIRRHOSIS; LIVER NEOPLASMS; LIVER REGENERATION; MICROVESSELS; NEOVASCULARIZATION, PATHOLOGIC; PREDICTIVE VALUE OF TESTS; RECEPTORS, CELL SURFACE; TUMOR MARKERS, BIOLOGICAL;

EID: 84893659652     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-14-72     Document Type: Article

References (35)

1. Ausprunk DH, Folkman J. Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis. Microvasc Res 1977, 15:53-65.
2. Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971, 285:1182-1186. 10.1056/NEJM197111182852108, 4938153.
3. Lyden D, Hattori K, Dias S, Costa C, Blaikie P, Butros L, Chadburn A, Heissig B, Marks W, Witte L, Wu Y, Hicklin D, Zhu Z, Hackett NR, Crystal RG, Moore MA, Hajjar KA, Manova K, Benezra R, Rafii S. Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nature Med 2001, 7:1194-1201. 10.1038/nm1101-1194, 11689883.
4. Ozalp S, Yalcin OT, Oner U, Tanir HM, Acikalin M, Sarac I. Microvasculardensity as a prognostic factor in preinvasive and invasive cervical lesions. Eur J Gynaecol Oncol 2003, 24:425-428.
5. Fisseler-Eckhoff A, Rothstein D, Müller KM. Neovascularization in hyperplastic, metaplastic and potentially preneoplastic lesions of the bronchial mucosa. Virchows Arch 1996, 429:95-100.
6. Staton CA, Chetwood AS, Cameron IC, Cross SS, Brown NJ, Reed MW. The angiogenic switch occurs at the adenoma stage of the adenoma carcinoma sequence in colorectal cancer. Gut 2007, 56:1426-1432. 10.1136/gut.2007.125286, 2000239, 17566019.
7. Vacca A, Ribatti D, Roncali L, Ranieri G, Serio G, Silvestris F, Dammacco F. Bone marrow angiogenesis and progression in multiple myeloma. Br J Haematol 1994, 87(3):503-508. 10.1111/j.1365-2141.1994.tb08304.x, 7527645.
8. Fox SB, Harris AL. Histological quantitation of tumour angiogenesis. APMIS 2004, 112:413-430. 10.1111/j.1600-0463.2004.apm11207-0803.x, 15563306.
9. Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N Engl J Med 1991, 324:1-8.
10. Korkolopoulou P, Viniou N, Kavantzas N, Patsouris E, Thymara I, Pavlopoulos PM, Terpos E, Stamatopoulos K, Plata E, Anargyrou K, Androulaki A, Davaris P, Yataganas X. Clinicopathologic correlations of bone marrow angiogenesis in chronic myeloid leukemia: a morphometric study. Leukemia 2003, 17:89-97. 10.1038/sj.leu.2402769, 12529665.
11. Heimburg S, Oehler MK, Papadopoulos T, Caffier H, Kristen P, Dietl J. Prognostic relevance of the endothelial marker CD34 in ovarian cancer. Anticancer Res 1999, 19:2527-2529.
12. Ho JW, Poon RT, Sun CK, Xue WC, Fan ST. Clinicopathological and prognostic implications of endoglin [CD105] expression in hepatocellular carcinoma and its adjacent non-tumorous liver. World J Gastroenterol 2005, 11:176-181.
13. Behrem S, Zarkovic K, Eskinja N, Jonjic N. Endoglin is a better marker than CD31 in evaluation of angiogenesis in glioblastoma. Croat Med J 2005, 46:417-422.
14. Minhajat R, Mori D, Yamasaki F, Sugita Y, Satoh T, Tokunaga O. Organ-specific endoglin [CD105] expression in the angiogenesis of human cancers. Pathol Int 2006, 56:717-723. 10.1111/j.1440-1827.2006.02037.x, 17096728.
15. Theuerkauf I, Zhou H, Fischer HP. Immunohistochemical patterns of human liver sinusoids under different conditions of pathologic perfusion. Virchows Arch 2001, 438:498-504. 10.1007/s004280000364, 11407479.
16. Barbara NP, Wrana JL, Letarte M. Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily. J Biol Chem 1999, 274:584-594. 10.1074/jbc.274.2.584, 9872992.
17. El-Gohary YM, Silverman JF, Olson PR, Liu YL, Cohen JK, Miller R, Saad RS. Endoglin [CD105] and vascular endothelial growth factor as prognostic markers in prostatic adenocarcinoma. Am J Clin Pathol 2007, 127:572-579. 10.1309/X6NXYE57DLUE2NQ8, 17369132.
18. Saad RS, Liu YL, Nathan G, Celebrezze J, Medich D, Silverman JF. Endoglin [CD105] and vascular endothelial growth factor as prognostic markers in colorectal cancer. Mod Pathol 2004, 17:197-203. 10.1038/modpathol.3800034, 14657950.
19. Park YN, Yang CP, Fernandez GJ, Cubukcu O, Thung SN, Theise ND. Neoangiogenesis and sinusoidal " capillarization" in dysplastic nodules of the liver. Am J Surg Pathol 1998, 22:656-662. 10.1097/00000478-199806000-00002, 9630172.
20. Yu D, Zhuang L, Sun X, Chen J, Yao Y, Meng K, Ding Y. Particular distribution and expression pattern of endoglin [CD105] in the liver of patients with hepatocellular carcinoma. BMC Cancer 2007, 7:122. 10.1186/1471-2407-7-122, 1941740, 17608955.
21. Nakamura T. Changes in expression of bile canalicular CD10 and CD105[endoglin] in peritumoral hepatic tissue. Tumori 2009, 95:495-500.
22. International Working Party Terminology of nodular hepatocellular lesions. Hepatology 1995, 22(3):983-993. International Working Party.
23. Bernardo V, Lourenço SQ, Cruz R, Monteiro-Leal LH, Silva LE, Camisasca DR, Farina M, Lins U. Reproducibility of immunostaining quantification and description of a new digital image processing procedure for quantitative evaluation of immunohistochemistry in pathology. Microsc Microanal 2009, 15:353-365. 10.1017/S1431927609090710, 19575836.
24. Nascimento C, Caroli-Bottino A, Paschoal J, Pannain VL. Vascular immunohistochemical markers: contributions to hepatocellular nodule diagnosis in explanted liver. Transplant Proc 2009, 41:4211-4213. 10.1016/j.transproceed.2009.09.068, 20005371.
25. Messerini L, Novelli L, Comin CE. Microvascular density and clinicopathological characteristics in hepatitis C virus and hepatitis B virus related hepatocellular carcinoma. J Clin Pathol 2004, 57:867-871. 10.1136/jcp.2003.015784, 1770375, 15280410.
26. Tanigawa N, Lu C, Mitsui T, Miura S. Quantitation of sinusoid-like vessels in hepatocellular carcinoma: its clinical and prognostic significance. Hepatology 1997, 26:1216-1223.
27. Yao Y, Pan Y, Chen J, Sun X, Qiu Y, Ding Y. Endoglin [CD105] expression in angiogenesis of primary hepatocellular carcinomas: analysis using tissue microarrays and comparisons with CD34 and VEGF. Ann Clin Lab Sci 2007, 37:39-48.
28. Chantrain CF, DeClerck YA, Groshen S, McNamara G. Computerized quantification of tissue vascularization using high-resolution slide scanning of whole tumor sections. J Histochem Cytochem 2003, 51:151-158. 10.1177/002215540305100203, 12533523.
29. Chebib I, Shabani-Rad MT, Chow MS, Zhang J, Gao ZH. Microvascular density and clinicopathologic characteristics in hepatocellular carcinoma with and without cirrhosis. Biomark Insights 2007, 14:59-68.
30. Dhillon AP, Colombari R, Savage K, Scheuer PJ. An immunohistochemical study of the blood vessels within primary hepatocellular tumours. Liver 1992, 12:311-318. 10.1055/s-2008-1040400, 1333033.
31. Yagmur E, Rizk M, Stanzel S, Hellerbrand C, Lammert F, Trautwein C, Wasmuth HE, Gressner AM. Elevation of endoglin [CD105] concentrations in serum of patients with liver cirrhosis and carcinoma. Eur J Gastroenterol Hepatol 2007, 19:755-761. 10.1097/MEG.0b013e3282202bea, 17700260.
32. Yang LY, Lu WQ, Huang GW, Huang GW, Wang W. Correlation between CD105 expression and postoperative recurrence and metastasis of hepatocellular carcinoma. BMC Cancer 2006, 6:110. 10.1186/1471-2407-6-110, 1475877, 16650286.
33. Li C, Issa R, Kumar P, Hampson IN, Lopez-Novoa JM, Bernabeu C, Kumar S. CD105 prevents apoptosis in hypoxic endothelial cells. J Cell Sci 2003, 116:2677-2685. 10.1242/jcs.00470, 12746487.
34. Chrobak I, Bujor A, Hant F, Mummery C, Ten Dijke P, Trojanowska M. Endoglin promotes TGF-beta/Smad1 signaling in scleroderma fibroblasts. J Cell Physiol 2011, 226:3340-3348. 10.1002/jcp.22690, 3381731, 21344387.
35. Quintanilla M, Ramirez JR, Pérez-Gómez E, Romero D, Velasco B, Letarte M, López-Novoa JM, Bernabéu C. Expression of the TGF-beta coreceptor endoglin in epidermal keratinocytes and its dual role in multistage mouse skin carcinogenesis. Oncogene 2003, 22:5976-5985. 10.1038/sj.onc.1206841, 12955076.