Enhancement of drug-specific lymphocyte proliferation using CD25 hi-depleted CD3+ effector cells

International Archives of Allergy and Immunology

Volumn 163, Issue 3, 2014, Pages 198-205

  Srinoulprasert, Yuttana ^a,b,c   Pichler, Werner J ^b,c  

^a MAHIDOL UNIVERSITY   (Thailand)

^b UNIVERSITY OF BERN   (Switzerland)

^c ADR AC GmbH   (Switzerland)

Author keywords

Drug hypersensitivity; Lymphocyte transformation test; Regulatory T cells

Indexed keywords

AMOXICILLIN; AMOXICILLIN PLUS CLAVULANIC ACID; CARBAMAZEPINE; COTRIMOXAZOLE; IOMEPROL; MEFENAMIC ACID; SULFAMETHOXAZOLE; TRANSCRIPTION FACTOR FOXP3; CD3 ANTIGEN;

ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS; ADULT; AGED; ANAPHYLAXIS; ANTIGEN PRESENTING CELL; ARTICLE; CD25+ T LYMPHOCYTE; CD3+ T LYMPHOCYTE; CELL ISOLATION; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; DRESS SYNDROME; DRUG HYPERSENSITIVITY; DRUG RESPONSE; EFFECTOR CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE TRANSFORMATION TEST; MACULOPAPULAR RASH; MALE; MIDDLE AGED; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SENSITIVITY AND SPECIFICITY; SKIN TEST; STEVENS JOHNSON SYNDROME; TOXIC EPIDERMAL NECROLYSIS; YOUNG ADULT; ALLERGIC REACTION; CELL FRACTIONATION; CELL SELECTION; DRUG SENSITIVITY; DRUG SPECIFICITY; IN VITRO STUDY; T CELL DEPLETION; T LYMPHOCYTE SUBPOPULATION;

ADULT; AGED; ANTIGENS, CD3; CELL PROLIFERATION; DRUG HYPERSENSITIVITY; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOLOGIC TECHNIQUES; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; YOUNG ADULT;

EID: 84893652873     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000358491     Document Type: Article

References (14)

1. Pichler WJ, Adam J, Daubner B, Gentinetta T, Keller M, Yerly D: Drug hypersensitivity reactions: pathomechanism and clinical symptoms. Med Clin North Am 2010; 94: 645-664.
2. Torres MJ, Sanchez-Sabate E, Alvarez J, Mayorga C, Fernandez J, Padial A, Cornejo-Garcia JA, Bellon T, Blanca M: Skin test evaluation in nonimmediate allergic reactions to penicillins. Allergy 2004; 59: 219-224.
3. Pichler WJ, Tilch J: The lymphocyte transformation test in the diagnosis of drug hypersensitivity. Allergy 2004; 59: 809-820.
4. Mayorga C, Torres MJ, Fernandez J, Canto G, Blanca M: Cutaneous symptoms in drug allergy: what have we learnt? Curr Opin Allergy Clin Immunol 2009; 9: 431-436.
5. Lochmatter P, Zawodniak A, Pichler WJ: In vitro tests in drug hypersensitivity diagnosis. Immunol Allergy Clin North Am 2009; 29: 537-554.
6. Cavani A, Nasorri F, Ottaviani C, Sebastiani S, De Pita O, Girolomoni G: Human CD25+ regulatory T cells maintain immune tolerance to nickel in healthy, nonallergic individuals. J Immunol 2003; 171: 5760-5768.
7. Daubner B, Groux-Keller M, Hausmann OV, Kawabata T, Naisbitt DJ, Park BK, Wendland T, Lerch M, Pichler WJ: Multiple drug hypersensitivity: normal Treg cell function but enhanced in vivo activation of drug-specific T cells. Allergy 2012; 67: 58-66.
8. Tang YH, Mockenhaupt M, Henry A, Bounoua M, Naldi L, Le Gouvello S, Bensussan A, Roujeau JC: Poor relevance of a lymphocyte proliferation assay in lamotrigine-induced Stevens-Johnson syndrome or toxic epidermal necrolysis. Clin Exp Allergy 2012; 42: 248-254.
9. Srinoulprasert Y, Chularojanamontri L, Pichler WJ: Lymphocyte transformation test in immune-mediated cutaneous adverse drug reactions. Siriraj Med J 2012; 64: 68-72.
10. Beeler A, Engler O, Gerber BO, Pichler WJ: Long-lasting reactivity and high frequency of drug-specific T cells after severe systemic drug hypersensitivity reactions. J Allergy Clin Immunol 2006; 117: 455-462.
11. Schnyder B, Adam J, Rauch A, Thurnheer MC, Pichler WJ: HLA-B*57:01 abacavir-naive individuals have specific T cells but no patch test reactivity. J Allergy Clin Immunol 2013; 132: 756-758.
12. Zawodniak A, Lochmatter P, Beeler A, Pichler WJ: Cross-reactivity in drug hypersensitivity reactions to sulfasalazine and sulfamethoxazole. Int Arch Allergy Immunol 2010; 153: 152-156.
13. Khalili B, Bahna SL: Pathogenesis and recent therapeutic trends in Stevens-Johnson syndrome and toxic epidermal necrolysis. Ann Allergy Asthma Immunol 2006; 97: 272-280; quiz 281-283, 320.
14. Schnyder B, Porebski G, Pichler WJ: Allergy workup of severe cutaneous adverse drug reactions: a light at the end of the tunnel? Br J Dermatol 2013; 168: 463-464.