Dose-related effects of statins on symptomatic intracerebral hemorrhage and outcome after thrombolysis for ischemic stroke

Stroke

Volumn 45, Issue 2, 2014, Pages 509-514

  Scheitz, Jan F ^a   Seiffge, David J ^b   Tütüncü, Serdar ^a   Gensicke, Henrik ^b   Audebert, Heinrich J ^a   Bonati, Leo H ^b   Fiebach, Jochen B ^a   Tränka, Christopher ^b   Lyrer, Philippe A ^b   Endres, Matthias ^a   Engelter, Stefan T ^b   Nolte, Christian H ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Hemorrhage; Hydroxymethylglutaryl CoA reductase inhibitors; Stroke; Thrombolytic therapy; Tissue plasminogen activator

Indexed keywords

ATORVASTATIN; CHOLESTEROL; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PRAVASTATIN; ROSUVASTATIN; SIMVASTATIN;

ADULT; AGED; BLOOD CLOT LYSIS; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CONFERENCE PAPER; DISEASE ASSOCIATION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; PRIORITY JOURNAL; RANKIN SCALE; RISK ASSESSMENT; TREATMENT OUTCOME; VERY ELDERLY;

HEMORRHAGE; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; STROKE; THROMBOLYTIC THERAPY; TISSUE PLASMINOGEN ACTIVATOR;

AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; CHOLESTEROL, LDL; COHORT STUDIES; DATA INTERPRETATION, STATISTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MIDDLE AGED; REGISTRIES; REGRESSION ANALYSIS; STROKE; THROMBOLYTIC THERAPY; TREATMENT OUTCOME;

EID: 84893640583     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.113.002751     Document Type: Conference Paper

References (31)

1. Amarenco P, Labreuche J. Lipid management in the prevention of stroke: review and updated meta-analysis of statins for stroke prevention. Lancet Neurol. 2009;8:453-463.
2. Violi F, Calvieri C, Ferro D, Pignatelli P. Statins as antithrombotic drugs. Circulation. 2013;127:251-257.
3. Ní Chróinín D, Asplund K, Åsberg S, Callaly E, Cuadrado-Godia E, Díez-Tejedor E, et al. Statin therapy and outcome after ischemic stroke: systematic review and meta-analysis of observational studies and randomized trials. Stroke. 2013;44:448-456.
4. Engelter ST, Soinne L, Ringleb P, Sarikaya H, Bordet R, Berrouschot J, et al. IV thrombolysis and statins. Neurology. 2011;77:888-895.
5. Meseguer E, Mazighi M, Lapergue B, Labreuche J, Sirimarco G, Gonzalez-Valcarcel J, et al. Outcomes after thrombolysis in AIS according to prior statin use: a registry and review. Neurology. 2012;79:1817-1823.
6. Martinez-Ramirez S, Delgado-Mederos R, Marín R, Suárez-Calvet M, Sáinz MP, Alejaldre A, et al. Statin pretreatment may increase the risk of symptomatic intracranial haemorrhage in thrombolysis for ischemic stroke: results from a case-control study and a meta-analysis. J Neurol. 2012;259:111-118.
7. Scheitz JF, Nolte CH, Endres M. Should statins be paused or discontinued after thrombolysis or acute intracerebral hemorrhage? No! Stroke. 2013;44:1472-1476.
8. Hacke W, Kaste M, Bluhmki E, Brozman M, Dávalos A, Guidetti D, et al; ECASS Investigators. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 2008;359:1317-1329.
9. Scheitz JF, Endres M, Heuschmann PU, Audebert HJ, Nolte CH. Reduced risk of poststroke pneumonia in thrombolyzed stroke patients with continued statin treatment. Int J Stroke. September 13, 2012. doi: 10.1111/j.1747-4949.2012. 00864.x.
10. Gensicke H, Seiffge DJ, Polasek AE, Peters N, Bonati LH, Lyrer PA, et al. Long-term outcome in stroke patients treated with IV thrombolysis. Neurology. 2013;80:919-925.
11. Nicholls SJ, Brandrup-Wognsen G, Palmer M, Barter PJ. Meta-analysis of comparative efficacy of increasing dose of Atorvastatin versus Rosuvastatin versus Simvastatin on lowering levels of atherogenic lipids (from VOYAGER). Am J Cardiol. 2010;105:69-76.
12. Law MR, Wald NJ, Rudnicka AR. Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis. BMJ. 2003;326:1423.
13. McTaggart F, Buckett L, Davidson R, Holdgate G, McCormick A, Schneck D, et al. Preclinical and clinical pharmacology of Rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Am J Cardiol. 2001;87(5A):28B-32B.
14. Molnar AO, Coca SG, Devereaux PJ, Jain AK, Kitchlu A, Luo J, et al. Statin use associates with a lower incidence of acute kidney injury after major elective surgery. J Am Soc Nephrol. 2011;22:939-946.
15. Dormuth CR, Hemmelgarn BR, Paterson JM, James MT, Teare GF, Raymond CB, et al; Canadian Network for Observational Drug Effect Studies. Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases. BMJ. 2013;346:f880.
16. Hacke W, Kaste M, Fieschi C, von Kummer R, Davalos A, Meier D, et al. Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators. Lancet. 1998;352:1245-1251.
17. Dennis M, Mead G, Doubal F, Graham C. Determining the modified Rankin score after stroke by postal and telephone questionnaires. Stroke. 2012;43:851-853.
18. Endres M. Statins and stroke. J Cereb Blood Flow Metab. 2005;25:1093-1110.
19. Asahi M, Huang Z, Thomas S, Yoshimura S, Sumii T, Mori T, et al. Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia. J Cereb Blood Flow Metab. 2005;25:722-729.
20. Georgiadis AL, Hussein HM, Vazquez G, Shah Q, Suri MF, Ezzeddine MA, et al. Premorbid use of statins is associated with higher recanalization rates in patients with acute ischemic stroke undergoing endovascular treatment. J Neuroimaging. 2009;19:19-22.
21. Ford AL, An H, D'Angelo G, Ponisio R, Bushard P, Vo KD, et al. Preexisting statin use is associated with greater reperfusion in hyperacute ischemic stroke. Stroke. 2011;42:1307-1313.
22. Martínez-Sánchez P, Fuentes B, Martínez- Martínez M, Ruiz-Ares G, Fernández-Travieso J, Sanz-Cuesta BE, et al. Treatment with statins and ischemic stroke severity: does the dose matter? Neurology. 2013;80:1800-1805.
23. O'Donnell MJ, Xavier D, Liu L, Zhang H, Chin SL, Rao-Melacini P, et al; INTERSTROKE Investigators. Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. Lancet. 2010;376:112-123.
24. Bang OY, Saver JL, Liebeskind DS, Starkman S, Villablanca P, Salamon N, et al. Cholesterol level and symptomatic hemorrhagic transformation after ischemic stroke thrombolysis. Neurology. 2007;68:737-742.
25. Nardi K, Engelter S, Strbian D, Sarikaya H, Arnold M, Casoni F, et al; Lipid Profile in Thrombolysis Study Group. Lipid profiles and outcome in patients treated by intravenous thrombolysis for cerebral ischemia. Neurology. 2012;79:1101-1108.
26. Biffi A, Devan WJ, Anderson CD, Cortellini L, Furie KL, Rosand J, et al. Statin treatment and functional outcome after ischemic stroke: case- control and meta-analysis. Stroke. 2011;42:1314-1319.
27. Alvarez-Sabín J, Huertas R, Quintana M, Rubiera M, Delgado P, Ribó M, et al. Prior statin use may be associated with improved stroke outcome after tissue plasminogen activator. Stroke. 2007;38:1076-1078.
28. Cappellari M, Bovi P, Moretto G, Zini A, Nencini P, Sessa M, et al. The THRombolysis and STatins (THRaST) study. Neurology. 2013;80:655-661.
29. Rocco A, Sykora M, Ringleb P, Diedler J. Impact of statin use and lipid profile on symptomatic intracerebral haemorrhage, outcome and mortality after intravenous thrombolysis in acute stroke. Cerebrovasc Dis. 2012;33:362-368.
30. Colivicchi F, Bassi A, Santini M, Caltagirone C. Discontinuation of statin therapy and clinical outcome after ischemic stroke. Stroke. 2007;38:2652-2657.
31. Singer OC, Humpich MC, Fiehler J, Albers GW, Lansberg MG, Kastrup A, et al; MR Stroke Study Group Investigators. Risk for symptomatic intracerebral hemorrhage after thrombolysis assessed by diffusion- weighted magnetic resonance imaging. Ann Neurol. 2008;63:52-60.