IV thrombolysis and statins

Neurology

Volumn 77, Issue 9, 2011, Pages 888-895

  Engelter, S T ^a   Soinne, L ^b   Ringleb, P ^c   Sarikaya, H ^d   Bordet, R ^e   Berrouschot, J ^f   Odier, C ^g   Arnold, M ^h   Ford, G A ⁱ   Pezzini, A ^j   Zini, A ^k   Rantanen, K ^b   Rocco, A ^c   Bonati, L H ^a   Kellert, L ^c   Strbian, D ^b   Stoll, A ^f   Meier, N ^h   Michel, P ^g   Baumgartner, R W ^d   Leys, D ^e   Tatlisumak, T ^b   Lyrer, P A ^a   more..

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^d UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^e UNIV LILLE   (France)

^f University Hospital Altenburg   (Germany)

^g LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^h UNIVERSITY OF BERN   (Switzerland)

ⁱ NEWCASTLE UNIVERSITY   (United Kingdom)

^j BRESCIA CIVIL HOSPITAL   (Italy)

^k Nuovo Ospedale S Agostino   (Italy)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; FIBRINOLYTIC AGENT; SIMVASTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

AGE; AGED; ARTICLE; BLOOD CLOT LYSIS; BLOOD PRESSURE; BRAIN HEMORRHAGE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE SEVERITY; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PRIORITY JOURNAL; SEX DIFFERENCE; STROKE; TREATMENT OUTCOME; CHEMICALLY INDUCED DISORDER; CLINICAL TRIAL; COMPARATIVE STUDY; FIBRINOLYTIC THERAPY; INTRAVENOUS DRUG ADMINISTRATION; METHODOLOGY; MIDDLE AGED; MULTICENTER STUDY; PROSPECTIVE STUDY;

AGED; AGED, 80 AND OVER; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INFUSIONS, INTRAVENOUS; INTRACRANIAL HEMORRHAGES; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; STROKE; THROMBOLYTIC THERAPY; TREATMENT OUTCOME;

EID: 80055098598     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e31822c9135     Document Type: Article

References (26)

1. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995;333: 1581-1587.
2. Vaughan CJ, Delanty N. Neuroprotective properties of statins in cerebral ischemia and stroke. Stroke 1999;30: 1969-1973. (Pubitemid 29411843)
3. Pezzini A, Del Zotto E, Volonghi I, Giossi A, Costa P, Padovani A. New insights into the pleiotropic effects of statins for stroke prevention. Mini Rev Med Chem 2009; 9:794-804.
4. Goldstein LB, Amarenco P, Zivin J, et al. Statin treatment and stroke outcome in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial. Stroke 2009;40:3526-3531.
5. Deplanque D, Masse I, Lefebvre C, Libersa C, Leys D, Bordet R. Prior TIA, lipid-lowering drug use, and physical activity decrease ischemic stroke severity. Neurology 2006; 67:1403-1410. (Pubitemid 44632064)
6. Arboix A, Garcia-Eroles L, Oliveres M, Targa C, Balcells M, Massons J. Pretreatment with statins improves early outcome in patients with first-ever ischaemic stroke: a pleiotropic effect of statins or a beneficial effect of hypercholesterolemia? BMC Neurol 2010;10:47.
7. Asahi M, Huang Z, Thomas S, et al. Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia. J Cereb Blood Flow Metab 2005;25:722-729. (Pubitemid 40705607)
8. Goldstein LB, Amarenco P, Szarek M, et al. Hemorrhagic stroke in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels study. Neurology 2008; 70:2364-2370.
9. Alvarez-Sabin J, Huertas R, Quintana M, et al. Prior statin use may be associated with improved stroke outcome after tissue plasminogen activator. Stroke 2007; 38:1076-1078. (Pubitemid 46568478)
10. Faivre A, Sagui E, Canini F, et al. Intravenous thrombolysis with rt-PA in stroke: Experience of the French military hospital of Toulon from September 2003 to June 2009. Rev Neurol 2010;166:909-920.
11. Meier N, Nedeltchev K, Brekenfeld C, et al. Prior statin use, intracranial hemorrhage, and outcome after intraarterial thrombolysis for acute ischemic stroke. Stroke 2009;40:1729-1737.
12. Miedema I, Uyttenboogaart M, Koopman K, De KJ, Luijckx GJ. Statin use and functional outcome after tissue plasminogen activator treatment in acute ischaemic stroke. Cerebrovasc Dis 2010;29:263-267.
13. Makihara N, Okada Y, Koga M, et al. Effects of statin use on intracranial hemorrhage and clinical outcome after intravenous rt-PA for acute ischemic stroke: SAMURAI rt-PA registry. Rinsho Shinkeigaku 2010;50:225-231.
14. Engelter ST, Rutgers MP, Hatz F, et al. Intravenous thrombolysis in stroke attributable to cervical artery dissection. Stroke 2009;40:3772-3776.
15. Lyden P, Brott T, Tilley B, et al. Improved reliability of the NIH Stroke Scale using video training. Stroke 1994; 25:2220-2226. (Pubitemid 24338379)
16. Adams HPJ, Bendixen BH, Kappelle LJ, et al. Classification of subtype of acute ischemic stroke: definitions for use in a multicenter clinical trial: TOAST: Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993;24:35-41. (Pubitemid 23014379)
17. Fluri F, Hatz F, Voss B, Lyrer PA, Engelter ST. Restenosis after carotid endarterectomy: significance of newly acquired risk factors. Eur J Neurol 2010;17:493-498.
18. Koenig MA, Grega MA, Bailey MM, et al. Statin use and neurologic morbidity after coronary artery bypass grafting: a cohort study. Neurology 2009;73:2099-2106.
19. Hacke W, Kaste M, Fieschi C, et al. Randomised doubleblind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Lancet 1998;352:1245-1251. (Pubitemid 28470336)
20. Kent DM, Selker HP, Ruthazer R, Bluhmki E, Hacke W. The stroke-thrombolytic predictive instrument: a predictive instrument for intravenous thrombolysis in acute ischemic stroke. Stroke 2006;37:2957-2962. (Pubitemid 44900816)
21. Demchuk AM, Tanne D, Hill MD, et al. Predictors of good outcome after intravenous tPA for acute ischemic stroke. Neurology 2001;57:474-480. (Pubitemid 32757596)
22. Derex L, Nighoghossian N. Intracerebral haemorrhage after thrombolysis for acute ischaemic stroke: an update. J Neurol Neurosurg Psychiatry 2008;79:1093-1099.
23. Diedler J, Ahmed N, Sykora M, et al. Safety of intravenous thrombolysis for acute ischemic stroke in patients receiving antiplatelet therapy at stroke onset. Stroke 2010;41:288-294.
24. Shuaib A, Lees KR, Lyden P, et al, the SAINT II Trial Investigators. NXY-059 for the treatment of acute ischemic stroke. N Engl J Med 2007;357:562-571. (Pubitemid 47236281)
25. Rha JH, Saver JL. The impact of recanalization on ischemic stroke outcome: a meta-analysis. Stroke 2007;38:967-973. (Pubitemid 46568460)
26. Bang OY, Saver JL, Liebeskind DS, et al. Cholesterol level and symptomatic hemorrhagic transformation after ischemic stroke thrombolysis. Neurology 2007;68:737-742. (Pubitemid 46667898)