Development of urinary biomarkers for internal exposure by cesium-137 using a metabolomics approach in mice

Radiation Research

Volumn 181, Issue 1, 2014, Pages 54-64

  Goudarzi, Maryam ^a   Weber, Waylon ^b   Mak, Tytus D ^a   Chung, Juijung ^a   Doyle Eisele, Melanie ^b   Melo, Dunstana ^b   Brenner, David J ^c   Guilmette, Raymond A ^b   Fornace, Albert J ^a  

^a GEORGETOWN UNIVERSITY   (United States)

^b LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^c Georgetown University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; AMINO ACID; CESIUM 137; CITRIC ACID; GLYCINE; HEXANOYLGLYCINE; HIPPURIC ACID; ISETHIONIC ACID; ISOVALERYLGLYCINE; N ACETYLSPERMIDINE; SPERMIDINE; TAURINE; TIGLYLGLYCINE; UNCLASSIFIED DRUG; URIC ACID; XANTHURENIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CITRIC ACID CYCLE; CONTROLLED STUDY; FATTY ACID METABOLISM; GAMMA RADIATION; MALE; METABOLITE; METABOLOMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINALYSIS; URINARY EXCRETION;

ANIMALS; BIOLOGICAL MARKERS; CESIUM RADIOISOTOPES; HUMANS; MALE; METABOLOMICS; MICE; MICE, INBRED C57BL;

EID: 84893637515     PISSN: 00337587     EISSN: 19385404     Source Type: Journal    
DOI: 10.1667/RR13479.1     Document Type: Article

References (23)

1. Fushiki S. Radiation hazards in children-Lessons from Chernobyl, Three-mile island and Fukushima. Brain Development 2013; 35:220-227.
2. Boecker BB. Comparison of 137Cs metabolism in the beagle dog following inhalation and intravenous injection. Health Phys 1969; 16:785-788.
3. Stabin MG, Peterson TE, Holburn GE, Emmons MA. Voxel-based mouse and rat models for internal dose calculations. J Nucl Med 2006; 47:655-659.
4. Miller G, Bertelli L, Klare K, Weber W, Doyle-Eisele M, Guilmette R. Software for empirical building of biokinetic models for normal and decorporation-affected data. Health Phys 2012; 103:484-494.
5. Laiakis EC, Hyduke DR, Fornace Jr AJ. Comparison of mouse urinary metabolomics profiles after exposure to the inflammatory stressors gamma radiation and lipopolysaccharide. Radiat Res 2012; 177:187-199.
6. Kanehisa M, Goto S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res 2000; 28:27-30.
7. Zuniga A, Li L. Ultra-high performance liquid chromatography tandem mass spectrometry for comprehensive analysis of urinary acylcarnitines. Anal Chimica Acta 2011; 689:77-84.
8. Chase DH, Hillman SL, Van Hove JLK, Naylor EW. Rapid diagnosis of MCAD deficiency: quantitative analysis of octanoylcarnitine and other acylcarnitines in newborn blood spots by tandem mass spectrometry. Clinical Chem 1997; 43:2106-2113.
9. Millington DS, Roe CR, Maltby DA. Characterization of new diagnostic acylcarnitines in patients with beta-ketothiolase deficiency and glutaric aciduria type I using mass spectrometry. Biomed Environ Mass Spectrom 1987; 14:711-716.
10. Johnson CH, Patterson A, Krausz KW, Lanz C, Kang DW, Luecke H, et al. Radiation metabolomics 4. UPLC-ESI-QTOFMS-based metabolomics for urinary biomarker discovery in gamma-irradiated rats. Radiat Res 2011; 175:473-484.
11. Tyburski JB, Patterson AD, Krausz KW, Slavik J, Fornace AJ, Jr, Gonzalez FJ, et al. Radiation metabolomics 1. Identification of minimally invasive urine biomarkers for gamma-radiation exposure in mice. Radiat Res 2008; 170:1-14.
12. Malina HZ, Richter C, Mehl M, Hess OM. Pathological apoptosis by xanthurenic acid, a tryptophan metabolite: activation of cell caspases but not cytoskeleton breakdown. BMC Physiology 2001; 1:7.
13. Dilley J. The origin of urinary taurine excretion during chronic radiation injury. Radiat Res 1972; 50:191-196.
14. Fellman J, Roth E, Avedovech N, McCarthy K. The metabolism of taurine to isethionate. Arch Biochem Biophys 1980; 204:560-567.
15. Huxtable R, Bressler R. Taurine and isethionic acid: distribution and interconversion in the rat. Nature 1972; 102:805-814.
16. Phipps A, Stewart J, Wright B, Wilson I. Effect of diet on the urinary excretion of hippuric acid and other dietary-derived aromatics in rat A complex interaction between diet, gut microflora and substrate specificity. Xenobiotica 1998; 28:527-537.
17. Boulange CL, Claus SP, Chou CJ, et al. Early metabolic adaptation in C57BL/6 mice resistant to high fat diet induced weight gain involves and activation of mitochondrial oxidative pathways. J Proteome Res 2013; 12:1956-1968.
18. Barjaktarovic Z, Shyla A, Azimzadeh O, Schulz S, Haagen J, Dorr W, et al. Ionizing radiation induces persistent alterations in the cardiac mitochondrial function of C57BL/6 mice 40weeks after local heart exposure. Radiother Oncol 2013; 106:404-410.
19. Fukao T, Zhang GX, Sakura N, Kubo T, Yamaga H, Hazama A, et al. The mitochondrial acetoacetyl-CoA thiolase (T2) deficiency in Japanese patients: urinary organic acid and blood acylcarnitine profiles under stable conditions have subtle abnormalities in T2-deficient patients with some residual T2 activity. J Inherit Metab Dis 2003; 26:423-431.
20. Tyburski JB, Patterson AD, Krausz KW, Slavik J, Fornace Jr AJ, Gonzalez FJ, et al. Radiation metabolomics 2 dose-and timedependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice. Radiat Res 2009; 172:42-57.
21. Amundson SA, Do KT, Fornace Jr AJ. Induction of stress genes by low doses of gamma rays. Radiat Res 1999; 152: 225-231.
22. Amundson SA, Bittner ML, Fornace Jr AJ. Functional genomics as a window on radiation stress signaling. Oncogene 2003; 22: 5828-5833.
23. Amundson SA, Lee A, Koch-Paiz C, Bittner ML, Meltzer P, Trent JM, et al. Differential responses of stress genes to low dose-rate gamma-irradiation. Mol Cancer Res 2003; 1:445-452.