Mucosal delivery of antigen-coated nanoparticles to lungs confers protective immunity against tuberculosis infection in mice

European Journal of Immunology

Volumn 44, Issue 2, 2014, Pages 440-449

  Stylianou, Elena ^a,b   Diogo, Gil R ^a   Pepponi, Ilaria ^a,b   van Dolleweerd, Craig ^a   Arias, Mauricio A ^a   Locht, Camille ^c,d,e   Rider, Christopher C ^f   Sibley, Laura ^f   Cutting, Simon M ^f   Loxley, Andrew ^g   Ma, Julian K C ^a   Reljic, Rajko ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c INSTITUT PASTEUR DE LILLE   (France)

^d INSERM U1019   (France)

^e UNIV LILLE   (France)

^f UNIVERSITY OF LONDON   (United Kingdom)

^g Particle Sciences Inc   (United States)

Author keywords

Immunity; Mucosal; Nanoparticles; Tuberculosis; Vaccine

Indexed keywords

ANTIGEN COATED NANOPARTICLE; BCG VACCINE; GAMMA INTERFERON; HEPARIN BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; MYCOBACTERIUM ANTIGEN; NANOPARTICLE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIAL LOAD; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; COLONY FORMING UNIT; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; FEMALE; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNITY; IMMUNIZATION; IMMUNOGENICITY; IN VITRO STUDY; INTERFERON PRODUCTION; LUNG LAVAGE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN BINDING; SPLEEN; SPLEEN CELL; T LYMPHOCYTE; TUBERCULOSIS; WESTERN BLOTTING;

ACYLTRANSFERASES; ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL LOAD; BACTERIAL PROTEINS; BCG VACCINE; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; EPITHELIAL CELLS; FEMALE; INTERFERON-GAMMA; INTERLEUKIN-2; LECTINS; MICE; MICE, INBRED BALB C; MYCOBACTERIUM TUBERCULOSIS; NANOPARTICLES; PULMONARY ALVEOLI; RECOMBINANT PROTEINS; RESPIRATORY MUCOSA; TUBERCULOSIS; TUBERCULOSIS VACCINES; TUMOR NECROSIS FACTOR-ALPHA; VACCINES, SUBUNIT;

EID: 84893626091     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201343887     Document Type: Article

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