Gimap and T cells: A matter of life or death

European Journal of Immunology

Volumn 44, Issue 2, 2014, Pages 348-351

  Ciucci, Thomas ^a   Bosselut, Rémy ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Auto immunity; Bcl 2; GTPase immune associated proteins; Lymphopenia; T cell survival

Indexed keywords

CARRIER PROTEINS AND BINDING PROTEINS; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATASE IMMUNE ASSOCIATED PROTEIN; GUANOSINE TRIPHOSPHATASE IMMUNE ASSOCIATED PROTEIN 3; GUANOSINE TRIPHOSPHATASE IMMUNE ASSOCIATED PROTEIN 5; PROTEIN BCL 2; PROTEIN BCL XL; UNCLASSIFIED DRUG;

ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CELL MUTANT; CELL SURVIVAL; CELLULAR IMMUNITY; DISEASE SEVERITY; EXTRAMEDULLARY HEMATOPOIESIS; HOMEOSTASIS; HUMAN; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; INFLAMMATORY DISEASE; LYMPHOCYTOPENIA; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE;

AUTO-IMMUNITY; BCL-2; GTPASE IMMUNE-ASSOCIATED PROTEINS; LYMPHOPENIA; T-CELL SURVIVAL;

ANIMALS; AUTOIMMUNE DISEASES; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEINS; HUMANS; INFLAMMATION; LYMPHOCYTES; T-LYMPHOCYTES;

EID: 84893591321     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201344375     Document Type: Article

References (26)

1. Yano, K., Carter, C., Yoshida, H., Abe, T., Yamada, H., Nitta, T., Ishimaru, N. et al., Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse. Eur. J. immunol. 2014. 44: 561-572.
2. Nitta, T. and Takahama, Y., The lymphocyte guard-IANs: regulation of lymphocyte survival by IAN/GIMAP family proteins. Trends Immunol. 2007. 28: 58-65.
3. Krucken, J., Schroetel, R. M., Muller, I. U., Saidani, N., Marinovski, P., Benten, W. P., Stamm, O. et al., Comparative analysis of the human gimap gene cluster encoding a novel GTPase family. Gene 2004. 341: 291-304.
4. Nitta, T., Nasreen, M., Seike, T., Goji, A., Ohigashi, I., Miyazaki, T., Ohta, T. et al., IAN family critically regulates survival and development of T lymphocytes. PLoS Biol. 2006. 4: e103.
5. Wang, Z. and Li, X., IAN/GIMAPs are conserved and novel regulators in vertebrates and angiosperm plants. Plant Signal. Behav. 2009. 4: 165-167.
6. Filen, S. and Lahesmaa, R., GIMAP proteins in T-lymphocytes. J. Signal. Transduct. 2010. 2010: 268589.
7. Schulteis, R. D., Chu, H., Dai, X., Chen, Y., Edwards, B., Haribhai, D., Williams, C. B. et al., Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5. Blood 2008. 112: 4905-4914.
8. Barnes, M. J., Aksoylar, H., Krebs, P., Bourdeau, T., Arnold, C. N., Xia, Y., Khovananth, K. et al., Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice. J. Immunol. 2010. 184: 3743-3754.
9. Saunders, A., Webb, L. M., Janas, M. L., Hutchings, A., Pascall, J., Carter, C., Pugh, N. et al., Putative GTPase GIMAP1 is critical for the development of mature B and T lymphocytes. Blood 2010. 115: 3249-3257.
10. Chen, Y., Yu, M., Dai, X., Zogg, M., Wen, R., Weiler, H. and Wang, D., Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells. J. Exp. Med. 2011. 208: 923-935.
11. MacMurray, A. J., Moralejo, D. H., Kwitek, A. E., Rutledge, E. A., Van Yserloo, B., Gohlke, P., Speros, S. J. et al., Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene. Genome Res. 2002. 12: 1029-1039.
12. Hornum, L., Romer, J. and Markholst, H., The diabetes-prone BB rat carries a frameshift mutation in Ian4, a positional candidate of Iddm1. Diabetes 2002. 51: 1972-1979.
13. Lang, J. A., Kominski, D., Bellgrau, D. and Scheinman, R. I., Partial activation precedes apoptotic death in T cells harboring an IAN gene mutation. Eur. J. Immunol. 2004. 34: 2396-2406.
14. Boyman, O., Krieg, C., Homann, D. and Sprent, J., Homeostatic maintenance of T cells and natural killer cells. Cell Mol. Life Sci. 2012. 69: 1597-1608.
15. Kimura, M. Y., Pobezinsky, L. A., Guinter, T. I., Thomas, J., Adams, A., Park, J. H., Tai, X. et al., IL-7 signaling must be intermittent, not continuous, during CD8(+) T cell homeostasis to promote cell survival instead of cell death. Nat. Immunol. 2013. 14: 143-151.
16. Renault, T. T. and Chipuk, J. E., Getting away with murder: how does the BCL-2 family of proteins kill with immunity? Ann. NY Acad. Sci. 2013. 1285: 59-79.
17. Daheron, L., Zenz, T., Siracusa, L. D., Brenner, C. and Calabretta, B., Molecular cloning of Ian4: a BCR/ABL-induced gene that encodes an outer membrane mitochondrial protein with GTP-binding activity. Nucleic Acids Res. 2001. 29: 1308-1316.
18. Sandal, T., Aumo, L., Hedin, L., Gjertsen, B. T. and Doskeland, S. O., Irod/Ian5: an inhibitor of gamma-radiation- and okadaic acid-induced apoptosis. Mol. Biol. Cell 2003. 14: 3292-3304.
19. Schwefel, D., Frohlich, C., Eichhorst, J., Wiesner, B., Behlke, J., Aravind, L. and Daumke, O., Structural basis of oligomerization in septin-like GTPase of immunity-associated protein 2 (GIMAP2). Proc. Natl. Acad. Sci. USA 2010. 107: 20299-20304.
20. Schwefel, D., Arasu, B. S., Marino, S. F., Lamprecht, B., Kochert, K., Rosenbaum, E., Eichhorst, J. et al., Structural insights into the mechanism of GTPase activation in the GIMAP family. Structure 2013. 21: 550-559.
21. Aksoylar, H. I., Lampe, K., Barnes, M. J., Plas, D. R. and Hoebe, K., Loss of immunological tolerance in Gimap5-deficient mice is associated with loss of Foxo in CD4+ T cells. J. Immunol. 2012. 188: 146-154.
22. Jacob, H. J., Pettersson, A., Wilson, D., Mao, Y., Lernmark, A. and Lander, E. S., Genetic dissection of autoimmune type I diabetes in the BB rat. Nat. Genet. 1992. 2: 56-60.
23. Jokinen, R., Junnila, H. and Battersby, B. J., Gimap3: a foot-in-the-door to tissue-specific regulation of mitochondrial DNA genetics. Small GTPases 2011. 2: 31-35.
24. Saunders, A., Lamb, T., Pascall, J., Hutchings, A., Dion, C., Carter, C., Hepburn, L. et al., Expression of GIMAP1, a GTPase of the immunity-associated protein family, is not up-regulated in malaria. Malar. J. 2009. 8: 53.
25. Lim, M. K., Sheen, D. H., Kim, S. A., Won, S. K., Lee, S. S., Chae, S. C., Chung, H. T. et al., IAN5 polymorphisms are associated with systemic lupus erythematosus. Lupus 2009. 18: 1045-1052.
26. Jokinen, R., Marttinen, P., Sandell, H. K., Manninen, T., Teerenhovi, H., Wai, T., Teoli, D. et al., Gimap3 regulates tissue-specific mitochondrial DNA segregation. PLoS Genet. 2010. 6: e1001161.