Characterization of antigen-specific B cells using nominal antigen-coated flow-beads

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Degauque, Nicolas ^a,b,c   Ngono, Annie Elong ^a,b,c   Akl, Ahmed ^a,b,c   Lepetit, Maud ^a,b,c   Crochette, Romain ^a,b,c   Giral, Magali ^a,b,c   Lepourry, Julie ^a,b,c   Pallier, Annaick ^a,b,c   Castagnet, Stéphanie ^a,b,c   Dugast, Emilie ^a,b,c   Guillot Gueguen, Cécile ^b   Jacq Foucher, Marylène ^d   Saulquin, Xavier ^c,e   Cesbron, Anne ^f   Laplaud, David ^a,b,c,d   Nicot, Arnaud ^a,b,c   Brouard, Sophie ^a,b,c   Soulillou, Jean Paul ^a,b,c  

^a UMR 1064   (France)

^b NANTES UNIVERSITY HOSPITAL   (France)

^c UNIVERSITÉ DE NANTES   (France)

^d INSERM   (France)

^e Equipe 10 Labellisée Ligue Nationale Contre le Cancer 2008   (France)

^f ETABLISSEMENT FRANÇAIS DU SANG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ANIMALS; ANTIGENS; ANTIGENS, CD19; AUTOANTIGENS; B-LYMPHOCYTES; FEMALE; FLOW CYTOMETRY; FLUORESCENT DYES; HLA ANTIGENS; HUMANS; IMMUNIZATION; KIDNEY TRANSPLANTATION; MALE; MICE; MICROSPHERES; MIDDLE AGED; POLYMERS; VACCINES; VIRAL PROTEINS; YOUNG ADULT;

EID: 84893570512     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0084273     Document Type: Article

References (34)

1. Hawker K, O'Connor P, Freedman MS, Calabresi PA, Antel J, et al. (2009) Rituximab in patients with primary progressive multiple sclerosis: Results of a randomized double-blind placebo-controlled multicenter trial. Ann Neurol 66: 460-471. doi:10.1002/ana.21867.
2. Brulhart L, Ciurea A, Finckh A, Notter A, Waldburger JM, et al. (2006) Efficacy of B cell depletion in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor agents: an open-label observational study. Annals of the Rheumatic Diseases 65: 1255-1257. doi:10.1136/ard.2005.051169. (Pubitemid 44277415)
3. Iwata Y, Matsushita T, Horikawa M, DiLillo DJ, Yanaba K, et al. (2011) Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. Blood 117: 530-541. doi:10.1182/blood- 2010-07-294249.
4. Yanaba K, Bouaziz JD, Matsushita T, Tsubata T, Tedder TF (2009) The Development and Function of Regulatory B Cells Expressing IL-10 (B10 Cells) Requires Antigen Receptor Diversity and TLR Signals. The Journal of Immunology 182: 7459-7472. doi:10.4049/jimmunol.0900270.
5. Frommer F, Heinen TJAJ, Wunderlich FT, Yogev N, Buch T, et al. (2008) Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion. The Journal of Immunology 181: 5748-5759.
6. Olkhanud PB, Damdinsuren B, Bodogai M, Gress RE, Sen R, et al. (2011) Tumor-Evoked Regulatory B Cells Promote Breast Cancer Metastasis by Converting Resting CD4 + T Cells to T-Regulatory Cells. Cancer Research 71: 3505-3515. doi:10.1158/0008-5472.CAN-10-4316.
7. Hagn M, Schwesinger E, Ebel V, Sontheimer K, Maier J, et al. (2009) Human B Cells Secrete Granzyme B When Recognizing Viral Antigens in the Context of the Acute Phase Cytokine IL-21. The Journal of Immunology 183: 1838-1845. doi:10.4049/jimmunol.0901066.
8. Hagn M, Ebel V, Sontheimer K, Schwesinger E, Lunov O, et al. (2010) CD5+ B cells from individuals with systemic lupus erythematosus express granzyme B. Eur J Immunol 40: 2060-2069. doi:10.1002/eji.200940113.
9. Lang J, Arnold B, Hammerling G, Harris AW, Korsmeyer S, et al. (1997) Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells. J Exp Med 186: 1513-1522. (Pubitemid 27479811)
10. Halverson R, Torres RM, Pelanda R (2004) Receptor editing is the main mechanism of B cell tolerance toward membrane antigens. Nat Immunol 5: 645-650. doi:10.1038/ni1076. (Pubitemid 38811890)
11. Wardemann H (2003) Predominant Autoantibody Production by Early Human B Cell Precursors. Science 301: 1374-1377. doi:10.1126/science.1086907.
12. Zikherman J, Parameswaran R, Weiss A (2013) Endogenous antigen tunes the responsiveness of naive B cells but not T cells. Nature 489: 160-164. doi:10.1038/nature11311.
13. Rudolphi U, Hohlbaum A, Lang B, Peter HH, Melchers I (1993) The B cell repertoire of patients with rheumatoid arthritis. Frequencies and specificities of peripheral blood B cells reacting with human IgG, human collagens, a mycobacterial heat shock protein and other antigens. Clinical & Experimental Immunology 92: 404-411. (Pubitemid 23183747)
14. Taylor JJ, Martinez RJ, Titcombe PJ, Barsness LO, Thomas SR, et al. (2012) Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen. Journal of Experimental Medicine 209: 2065-2077. doi:10.1084/jem.20112272.
15. Litzenburger T, Fässler R, Bauer J, Lassmann H, Linington C, et al. (1998) B lymphocytes producing demyelinating autoantibodies: development and function in gene-targeted transgenic mice. J Exp Med 188: 169-180. (Pubitemid 28328615)
16. Berthelot L, Laplaud DA, Pettré S, Ballet C, Michel L, et al. (2008) Blood CD8+T cell responses against myelin determinants in multiple sclerosis and healthy individuals. Eur J Immunol 38: 1889-1899. doi:10.1002/eji.200838023.
17. Elong Ngono A, Pettré S, Salou M, Bahbouhi B, Soulillou J-P, et al. (2012) Frequency of circulating autoreactive T cells committed to myelin determinants in relapsing-remitting multiple sclerosis patients. Clinical Immunology 144: 117-126. doi:10.1016/j.clim.2012.05.009.
18. Sis B, Mengel M, Haas M, Colvin RB, Halloran PF, et al. (2010) Banff '09 Meeting Report: Antibody Mediated Graft Deterioration and Implementation of Banff Working Groups. Am J Transplant 10: 464-471. doi:10.1111/j.1600-6143.2009. 02987.x.
19. Pollinger B, Krishnamoorthy G, Berer K, Lassmann H, Bosl MR, et al. (2009) Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells. Journal of Experimental Medicine 206: 1303-1316. doi:10.1006/meth.2001.1261.
20. Bodinier M, Peyrat MA, Tournay C, Davodeau F, Romagne F, et al. (2000) Efficient detection and immunomagnetic sorting of specific T cells using multimers of MHC class I and peptide with reduced CD8 binding. Nat Med 6:707-710. doi:10.1038/76292. (Pubitemid 30398798)
21. Pei R, Lee J-H, Shih N-J, Chen M, Terasaki PI (2003) Single human leukocyte antigen flow cytometry beads for accurate identification of human leukocyte antigen antibody specificities. Transplantation 75: 43-49. doi:10.1097/01.TP.0000040431.80510.98. (Pubitemid 36139693)
22. Terasaki PI, Ozawa M, Castro R (2007) Four-year follow-up of a prospective trial of HLA and MICA antibodies on kidney graft survival. Am J Transplant 7: 408-415. doi:10.1111/j.1600-6143.2006.01644.x. (Pubitemid 46096334)
23. Damoiseaux J, Vaessen M, Knapen Y, Csernok E, Stegeman CA, et al. (2007) Evaluation of the FIDIS Vasculitis Multiplex Immunoassay for Diagnosis and Follow-up of ANCA-Associated Vasculitis and Goodpasture's Disease. Annals of the New York Academy of Sciences 1109: 454-463. doi:10.1196/annals. 1398.051.
24. Meffre E, Casellas R, Nussenzweig MC (2000) Antibody regulation of B cell development. Nat Immunol 1: 379-385. doi:10.1038/80816.
25. Bahbouhi B, Berthelot L, Pettre S, Michel L, Wiertlewski S, et al. (2009) Peripheral blood CD4+ T lymphocytes from multiple sclerosis patients are characterized by higher PSGL-1 expression and transmigration capacity across a human blood-brain barrier-derived endothelial cell line. Journal of Leukocyte Biology 86: 1049-1063. doi:10.1189/jlb.1008666.
26. Pascual V, Liu YJ, Magalski A, de Bouteiller O, Banchereau J, et al. (1994) Analysis of somatic mutation in five B cell subsets of human tonsil. J Exp Med 180: 329-339. (Pubitemid 24181081)
27. Carsetti R, Rosado MM, Wardmann H (2004) Peripheral development of B cells in mouse and man. Immunol Rev 197: 179-191. (Pubitemid 38142176)
28. Klinman D (2008) ELISPOT assay to detect cytokine-secreting murine and human cells. Curr Protoc Immunol Chapter 6: Unit6.19. doi:10.1002/0471142735. im0619s83.
29. Bromage E, Stephens R, Hassoun L (2009) The third dimension of ELISPOTs: Quantifying antibody secretion from individual plasma cells. Journal of Immunological Methods 346: 75-79. doi:10.1016/j.jim.2009.05.005.
30. Lycke NY, Coico R (2001) Measurement of immunoglobulin synthesis using the ELISPOT assay. Curr Protoc Immunol Chapter 7: Unit7.14. doi:10.1002/ 0471142735.im0714s17.
31. Zarkhin V, Kambham N, Li L, Kwok S, Hsieh S-C, et al. (2008) Characterization of intra-graft B cells during renal allograft rejection. Kidney International 74: 664-673. doi:10.1038/ki.2008.249.
32. Hippen BE, DeMattos A, Cook WJ, Kew CE, Gaston RS (2005) Association of CD20+ infiltrates with poorer clinical outcomes in acute cellular rejection of renal allografts. Am J Transplant 5: 2248-2252. doi:10.1111/j.1600-6143.2005. 01009.x. (Pubitemid 41648473)
33. Hwang HS, Song JH, Hyoung BJ, Lee SY, Jeon YJ, et al. (2010) Clinical impacts of CD38 + B cells on acute cellular rejection with CD20+ B cells in renal allograft. Transplantation 89: 1489-1495. doi:10.1097/TP.0b013e3181dd35b8.
34. Amanna IJ, Slifka MK (2010) Mechanisms that determine plasma cell lifespan and the duration of humoral immunity. Immunol Rev 236: 125-138. doi:10.1111/j.1600-065X.2010.00912.x.