Health hazards of xylene: A literature review

Journal of Clinical and Diagnostic Research

Volumn 8, Issue 2, 2014, Pages 271-274

  Rajan, Sharada T ^a   Malathi, N ^a  

^a SRI RAMACHANDRA UNIVERSITY   (India)

Author keywords

Biological exposure index; Laboratory technicians and Xylene toxicity; Methyl hippuric acid; Occupational safety

Indexed keywords

IPECAC; XYLENE;

ANOREXIA; BLEEDING; COMA; DIZZINESS; DRY SKIN; DYSPNEA; ERYTHEMA; EXPOSURE; EYE IRRITATION; FLUSHING; GASTROINTESTINAL SYMPTOM; HEALTH HAZARD; HEART PALPITATION; HEMODIALYSIS; HEMOPERFUSION; INTRA ALVEOLAR HAEMORRHAGE; LUNG CONGESTION; LUNG EDEMA; MUSCLE STRENGTH; NAUSEA; NEUROLOGIC DISEASE; NOSE IRRITATION; OCCUPATIONAL EXPOSURE; REVIEW; SPONTANEOUS ABORTION; THORAX PAIN; THROAT IRRITATION; URTICARIA; VASODILATATION; VOMITING;

EID: 84893568463     PISSN: 2249782X     EISSN: 0973709X     Source Type: Journal    
DOI: 10.7860/JCDR/2014/7544.4079     Document Type: Review

References (38)

1. Toxicological profile for Xylene, U. S department of Health and Human Services, Public Health Service, Agency for Toxic Substance and Disease Registry, August 1995.
2. Jacobson GA and McLean S. Biological monitoring of low level occupational xylene exposure and the role of recent exposure. Ann. Occup. Hyg. 2003; 47 (4): 331-36.
3. Riihimaki V and Savolainen K. Human exposure to m-xylene: Kinetics and acute effects on the central nervous system. Ann Occup Hyg. 1980; 23:411-22.
4. John.D. Bancroft and Marilyn Gamble. Theory and practice of Histological Techniques, fifth edition, Churchill Livingstone, 2006.
5. Mao IF, Chang FK and Chen ML. Delayed and competitively inhibited excretion of urinary hippuric acid in field workers co-exposed to toluene, ethyl benzene and xylene. Arch Env Contam Toxicology. 2007; 53: 678-83.
6. Matsui H, Kasao M and Imamura S. J. Chromatography. 1978; 145: 231-36.
7. Sabatini L, Barbieri A, Indiveri P, Mattioli S and Violante FS. Validation of an HPLC-MS/MS for the simultaneous determination of phenylmercapturic acid, benzylmercapturic acid and o-methylbenzyl mercapturic acid in urine as biomarkers of exposure to benzene, toluene and xylenes. J. Chromatography B. 2008; 863: 115-22.
8. Kandyala R, Raghavendra SDC, Rajasekharan ST. J Oral Maxillofac Pathol. 2010; Jan-Jun; 14(1): 1-5.
9. Nelson KW, Ege JF Jr and Ross M. Sensory response to certain industrial solvent vapors. J Ind Hyg Toxicol. 1943; 25:282-85.
10. Morley R, Eccleston DW and Douglas CP. Xylene poisoning: A report on one fatal case and two cases of recovery after prolonged unconsciousness. Br Med J. 1970; 3:442-43.
11. Uchida Y, Nakatsuka H and Ukai H. Symptoms and signs in workers exposed predominantly to xylenes. Int Arch Occup Environ Health. 1993; 64:597-605.
12. Hipolito RN. Xylene poisoning in laboratory workers: Case reports and discussion. Lab Med. 1980; 11593-595.
13. Taskinen H, Anttila A and Lindbohm ML. Spontaneous abortions and congenital malformations among the wives of men occupationally exposed to organic solvents. Scand J Work Environ Health. 1989; 15:345-52.
14. Abu Al Ragheb S, Salhab AS and Amr SS. Suicide by xylene ingestion: A case report and review of literature. Am J Forensic Med Pathol. 1986; 7:327-29.
15. Condie LW, Hill JR and Borzelleca JF. Oral toxicology studies with xylene isomers and mixed xylenes. Drug Chem Toxicol. 1988; 11:329-54.
16. Engstrom K, Husman K and Riihimaki V. Percutaneous absorption of m-xylene in man. Int. Arch. Occup. Environ. Health.1977; 39:181-89.
17. Riihimaki V and Pfaffli P. Percutaneous absorption of solvent vapors in man. Scand J Work Environ Health. 1978;(4):73-85
18. Palmer KT and Rycroft RJG. Occupational airborne contact urticaria due to xylene. Contact Dermatitis. 1993; 28:44.
19. Hine CH and Zuidema HH. The toxicological properties of hydrocarbon solvents. Ind Medicine. 1970; 39:39-44.
20. Silverman DM and Schatz RA. Pulmonary microsomal alterations following shortterm low-level inhalation of para-xylene in rats. Toxicology. 1991; 65:271-281.
21. EPA. Drinking water criteria document for xylenes. 1985. Cincinnati, OH: U.S. Environmental Protection Agency, Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office for the Office of Drinking Water, Washington, DC.
22. Franchini I, Cavatorta and Falzoi M. Early indicators of renal damage in workers exposed to organic solvents. Int Arch Occup Environ Health. 1983; 52:1-9.
23. Padilla SS, Lyerly DP. Effects of p-xylene inhalation on the axonal transport in the rat retinal ganglion cells. Toxicol Appl Pharmacol. 1990; 101: 390-98.
24. Andersson K, Fuxe K and Nilsen OG. Production of discrete changes in dopamine and noradrenaline levels and turnover in various parts of the rat brain following exposure to xylene, ortho-, meta-, and para-xylene, and ethylbenzene. Toxicol Appl Pharmacol. 1981; 60:535-48.
25. Savolainen H and Pfaffli P. Dose-dependent neurochemical changes during shortterm inhalation exposure to m-xylene. Arch. Toxicol. 1980; 45:117-22.
26. Hino R, Nishio D, Kabashima K and Tokura Y. Percutaneous penetration via hand eczema is the major accelerating factor for systemic absorption of toluene and xylene during car spray painting. Contact dermatitis. 2008; 58: 76-79.
27. Gunasekar PG, Rogers JV, Kabbur MB, Garrett CM, Brinkley WW and McDougal JN. Molecular and histological responses in rat skin exposed to m-xylene. J Biochem Mol Toxicology. 2003; 17: 92-94.
28. Bronstein AC, Currance PL. Emergency care for hazardous materials exposure. 1988; St. Louis, MO: The C.V. Mosby Company, 221-22.
29. Ellenhorn MJ, Barceloux DG. Medical toxicology: Diagnosis and treatment of human poisoning. 1988; New York, NY: Elsevier, 962-64.
30. Sevcik P, Hep A and Peslova M. Intravenous xylene poisoning. Intensive Care Medicine. 1992; 18:377-78.
31. Schwope AD, Costas PP, Jackson JO, Stull JO, Weitzman DJ. Guidelines for the selection of chemical protective clothing. 1987; 3rd edition. Cambridge, MA: Arthur D. Little Company.
32. Ankle MR, Joshi PS. A study to evaluate the efficacy of xylene-free hematoxylin and eosin staining procedure as compared to the conventional hematoxylin and eosin staining. An experimental study. J Oral Maxillofac Pathol. 2011; May; 15(2): 161-7.
33. Metgud R, Astekar MS, Soni A, Naik S, Vanishree M. Conventional xylene and xylene-free methods for routine histopathological preparation of tissue section. Biotech Histochem. 2013; July; 88(5): 235-41.
34. Kunhua W, Chuming F, Tao L, Yanmei Y, Xin Y, Xioming Z, Xuezhong G, Xun L. A novel non-toxic xylene substitute SBO for histology. Afr J Tradit Complement Altern Med. 2011; Oct 2; 9(1): 43-9.
35. Premalatha BR, Patil S, Rao RS, Indu M. J Contemp Dent Prac. 2013 Mar 1; 14(2): 281-6. Mineral Oil-A biofriendly substitute for xylene in deparaffinisation: A novel method. J Contemp Dent Prac. 2013; Mar 1; 14(2):281-6.
36. Buesa RJ, Peshkov MV. Complete elimination of xylene in practice of a histology lab. Arkh Patol. 2011; Jan-Feb; 73(1): 54-60.
37. Beusa RJ, Peshkov MV. Histology without xylene. Ann Diagn Pathol. 2009; 13: 246-56.
38. Chemical hazards. Available from http;// www.worksafe.ca//certmanual/ch 08.html (Last cited on 2009 Dec 16).