Fromgenetic improvementtocommercial-scalemassculture of a Chilean strain of the green microalga Haematococcus pluvialis with enhanced productivity of the red ketocarotenoid astaxanthin

AoB PLANTS

Volumn 5, Issue , 2013, Pages

  Gómez, Patricia I ^a   Inostroza, Ingrid ^a   Pizarro, Mario ^b   Pérez, Jorge ^b  

^a Facultad de Ciencias Naturales y Oceanograficas   (Chile)

^b Pigmentos Naturales S A   (Chile)

Author keywords

Astaxanthin; Commercial sized open ponds; Haematococcus pluvialis mutant; North Chile; Random mutagenesis

Indexed keywords

EID: 84893545597     PISSN: None     EISSN: 20412851     Source Type: Journal    
DOI: 10.1093/aobpla/plt026     Document Type: Article

References (36)

1. Boussiba S. 2000. Carotenogenesis in the green alga Haematococcus pluvialis: cellular physiologyand stress response. Physiologia Plantarum 108:111-117. (Pubitemid 30130362)
2. Bubrick P. 1991. Production of astaxanthin from Haematococcus. Bioresource Technology 38:237-239.
3. Chatuverdi R, Fujita Y. 2006. Isolation of enhanced eicosapentaenoic acid producing mutants of Nannochloropsis oculata ST-6 using ethyl methane sulfonate induced mutagenesis techniques and their characterization at mRNA transcript level. Phycological Research 54:208-219. (Pubitemid 44400916)
4. Chatuverdi R, Rao S, Amin M, Fujita Y. 2004. Isolation of quizalofop-resistant mutants of Nannochloropsis oculata (Eustigmatophyceae) with high eicosapentaenoic acid following N-methyl-N-nitrosourea induced random mutagenesis. Journal of Phycology 16:135-144. (Pubitemid 39384838)
5. Chen Y, Li D, LuW, Xing J, Hui B, Han Y. 2003. Screening and characterization of astaxanthin-hyperproducing mutants of Haematococcus pluvialis. Biotechnology Letters 25:527-529. (Pubitemid 36429662)
6. Christiansen R, Torrissen OJ. 1997. Effects of dietary astaxanthin supplementation on fertilization and egg survival in Atlantic salmon (Salmo salar L.). Aquaculture 153:51-62. (Pubitemid 27372357)
7. Chumpolkulwong N, Kakizono T, Handa T, Nishio N. 1997. Isolation and characterization of compactin resistant mutants of an astaxanthin synthesizing green alga Haematococcus pluvialis. Biotechnology Letters 19:299-302. (Pubitemid 27135808)
8. Fabregas J, Dom?nguez A, Regueiro M, Maseda A, Otero A. 2000. Optimization of culture medium for the continuous cultivation of the microalga Haematococcus pluvialis. Applied Microbiology and Biotechnology 53:530-535. (Pubitemid 30341402)
9. Fujii K, Imazato E, Nakashima H, Ooi O, Saeki A. 2006. Isolation of the non-fastidious microalga with astaxanthin-accumulating property and its potential for application to aquaculture. Aquaculture 262:285-293. (Pubitemid 44666904)
10. Grunewald K, Eckert M, Hirschberg J. 2000. Phytoene desaturase is localized exclusively in the chloroplast and upregulated at the mRNA level during accumulation of secondary carotenoids in Haematococcus pluvialis (Volvocales, Chlorophyceae). Plant Physiology 122:1261-1268. (Pubitemid 30221407)
11. Guerin M, Huntley M, Olaizola M. 2003. Haematococcus astaxanthin: applications for human health and nutrition. Trends in Biotechnology 21:210-216. (Pubitemid 36515074)
12. Jin E, Lee C, Polle J. 2006. Secondary carotenoid accumulation in Haematococcus (Chlorophyceae). Journal ofMicrobiologyandBiotechnology16:821-831 (Pubitemid 43984680)
13. Kathiresan S, Sarada R. 2009. Towards genetic improvement of commercially important microalga Haematococcus pluvialis for biotech applications. Journal of Applied Phycology 21:553-558.
14. Kobayashi M, Kakizono T, Nishio N, Nagai S, Kurimura Y, Tsuji Y. 1997. Antioxidant role of astaxanthin in the green alga Haematococcus pluvialis. Applied Microbiology and Biotechnology 48:351-356. (Pubitemid 27430085)
15. Krishna K, Mohanty P. 1998. Secondary carotenoid production in green algae. Journal of Scientific and Industrial Research 57: 51-63. (Pubitemid 128497305)
16. Li J, Zhu D, Niu J, Shen S, Wang G. 2011. An economic assessment of astaxanthin production by large scale cultivation of Haematococcus pluvialis. Biotechnology Advances 29:568-574.
17. Li Y, Sommerfeld M, Chen F, Hu Q. 2010. Effect of photon flux densities on regulation of carotenogenesisand cell viability of Haematococcus pluvialis (Chlorophyceae). Journal of Phycology 22:253-263.
18. Lopez Alonso D, Segura del Castillo C, Molina Grima E, Cohen Z. 1996. First insights into improvement of eicosapentaenoic content in Phaeodactylum tricornutum (Bacillariophyceae) by induced mutagenesis. Journal of Phycology 32:339-345. (Pubitemid 26263714)
19. Lorenz RT, Cysewski GR. 2000. Commercial potential for Haematococcus microalgae as a natural source of astaxanthin. Trends in Biotechnology 18:160-167. (Pubitemid 30171334)
20. Lotan T, Hirschberg J. 1995. Cloning and expression in Escherichia coli of the gene encoding beta-C4-oxygenase, that converts betacarotene to the ketocarotenoid canthaxanthin in Haematococcus pluvialis. FEBS Letters 364:125-128.
21. Meireles L, Guedes A, Malcata X. 2002. Increase of the yields of eicosapentaenoic and docosahexaenoic acids by the microalga Pavlova lutheri following random mutagenesis. Biotechnology and Bioengineering 81:50-55. (Pubitemid 38181637)
22. Olaizola M. 2003. Commercial development of microalgal biotechnology: from test tube to the marketplace. Biomolecular Engineering 20:459-466. (Pubitemid 36959698)
23. Potvin G, Zhang Z. 2010. Strategies for high-level recombinant protein expression in transgenic microalgae: a review. Biotechnology Advances 28:910-918.
24. Starr RC, Zeikus JA. 1987. UTEX-the culture collection of algae at the University of Texas at Austin. Journal of Phycology 29:1-106.
25. Steinbrenner J, Linden H. 2001. Regulation of two carotenoid biosynthesis genes encoding for phytoene synthase and carotenoid hydroxylase during stress-induced astaxanthin formation in the green alga Haematococcus pluvialis. Plant Physiology 125: 810-817. (Pubitemid 32169888)
26. Steinbrenner J, Linden H. 2003. Light induction of carotenoid biosynthesis genes in the green alga Haematococcus pluvialis: regulation by photosynthetic redox control. Plant Molecular Biology 52: 343-356. (Pubitemid 36761649)
27. Steinbrenner J, Sandmann G. 2006. Transformation of the green alga Haematococcus pluvialis with a phytoene desaturase for accelerated astaxanthin biosynthesis. Applied and Environmental Microbiology 72:7477-7484. (Pubitemid 44927647)
28. Sun Z,Cunningham F, Gantt E. 1998. Differential expression oftwo isopentenyl pyrophosphate isomerases and enhanced carotenoid accumulation in a unicellular chlorophyte. Proceedings of the National Academy of Sciences of the USA 95:11482-11488. (Pubitemid 28450155)
29. Tjahjono AE, Kakisono T, Hayama Y, Nishio N, Nagai S. 1994. Isolation of resistantmutants against carotenoid biosynthesis inhibitors for a green alga Haematococcus pluvialis, and their hybrid formation by protoplast fusion for breeding of higher astaxanthin producers. Journal of Fermentation and Bioengineering 77:352-357. (Pubitemid 24162780)
30. Tripathi U, Venkateshwaran G, Sarada R, Ravishankar GA. 2001. Studies on Haematococcus pluvialis for improved production of astaxanthin by mutagenesis. World Journal of Microbiology and Biotechnology 17:143-148. (Pubitemid 34853708)
31. Valenzuela A. 2005. Art?culo de actualizacion el Salmon: un banquete de salud. Salmon: a health banquet. Revista Chilena de Nutricion 32:8-17.
32. Wegmann K, Metzner H. 1971. Synchronization of Dunaliella salina cultures. Archiv fur Mikrobiologie 78:360-367.
33. Yen Doan TT, Obbard JP. 2012. Enhanced intracellular lipid in Nannochloropsis sp. via random mutagenesis and flow cytometric cell sorting. Algal Research 1:17-21.
34. Yong YYR, Lee KK. 1991. Do carotenoids play a photoprotective role in the cytoplasm of Haematococcus lacustris (Chlorophyta)? Phycologia 30:257-261.
35. Zhang B, Geng Y, Li Z, Hu H, Li Y. 2009. Production of astaxanthin from Haematococcus in open pond by two-stage growth one-step process. Aquaculture 295:275-281.
36. Zhang DH, Lee YK. 1997. Enhanced accumulation of secondary carotenoids in a mutant of the green alga, Chlorococcum sp. Journal of Applied Phycology 9:459-463. (Pubitemid 28111472)