Poly(ethylene glycol)-modified PAMAM-Fe3O4- doxorubicin triads with the potential for improved therapeutic efficacy: Generation-dependent increased drug loading and retention at neutral pH and increased release at acidic pH

Langmuir

Volumn 30, Issue 4, 2014, Pages 1004-1011

  Nigam, Saumya ^a,b   Chandra, Sudeshna ^c   Newgreen, Donald F ^b   Bahadur, Dhirendra ^c   Chen, Qizhi ^b  

^a IITB MONASH RESEARCH ACADEMY   (India)

^b MONASH UNIVERSITY   (Australia)

^c INDIAN INSTITUTE OF TECHNOLOGY BOMBAY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOCARCINOMA CELLS; DRUG-DELIVERY SYSTEMS; LOADING EFFICIENCY; MAGNETIC NANO-PARTICLES; RELEASE EFFICIENCY; THERAPEUTIC EFFECTS; THERAPEUTIC EFFICACY; THERAPEUTIC EFFICIENCY;

AMINO ACIDS; CELL CULTURE; CHEMOTHERAPY; DENDRIMERS; DRUG INTERACTIONS; EFFICIENCY; NANOPARTICLES; POLYETHYLENE GLYCOLS; SYNTHESIS (CHEMICAL);

FUNCTIONAL POLYMERS;

ANTINEOPLASTIC ANTIBIOTIC; DENDRIMER; DOXORUBICIN; DRUG CARRIER; GLUTAMIC ACID; MACROGOL DERIVATIVE; MAGNETITE; MAGNETITE NANOPARTICLE; PAMAM STARBURST;

ARTICLE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; DRUG FORMULATION; FLUORESCENCE MICROSCOPY; HELA CELL LINE; HUMAN; PH; STATIC ELECTRICITY; SYNTHESIS;

ANTIBIOTICS, ANTINEOPLASTIC; CELL SURVIVAL; DENDRIMERS; DOXORUBICIN; DRUG CARRIERS; DRUG COMPOUNDING; FERROSOFERRIC OXIDE; GLUTAMIC ACID; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; MAGNETITE NANOPARTICLES; MICROSCOPY, FLUORESCENCE; POLYETHYLENE GLYCOLS; STATIC ELECTRICITY;

EID: 84893534042     PISSN: 07437463     EISSN: 15205827     Source Type: Journal    
DOI: 10.1021/la404246h     Document Type: Article

References (36)

1. Vial, T.; Descotes, J. Immunosuppressive drugs and cancer Toxicology 2003, 185, 229-240 (Pubitemid 36173740)
2. Raschi, E.; Vasina, V.; Ursino, M. G.; Boriani, G.; Martoni, A.; De Ponti, F. Anticancer drugs and cardiotoxicity: insights and perspectives in the era of targeted therapy Pharmacol. Ther. 2010, 125, 196-218
3. Hayward, R.; Hydock, D.; Gibson, N.; Greufe, S.; Bredahl, E.; Parry, T. Tissue retention of doxorubicin and its effects on cardiac, smooth, and skeletal muscle function J. Physiol. Biochem. 2013, 69, 177-187
4. Shen, M.; Shi, X. Dendrimer-based organic/inorganic hybrid nanoparticles in biomedical applications Nanoscale 2010, 2, 1596-1610
5. Chandra, S.; Barick, K. C.; Bahadur, D. Oxide and hybrid nanostructures for therapeutic applications Adv. Drug Delivery Rev. 2011, 63, 1267-1281
6. Løkling, K.-E.; Skurtveit, R.; Fossheim, S. L.; Smistad, G.; Henriksen, I.; Klaveness, J. pH-sensitive paramagnetic liposomes for MRI: assessment of stability in blood Magn. Reson. Imag. 2003, 21, 531-540 (Pubitemid 36899086)
7. Pakula, T.; Minkin, P.; Matyjaszewski, K., Polymers, Particles, and Surfaces with Hairy Coatings: Synthesis, Structure, Dynamics, and Resulting Properties. In Advances in Controlled/Living Radical Polymerization; American Chemical Society: Washington, DC, 2003; Vol. 854, pp 366-382.
8. Mignani, S.; Kazzouli, S. E.; Bousmina, M.; Majoral, J.-P. Dendrimer space concept for innovative nanomedicine: A futuristic vision for medicinal chemistry Prog. Polym. Sci. 2013, 38 993-1008
9. Zhu, J.; Shi, X. Dendrimer-based nanodevices for targeted drug delivery applications J. Mater. Chem. B 2013, 1, 4199-4211
10. Li, J.; Li, J.; Xu, S.; Zhang, D.; Liu, D. Hydrophobic oligopeptide-based star-block copolymers as unimolecular nanocarriers for poorly water-soluble drugs Colloids Surf., B 2013, 110, 183-190
11. Pradhan, P.; Giri, J.; Rieken, F.; Koch, C.; Mykhaylyk, O.; Döblinger, M.; Banerjee, R.; Bahadur, D.; Plank, C. Targeted temperature sensitive magnetic liposomes for thermo-chemotherapy J. Controlled Release 2010, 142, 108-121
12. Sinéad M Ryan, G. M.; Wang, Xuexuan; Haddleton, David M; Brayden, D. J. Advances in PEGylation of important biotech molecules: delivery aspects Expert Opin. Drug Delivery 2008, 5, 371-383 (Pubitemid 351721718)
13. Labieniec, M.; Watala, C. PAMAM dendrimers-diverse biomedical applications. Facts and unresolved questions Cent. Eur. J. Biol. 2009, 4, 434-451
14. Esfand, R.; Tomalia, D. A. Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications Drug Discovery Today 2001, 6, 427-436 (Pubitemid 32328297)
15. Mikiciuk-Olasik, E.; Szymański, P.; Markowicz, M. Nanotechnology in pharmaceutical and biomedical applications: dendrimers Nano 2011, 06, 509-539
16. Wu, X.; He, X.; Zhong, L.; Lin, S.; Wang, D.; Zhu, X.; Yan, D. Water-soluble dendritic-linear triblock copolymer-modified magnetic nanoparticles: preparation, characterization and drug release properties J. Mater. Chem. 2011, 21, 13611-13620
17. Lopez-Heredia, M. A.; Bongio, M.; Cuijpers, V. M. J. I.; van Dijk, N. W. M.; van den Beucken, J. J. J. P.; Wolke, J. G. C.; Jansen, J. A. Bone formation analysis: effect of quantification procedures on the study outcome Tissue Eng., Part C 2012, 18, 369-373
18. Castelli, D.; Boffa, C.; Giustetto, P.; Terreno, E.; Aime, S. Design and testing of paramagnetic liposome-based CEST agents for MRI visualization of payload release on pH-induced and ultrasound stimulation J. Biol. Inorg. Chem. 2013, 18, 1-8
19. Wang, F. P.; Mu, H. P.; Zhang, J. Y.; Li, W. X.; Wang, Q. Z.; Du, X. Z. Study on preparation and swelling kinetics of P(AA-co-C8PhEO10Mac) pH-sensitive hydrogel in vitro drug release study J. Appl. Polym. Sci. 2013, 130 1981-1989
20. Ding, F.; Shi, X.; Jiang, Z.; Liu, L.; Cai, J.; Li, Z.; Chen, S.; Du, Y. Electrochemically stimulated drug release from dual stimuli responsive chitin hydrogel J. Mater. Chem. B 2013, 1, 1729-1737
21. Peng, J.; Qi, T.; Liao, J.; Chu, B.; Yang, Q.; Li, W.; Qu, Y.; Luo, F.; Qian, Z. Controlled release of cisplatin from pH-thermal dual responsive nanogels Biomaterials 2013, 34, 8726-8740
22. Jaiswal, M. K.; Banerjee, R.; Pradhan, P.; Bahadur, D. Thermal behavior of magnetically modalized poly(N-isopropylacrylamide)-chitosan based nanohydrogel Colloids Surf., B 2010, 81, 185-194
23. Gary-Bobo, M.; Mir, Y.; Rouxel, C.; Brevet, D.; Hocine, O.; Maynadier, M.; Gallud, A.; Da Silva, A.; Mongin, O.; Blanchard-Desce, M.; Richeter, S.; Loock, B.; Maillard, P.; Morère, A.; Garcia, M.; Raehm, L.; Durand, J.-O. Multifunctionalized mesoporous silica nanoparticles for the in vitro treatment of retinoblastoma: drug delivery, one and two-photon photodynamic therapy Int. J. Pharm. 2012, 432, 99-104
24. Tannock, I. F.; Rotin, D. Acid pH in tumors and its potential for therapeutic exploitation Cancer Res. 1989, 49, 4373-4384 (Pubitemid 19208329)
25. Li, Y.; He, H.; Jia, X.; Lu, W.-L.; Lou, J.; Wei, Y. A dual-targeting nanocarrier based on poly(amidoamine) dendrimers conjugated with transferrin and tamoxifen for treating brain gliomas Biomaterials 2012, 33, 3899-3908
26. He, H.; Li, Y.; Jia, X.-R.; Du, J.; Ying, X.; Lu, W.-L.; Lou, J.-N.; Wei, Y. PEGylated Poly(amidoamine) dendrimer-based dual-targeting carrier for treating brain tumors Biomaterials 2011, 32, 478-487
27. Rouhollah, K.; Pelin, M.; Serap, Y.; Gozde, U.; Ufuk, G. Doxorubicin loading, release, and stability of polyamidoamine dendrimer-coated magnetic nanoparticles J. Pharm. Sci. 2013, 102 1825-1835
28. Chandra, S.; Dietrich, S.; Lang, H.; Bahadur, D. Dendrimer-doxorubicin conjugate for enhanced therapeutic effects for cancer J. Mater. Chem. 2011, 21, 5729-5737
29. Pietrzak, M.; Wieczorek, Z.; Stachelska, A.; Darzynkiewicz, Z. Interactions of chlorophyllin with acridine orange, quinacrine mustard and doxorubicin analyzed by light absorption and fluorescence spectroscopy Biophys. Chem. 2003, 104, 305-313 (Pubitemid 36794482)
30. Szulawska, A.; Gniazdowski, M.; Czyz, M. Sequence specificity of formaldehyde-mediated covalent binding of anthracycline derivatives to DNA Biochem. Pharmacol. 2005, 69, 7-17
31. Das, K.; Jain, B.; Dube, A.; Gupta, P. K. pH dependent binding of chlorin-p6 with phosphatidyl choline liposomes Chem. Phys. Lett. 2005, 401, 185-188
32. Vichai, V.; Kirtikara, K. Sulforhodamine B colorimetric assay for cytotoxicity screening Nat. Protocols 2006, 1, 1112-1116
33. Patterson, A. L. The Scherrer formula for X-ray particle size determination Phys. Rev. 1939, 56, 978-982
34. Max, J.-J.; Chapados, C. Infrared spectroscopy of aqueous carboxylic acids: comparison between different acids and their salts J. Phys. Chem. A 2004, 108, 3324-3337
35. Fajaroh, F.; Setyawan, H.; Nur, A.; Lenggoro, I. W. Thermal stability of silica-coated magnetite nanoparticles prepared by an electrochemical method Adv. Powder Technol. 2013, 24, 507-511
36. Markowicz, M.; Szymański, P.; Ciszewski, M.; Kłys, A.; Mikiciuk-Olasik, E. Evaluation of poly(amidoamine) dendrimers as potential carriers of iminodiacetic derivatives using solubility studies and 2D-NOESY NMR spectroscopy J. Biol. Phys. 2012, 38, 637-656