Enhancement of immunogenicity and efficacy of a plasmid DNA rabies vaccine by nanoformulation with a fourth-generation amine-terminated poly(ether imine) dendrimer

International Journal of Nanomedicine

Volumn 9, Issue 1, 2014, Pages 627-634

  Ullas, Padinjaremattathil Thankappan ^a   Madhusudana, Shampur Narayan ^b   Desai, Anita ^b   Sagar, Bhadravathi Kenchappa Chandrasekhar ^b   Jayamurugan, Govindasamy ^c   Rajesh, Yamajala Bhaskara Rama Durga ^c   Jayaraman, Narayanaswami ^c  

^a SASTRA UNIVERSITY   (India)

^b NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

^c INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

Nonviral gene delivery; Rabies prophylaxis

Indexed keywords

NONVIRAL GENE DELIVERY; RABIES PROPHYLAXIS;

AMINES; ANIMALS; BRAIN; DENDRIMERS; DRUG COMPOUNDING; FEMALE; IMINES; MALE; MICE; NANOCAPSULES; PLASMIDS; RABIES; RABIES VACCINES; RABIES VIRUS; TREATMENT OUTCOME; VACCINES, DNA;

EID: 84893515875     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S53415     Document Type: Article

References (28)

1. WHO Fact Sheet No 99 [webpage on the Internet]. WHO; 2010 [cited June 10, 2011]. Available from: http://www.paho.org/common/Display.asp?Lang=E&RecID=10209. Accessed September 22, 2013.
2. Knobel DL, Cleaveland S, Coleman PG, et al. Re-evaluating the burden of rabies in Africa and Asia. Bull World Health Organ. 2005;83(5): 360-368.
3. Bahloul C, Taieb D, Diouani MF, et al. Field trials of a very potent rabies DNA vaccine which induced long lasting virus neutralizing antibodies and protection in dogs in experimental conditions. Vaccine. 2006;24(8):1063-1072.
4. Lodmell DL, Ray NB, Parnell MJ, et al. DNA immunization protects non-human primates against rabies virus. Nat Med. 1998;4(8):949-952.
5. Lodmell DL, Ray NB, Ulrich JT, Ewalt LC. DNA vaccination of mice against rabies virus: effects of the route of vaccination and the adjuvant monophosphoryl lipid A (MPL). Vaccine. 2000;18(11-12):1059-1066.
6. Lodmell DL, Parnell MJ, Bailey JR, Ewalt LC, Hanlon CA. Rabies DNA vaccination of non-human primates: post-exposure studies using gene gun methodology that accelerates induction of neutralizing antibody and enhances neutralizing antibody titers. Vaccine. 2002;20(17-18): 2221-2228.
7. Lodmell DL, Parnell MJ, Weyhrich JT, Ewalt LC. Canine rabies DNA vaccination: a single-dose intradermal injection into ear pinnae elicits elevated and persistent levels of neutralizing antibody. Vaccine. 2003;21(25-26):3998-4002.
8. Cupillard L, Juillard V, Latour S, et al. Impact of plasmid supercoiling on the efficacy of a rabies DNA vaccine to protect cats. Vaccine. 2005;23(16):1910-1916.
9. Fischer L, Minke J, Dufay N, Baudu P, Audonnet JC. Rabies DNA vaccine in the horse: strategies to improve serological responses. Vaccine. 2003;21(31):4593-4596.
10. Margalith M, Vilalta A. Sustained protective rabies neutralizing antibody titers after administration of cationic lipid-formulated pDNA vaccine. Genet Vaccines Ther. 2006;4:2.
11. Kaur M, Saxena A, Rai A, Bhatnagar R. Rabies DNA vaccine encoding lysosome-targeted glycoprotein supplemented with Emulsigen-D confers complete protection in preexposure and postexposure studies in BALB/c mice. FASEB J. 2010;24(1):173-183.
12. Astruc D, Boisselier E, Ornelas C. Dendrimers designed for functions: from physical, photophysical, and supramolecular properties to applications in sensing, catalysis, molecular electronics, photonics, and nanomedicine. Chem Rev. 2010;110(4):1857-1959.
13. Krishna TR, Jayaraman N. Synthesis of poly(propyl ether imine) dendrimers and evaluation of their cytotoxic properties. J Org Chem. 2003;68(25):9694-9704.
14. Jayamurugan G, Jayaraman N. Synthesis of large generation poly(propyl ether imine) (PETIM) dendrimers. Tetrahedron. 2006;62(41): 9582-9588.
15. Thankappan UP, Madhusudana SN, Desai A, Jayamurugan G, Rajesh YB, Jayaraman N. Dendritic poly(ether imine) based gene delivery vector. Bioconjug Chem. 2011;22(2):115-119.
16. Muhamuda K, Madhusudana SN, Ravi V. Use of neutralizing murine monoclonal antibodies to rabies glycoprotein in passive immunotherapy against rabies. Hum Vaccin. 2007;3(5):192-195.
17. Harris JR. Negative staining of thinly spread biological samples. Methods Mol Biol. 2007;369:107-142.
18. Smith JS, Yager PA, Baer GM. A rapid fluorescent focus inhibition (RFFIT) for determining rabies virus-neutralizing antibody. In: Meslin FX, Kaplan MM, Koprowsky H, editors. Laboratory Techniques in Rabies. 4th ed. Geneva: World Health Organization; 1996: 181-192.
19. WHO Expert Committee on Rabies. World Health Organ Tech Rep Ser. 1992;824:1-84.
20. Mintzer AM, Simanek EE. Nonviral vectors for gene delivery. Chem Rev. 2009;109(2):259-302.
21. Anita Desai et al, inventors; Poly(ether imine) dendrimers and uses thereof. Indian Patent. WO2012090223 A1. 2011, Dec 28.
22. Shcharbin D, Pedziwiatr E, Bryszewska M. How to study dendriplexes I: Characterization. J Control Release. 2009;135(3):186-197.
23. Patial S, Chaturvedi VK, Rai A, et al. Virus neutralizing antibody response in mice and dogs with a bicistronic DNA vaccine encoding rabies virus glycoprotein and canine parvovirus VP2. Vaccine. 2007;25(20):4020-4028.
24. Panyam J, Labhasetwar V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Deliv Rev. 2003;55(3): 329-347.
25. Dutta T, Garg M, Jain NK. Poly(propyleneimine) dendrimer and dendrosome mediated genetic immunization against hepatitis B. Vaccine. 2008;26(27-28):3389-3394.
26. Balenga NA, Zahedifard F, Weiss R, Sarbolouki MN, Thalhamer J, Rafati S. Protective efficacy of dendrosomes as novel nano-sized adjuvants for DNA vaccination against birch pollen allergy. J Biotechnol. 2006;124:602-614.
27. Ramya R, Verma PC, Chaturvedi VK, et al. Poly(lactide-co-glycolide) microspheres: a potent oral delivery system to elicit systemic immune response against inactivated rabies virus. Vaccine. 2009;27(15): 2138-2143.
28. Kaur M, Rai A, Bhatnagar R. Rabies DNA vaccine: no impact of MHC class I and class II targeting sequences on immune response and protection against lethal challenge. Vaccine. 2009;27(15):2128-2137.