Rabies DNA vaccine encoding lysosome-targeted glycoprotein supplemented with Emulsigen-D confers complete protection in preexposure and postexposure studies in BALB/c mice

FASEB Journal

Volumn 24, Issue 1, 2010, Pages 173-183

  Kaur, Manpreet ^a   Saxena, Ankur ^b   Rai, Anant ^b   Bhatnagar, Rakesh ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

^b INDIAN VETERINARY RESEARCH INSTITUTE   (India)

Author keywords

Encephalitis; Intramuscular administration; Prophylactic; Rabies virus neutralizing antibodies; Survival; Therapeutic

Indexed keywords

ADJUVANT; DNA VACCINE; EMULSIGEN; EMULSIGEN D; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2A ANTIBODY; RABIES VACCINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; FEMALE; GENE GUN; IMMUNITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RABIES; RABIES VIRUS; VACCINATION;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, ORAL; ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; BIOLISTICS; DOG DISEASES; DOGS; FEMALE; GLYCOPROTEINS; INJECTIONS, INTRAMUSCULAR; INTERFERON-GAMMA; INTERLEUKIN-4; LYSOSOMES; MICE; MICE, INBRED BALB C; PLASMIDS; RABIES; RABIES VACCINES; RABIES VIRUS; VACCINES, DNA; VIRAL PROTEINS;

MUS; RABIES VIRUS;

EID: 75149139913     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.09-138644     Document Type: Article

References (48)

1. World Health Organization. (2007) Wkly. Epidemiol. Rec. 82, 425-436
2. Dodet, B., and Asian Rabies Expert Bureau (AREB). (2007) An important date in rabies history. Vaccine 25, 8647-8650
3. Beran, J., Honegr, K., Banzhoff, A., and Malerczyk, C. (2005) Potency requirements of rabies vaccines administered intradermally using the Thai Red Cross regimen: investigation of the immunogenicity of serially diluted purified chick embryo cell rabies vaccine. Vaccine 23, 3902-3907
4. Wolff, J. A., Malone, R. W., Williams, P., Chong, W., Acsadi, G., Jani, A., and Felgner, P. L. (1990) Direct gene transfer into mouse muscle in vivo. Science 247, 1465-1468
5. Kaur, M., Rai, A., and Bhatnagar, R. (2009) Rabies DNA vaccine: no impact of MHC class I and class II targeting sequences on immune response and protection against lethal challenge. Vaccine 27, 2128-2137
6. Alves, A. M. B., Lásaro, M. O., Almeida, D. F., and Ferreira, L. C. S. (1998) Epitope specificity of antibodies raised against enterotoxigenic Escherichia coli CFA/I fimbriae in mice immunized with naked DNA. Vaccine 16, 9-15
7. Wang, R., Doolan, D. L., Le, T. P., Hedstrom, R. C., Coonan, K. M., Charoenvit, Y., Jones, T. R., Hobart, P., Margalith, M., Ng, J., Weiss, W. R., Sedegah, M., de Taisne, C., Norman, J. A., and Hoffman, S. L. (1998) Induction of antigen-specific cytotoxic T-lymphocytes in humans by a malaria DNA vaccine. Science 282, 476-480
8. Kim, N., Kwon, S. S., Lee, J., Kim, S., and Yoo, T. J. (2006) Protective effect of the DNA vaccine encoding the major house dust mite allergens on allergic inflammation in the murine model of house dust mite allergy. Clin. Mol. Allergy 4, 1-9
9. Timmerman, J. M., Singh, G., Hermanson, G., Hobart, P., Czerwinski, D. K., Taidi, B., Rajapaksa, R., Caspar, C. B., van Beckhoven, A., and Levy, R. (2002) Immunogenicity of a plasmid DNA vaccine encoding chimeric idiotype in patients with B-cell lymphoma. Cancer Res. 62, 5845-5852
10. Dobaño, C., Rogers, W. O., Gowda, K., and Doolan, D. L. (2007) Targeting antigen to MHC class I and class II antigen presentation pathways for malaria DNA vaccines. Immunol. Lett. 111, 92-102
11. Hanly, W. C., Artwohl, J. E., and Bennett, B. T. (1995) Review of polyclonal antibody production procedures in mammals and poultry. ILAR J. 37, 93-118
12. Schunk, M. K., and Macallum, G. E. (2005) Applications and optimization of immunization procedures. ILAR J. 46, 241-257
13. Greenland, J. R., and Letvin, N. L. (2007) Chemical adjuvants for plasmid DNA vaccines. Vaccine 25, 3731-3741
14. Smith, J. S., Yager, P. A., and Baer, G. M. (1996) A rapid fluorescent focus inhibition test (RFFIT) for determining rabies virus-neutralizing antibody. In Laboratory Techniques in Rabies (Meslin, F. X., Kaplan, M. M., and Koprowski, H., eds) pp. 181-192, World Health Organization, Geneva
15. Conry, R. M., Curiel, D. T., Strong, T. V., Moore, S. E., Allen, K. O., Barlow, D. L., Shaw, D. R., and LoBuglio, A. F. (2002) Safety and immunogenicity of DNA vaccine encoding carcino-embryonic antigen and hepatitis B surface antigen in colorectal carcinoma patients. Clin. Cancer Res. 8, 2782-2787
16. Kirman, J. R., and Seder, R. A. (2003) DNA vaccination: the answer to stable, protective T-cell memory? Curr. Opin. Immunol. 15, 471-476
17. Ulmer, J. B., Deck, R. R., Dewitt, C. M., Donnhly, J. I., and Liu, M. A. (1996) Generation of MHC class I-restricted cytotoxic T lymphocytes by expression of a viral protein in muscle cells: antigen presentation by non-muscle cells. Immunology 89, 59-67
18. Torres, C. A., Iwasaki, A., Barber, B. H., and Robinson, H. L. (1997) Differential dependence on target site tissue for gene gun and intramuscular DNA immunization. J. Immunol. 158, 4529-4532
19. Corr, M., von Damm, A., Lee, D. J., and Tighe, H. (1999) In vivo priming by DNA injection occurs predominantly by antigen transfer. J. Immunol. 163, 4721-4727
20. Turing, T. (1999) The immunology of cutaneous DNA immunization. Curr. Opin. Mol. Ther. 1, 216-225
21. + T cell responses and anti-tumor effects generated by DNA vaccine administered through gene gun, biojector and syringe Vaccine 21, 4036-4041
22. Ito, K., Shinohara, N., and Kato, S. (2003) DNA immunization via intramuscular and intradermal routes using a gene gun provides different magnitudes and durations on immune response. Mol. Immunol. 39, 847-854
23. Dileo, J., Miller, T. E., Chesnoy, S., and Huang, L. (2003) Gene transfer to subdermal tissues via a new gene gun design 2003. Hum. Gene Ther. 14, 79-87
24. Hynes, J. R. (2004) Particle-mediated DNA vaccine delivery to the skin. Expert Opin. Biol. Ther. 4, 889-900
25. Perrin, P., Jacob, Y., Aguilar-Setien, A., Loza-Rubio, E., Jallet, C., Desmezieres, E., Aubertd, M., Cliquetd, F., and Tordoa, N. (2000) Immunization of dogs with a DNA vaccine induces protection against rabies virus. Vaccine 18, 479-486
26. Bahloul, C., Taieb, D., Diouani, M. F., Ahmed, S. B. H., Chtourou, Y., B'chir, B. I., Kharmachi, H., and Dellagi, K. (2005) Field trials of a very potent rabies DNA vaccine which induced long lasting virus neutralizing antibodies and protection in dogs in experimental conditions. Vaccine 24, 1063-1072
27. Lodmell, D.L., Ray, N. B., and Ewalt, L. C. (1998) Gene gun particle-mediated vaccination with plasmid DNA confers protective immunity against rabies virus infection. Vaccine 16, 115-118
28. Tesoro, C. E., Hernández González, R., Morales, R. A., and Aguilar-Setién, A. (2006) Rabies DNA vaccination by the intranasal route in dogs. Dev. Biol. (Basel) 125, 221-231
29. Fynan, E. F., Webster, R. G., Fuller, D. H., Haynes, J. R., Santoro, J. C., and Robinson, H. L. (1993) DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations. Proc. Natl. Acad. Sci. U. S. A. 90, 11478-11482
30. Conn, A., Durrant, L., and Spendlove, I. Delivery of pCMV-S DNA using the Helios gene gun system is superior to intramuscular injection in BALB/c mice: gene transfer. Bio-Rad Technical Note 2726. Bio-Rad Laboratories, Hercules, CA, USA
31. Van Drunen Little-van den Hurk, S., Babiuk, S. L., and Babiuk, L. A. (2004) Strategies for improved formulation and delivery of DNA vaccines to veterinary target species. Immunol. Rev. 199, 113-125
32. Pavlenko, M., Roos, A. K., Lundqvist, A., Palmborg, A., Miller, A. M., Ozenci, V., Bergman, B., Egevad, L., Hellström, M., Kiessling, R., Masucci, G., Wersäll, P., Nilsson, S., and Pisa, P. (2004) A phase I trial of DNA vaccination with a plasmid expressing prostate-specific antigen in patients with hormone-refractory prostate cancer. Br. J. Cancer 91, 688-694
33. Chow, Y. H., Huang, W. L., Chi, W. K., Chu, Y. D., and Tao, M. H. (1997) Improvement of hepatitis B virus DNA vaccines by plasmids co-expressing hepatitis B surface antigen and interleukin-2. J. Virol. 71, 169-178
34. Li, W. R., Niu, B., Wang, J. W., Feng, Z. J., and Wang, D. X. (2006) Coexpression of interleukin-2 enhances the immunization effect of a DNA vaccine expressing herpes simplex 1 glycoprotein D. Acta Virol. 50, 251-256
35. Lin, C. C., Chou, C. W., Shiau, A. L., Tu, C. F., Ko, T. M., Chen, Y. L., Yang, B. C., Tao, M. H., and Lai, M. D. (2004) Therapeutic HER2/Neu DNA vaccine inhibits mouse tumor naturally over-expressing endogenous Neu. Mol. Ther. 10, 290-301
36. Klinman, D. M., Yamshchikov, G., and Ishigatsubo, Y. (1997) Contribution of CpG motifs to the immunogenicity of DNA vaccines. J. Immunol. 158, 3635-3639
37. Ulmer, J. B., DeWitt, C. M., Chastain, M., Friedman, A., Donnelly, J. J., McClements, W. L., Caulfield, M. J., Bohannon, K. E., Volkin, D. B., and Evans, R. K. (1999) Enhancement of DNA vaccine potency using conventional aluminum adjuvants. Vaccine 18, 18-28
38. Fischer, L., Minke, J., Dufay, N., Baudu, P., and Audonnet, J. C. (2003) Rabies DNA vaccine in the horse: strategies to improve serological responses. Vaccine 21, 4593-4596
39. Lin, B. C., White, R. G., Brown, K. K., Siedlik, L., Hrabik, C., and McGonigle, J. (2006) Ability of adjuvants to enhance the systemic antibody responses against H1N1 and H3N2 swine influenza viruses. AASV Swine Information CD-ROM Catalog 221-228, American Association of Swine Veterinarians, Perry, IA, USA
40. Finkelman, F. D., Holmes, J., Katona, I. M., Urban, J. F. Jr., Beckmann, M. P., Park, L. S., Schooley, K. A., Coffman, R. L., Mosmann, T. R., and Paul, W. E. (1990) Lymphokine control of in vivo immunoglobulin isotype selection. Annu. Rev. Immunol. 8, 303-333
41. Felgner, P. L. (1990) Particulate systems and polymers for in vitro and in vivo delivery of polynucleotides. Adv. Drug Deliv. Rev. 5, 163-187
42. Van Rooij, E. M. A., Glansbeek, H. L., Hilgers, L. A. T., te Lintelo, E. G., de Visser, Y. E., Boersma, W. J. A., Haagmans, B. L., and Bianchi, A. T. J. (2002) Protective antiviral immune responses to pseudorabies virus induced by DNA vaccination using dimethyldioctadecyl ammonium bromide as an adjuvant. J. Virol. 76, 10540-10545
43. Xiang, Z. Q., Spitalnik, S., Tran, M., Wunner, W. H., Cheng, J., and Ertl, H. C. (1994) Vaccination with a plasmid vector carrying the rabies virus glycoprotein gene induces protective immunity against rabies virus. Virology 199, 132-140
44. Bahloul, C., Ahmed, S. B. H., B'chir, B. I., Kharmachi, H., Hayouni, E. A., and Dellagi, K. (2003) Post-exposure therapy in mice against experimental rabies: a single injection of DNA vaccine is as effective as five injections of cell culture-derived vaccine. Vaccine 22, 177-184
45. Cruza, E. T., Feria-Romerob, I. A., López Mendoza, J. G., Orozcob, S. O., Hernández, R., Favela, F. B., Pérez Torres, A., and Aguilar Setién, J. A. (2008) Efficient post-exposure prophylaxis against rabies by applying a four-dose DNA vaccine intranasally. Vaccine 26, 6936-6944
46. Osorio, J. E., Tomlinson, C. C., Frank, R. S., Haanes, E. J., Rushlow, K., Haynes, J. R., and Stinchcomb, D. T. (1999) Immunization of dogs and cats with a DNA vaccine against rabies virus. Vaccine 17, 1109-1116
47. Patial, S., Chaturvedi, V. K., Rai, A., Saini, M., Chandra, R., Saini, Y., and Gupta, P. K. (2007) Virus neutralizing antibody response in mice and dogs with a bicistronic DNA vaccine encoding rabies virus glycoprotein and canine parvovirus VP2. Vaccine 25, 4020-4028
48. Lodmell, D. L., Parnell, M. J., Weyhrich, J. T., and Ewalt, L. C. (2003) Canine rabies DNA vaccination: a single-dose intradermal injection into ear pinnae elicits elevated and persistent levels of neutralizing antibody. Vaccine 21, 3998-4002