Clinical forms of canine visceral leishmaniasis in naturally Leishmania infantum-infected dogs and related myelogram and hemogram changes

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Nicolato, Roney De Carvalho ^a   De Abreu, Raquel Trópia ^a   Roatt, Bruno Mendes ^a   Aguiar Soares, Rodrigo Dian De Oliveira ^a   Reis, Levi Eduardo Soares ^a   Carvalho, Maria Das Graças ^b   Carneiro, Cláudia Martins ^a   Giunchetti, Rodolfo Cordeiro ^a,b   Bouillet, Leoneide Erica Maduro ^a   Lemos, Denise Silveira ^b   Coura Vital, Wendel ^a,b   Barbosa Reis, Alexandre ^a  

^a FEDERAL UNIVERSITY OF OURO PRETO   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN;

ANEMIA; ARTICLE; ASYMPTOMATIC INFECTION; BLOOD ANALYSIS; CELL LINEAGE; CONTROLLED STUDY; DISEASE ASSOCIATION; DOG; EOSINOPENIA; ERYTHROCYTE COUNT; FEMALE; HEMATOCRIT; HEMATOLOGICAL PARAMETERS; HEMATOPOIESIS; HEMOGLOBIN BLOOD LEVEL; LEISHMANIA INFANTUM; LEUKOCYTOSIS; LEUKOPENIA; LYMPHOCYTOPENIA; LYMPHOCYTOSIS; MALE; MONOCYTOPENIA; MYELOGRAPHY; NONHUMAN; PATHOGENESIS; POLYMERASE CHAIN REACTION; PROGNOSIS; VISCERAL LEISHMANIASIS;

ANIMALS; ASYMPTOMATIC DISEASES; BLOOD CELL COUNT; BONE MARROW; DOG DISEASES; DOGS; ERYTHROPOIESIS; FEMALE; LEISHMANIA INFANTUM; LEISHMANIASIS, VISCERAL; LEUKOPENIA; LEUKOPOIESIS; MALE; SEVERITY OF ILLNESS INDEX; SKIN;

EID: 84893511873     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0082947     Document Type: Article

References (39)

1. Nunes CM, Pires MM, da Silva KM, Assis FD, Goncalves Filho J, et al. (2010) Relationship between dog culling and incidence of human visceral leishmaniasis in an endemic area. Vet Parasitol 170: 131-133.
2. Coura-Vital W, Marques MJ, Veloso VM, Roatt BM, Aguiar-Soares RD, et al. (2011) Prevalence and factors associated with Leishmania infantum infection of dogs from an urban area of Brazil as identified by molecular methods. PLoS Negl Trop Dis 5: e1291.
3. Giunchetti RC, Mayrink W, Genaro O, Carneiro CM, Correa-Oliveira R, et al. (2006) Relationship between canine visceral leishmaniosis and the Leishmania (Leishmania) chagasi burden in dermal inflammatory foci. J Comp Pathol 135: 100-107. (Pubitemid 44417993)
4. Coura-Vital W, Reis AB, Fausto MA, Leal GGdA, Marques MJ, et al. (2013) Risk Factors for Seroconversion by Leishmania infantum in a Cohort of Dogs from an Endemic Area of Brazil. PLoS One 8: e71833.
5. Coura-Vital W, Reis AB, Reis LE, Braga SL, Roatt BM, et al. (2013) Canine visceral leishmaniasis: Incidence and risk factors for infection in a cohort study in Brazil. Vet Parasitol In press.
6. Ciaramella P, Oliva G, Luna RD, Gradoni L, Ambrosio R, et al. (1997) A retrospective clinical study of canine leishmaniasis in 150 dogs naturally infected by Leishmania infantum. Vet Rec 141: 539-543. (Pubitemid 127492601)
7. Reis AB, Martins-Filho OA, Teixeira-Carvalho A, Giunchetti RC, Carneiro CM, et al. (2009) Systemic and compartmentalized immune response in canine visceral leishmaniasis. Vet Immunol Immunopathol 128: 87-95.
8. Pinelli E, Killick-Kendrick R, Wagenaar J, Bernadina W, del Real G, et al. (1994) Cellular and humoral immune responses in dogs experimentally and naturally infected with Leishmania infantum. Infect Immun 62: 229-235. (Pubitemid 24011964)
9. Reis AB, Teixeira-Carvalho A, Giunchetti RC, Guerra LL, Carvalho MG, et al. (2006) Phenotypic features of circulating leucocytes as immunological markers for clinical status and bone marrow parasite density in dogs naturally infected by Leishmania chagasi. Clin Exp Immunol 146: 303-311. (Pubitemid 44581346)
10. Reis AB, Teixeira-Carvalho A, Vale AM, Marques MJ, Giunchetti RC, et al. (2006) Isotype patterns of immunoglobulins: hallmarks for clinical status and tissue parasite density in Brazilian dogs naturally infected by Leishmania (Leishmania) chagasi. Vet Immunol Immunopathol 112: 102-116. (Pubitemid 44040860)
11. Tropia de Abreu R, Carvalho MG, Carneiro CM, Giunchetti RC, Teixeira-Carvalho A, et al. (2011) Influence of clinical status and parasite load on erythropoiesis and leucopoiesis in dogs naturally infected with Leishmania (Leishmania) chagasi. PLoS One 6: e18873.
12. da Costa-Val AP, Cavalcanti RR, de Figueiredo Gontijo N, Michalick MS, Alexander B, et al. (2007) Canine visceral leishmaniasis: relationships between clinical status, humoral immune response, haematology and Lutzomyia (Lutzomyia) longipalpis infectivity. Vet J 174: 636-643. (Pubitemid 350082709)
13. Diebold J, Molina T, Camilleri-Broet S, Le Tourneau A, Audouin J (2000) Bone marrow manifestations of infections and systemic diseases observed in bone marrow trephine biopsy review. Histopathology 37: 199-211.
14. Weiss DJ (2006) A retrospective study of the incidence and the classification of bone marrow disorders in the dog at a veterinary teaching hospital (1996-2004). J Vet Intern Med 20: 955-961.
15. Elmore SA (2006) Enhanced histopathology of the bone marrow. Toxicol Pathol 34: 666-686.
16. Travlos GS (2006) Normal structure, function, and histology of the bone marrow. Toxicol Pathol 34: 548-565.
17. Foglia Manzillo V, Di Muccio T, Cappiello S, Scalone A, Paparcone R, et al. (2013) Prospective study on the incidence and progression of clinical signs in naive dogs naturally infected by Leishmania infantum. PLoS Negl Trop Dis 7: e2225.
18. Coura-Vital W, Marques MJ, Giunchetti RC, Teixeira-Carvalho A, Moreira ND, et al. (2011) Humoral and cellular immune responses in dogs with inapparent natural Leishmania infantum infection. Vet J 190: e43-47.
19. Degrave W, Fernandes O, Campbell D, Bozza M, Lopes U (1994) Use of molecular probes and PCR for detection and typing of Leishmania - a mini-review. Mem Inst Oswaldo Cruz 89: 463-469.
20. Volpini AC, Passos VM, Oliveira GC, Romanha AJ (2004) PCR-RFLP to identify Leishmania (Viannia) braziliensis and L. (Leishmania) amazonensis causing American cutaneous leishmaniasis. Acta Trop 90: 31-37. (Pubitemid 38117054)
21. Penny RH (1974) The bone marrow of the dog and cat. J Small Anim Pract 15: 553-562.
22. Jain NC (1986) Schalm's Veterinary Hematology, 4th edn. Lea & Febiger, Philadelphia, p. 8-18.
23. Keenan CM, Hendricks LD, Lightner L, Webster HK, Johnson AJ (1984) Visceral leishmaniasis in the German shepherd dog. I. Infection, clinical disease, and clinical pathology. Vet Pathol 21: 74-79.
24. Abranches P, Santos-Gomes G, Rachamim N, Campino L, Schnur LF, et al. (1991) An experimental model for canine visceral leishmaniasis. Parasite Immunol 13: 537-550.
25. Koutinas AF, Polizopoulou ZS, Saridomichelakis MN, Argyriadis D, Fytianou A, et al. (1999) Clinical considerations on canine visceral leishmaniasis in Greece: a retrospective study of 158 cases (1989-1996). J Am Anim Hosp Assoc 35: 376-383. (Pubitemid 129566798)
26. Reis AB, Martins-Filho OA, Teixeira-Carvalho A, Carvalho MG, Mayrink W, et al. (2006) Parasite density and impaired biochemical/hematological status are associated with severe clinical aspects of canine visceral leishmaniasis. Res Vet Sci 81: 68-75. (Pubitemid 43323779)
27. Saeed AM, Khalil EA, Elhassan AM, Hashim FA, Fandrey J, et al. (1998) Serum erythropoietin concentration in anaemia of visceral leishmaniasis (kala-azar) before and during antimonial therapy. Br J Haematol 100: 720-724. (Pubitemid 28126105)
28. Pippard MJ, Moir D, Weatherall DJ, Lenicker HM (1986) Mechanism of anaemia in resistant visceral leishmaniasis. Ann Trop Med Parasitol 80: 317-323. (Pubitemid 16065515)
29. De Luna R, Ferrante M, Severino L, Ambrosio R, Piantedosi D, et al. (2000) Decreased lipid fluidity of the erythrocyte membrane in dogs with leishmaniasis-associated anaemia. J Comp Pathol 122: 213-216. (Pubitemid 30301561)
30. Amusategui I, Sainz A, Rodriguez F, Tesouro MA (2003) Distribution and relationships between clinical and biopathological parameters in canine leishmaniasis. Eur J Epidemiol 18: 147-156. (Pubitemid 36460115)
31. Barrouin-Melo SM, Larangeira DF, de Andrade Filho FA, Trigo J, Juliao FS, et al. (2006) Can spleen aspirations be safely used for the parasitological diagnosis of canine visceral leishmaniosis? A study on assymptomatic and polysymptomatic animals. Vet J 171: 331-339. (Pubitemid 43257237)
32. Tryphonas L, Zawidzka Z, Bernard MA, Janzen EA (1977) Visceral leishmaniasis in a dog: clinical, hematological and pathological observations. Can J Comp Med 41: 1-12. (Pubitemid 8037062)
33. Bourdoiseau G, Bonnefont C, Magnol JP, Saint-Andre I, Chabanne L (1997) Lymphocyte subset abnormalities in canine leishmaniasis. Vet Immunol Immunopathol 56: 345-351. (Pubitemid 27288161)
34. Vercosa BL, Lemos CM, Mendonca IL, Silva SM, de Carvalho SM, et al. (2008) Transmission potential, skin inflammatory response, and parasitism of symptomatic and asymptomatic dogs with visceral leishmaniasis. BMC Vet Res 4: 45.
35. Guerra LL, Teixeira-Carvalho A, Giunchetti RC, Martins-Filho OA, Reis AB, et al. (2009) Evaluation of the influence of tissue parasite density on hematological and phenotypic cellular parameters of circulating leukocytes and splenocytes during ongoing canine visceral leishmaniasis. Parasitol Res 104: 611-622.
36. Foglia Manzillo V, Restucci B, Pagano A, Gradoni L, Oliva G (2006) Pathological changes in the bone marrow of dogs with leishmaniosis. Vet Rec 158: 690-694. (Pubitemid 43826822)
37. Cashell AW, Buss DH (1992) The frequency and significance of megakaryocytic emperipolesis in myeloproliferative and reactive states. Ann Hematol 64: 273-276.
38. Lee KP (1989) Emperipolesis of hematopoietic cells within megakaryocytes in bone marrow of the rat. Vet Pathol 26: 473-478.
39. Anosa VO, Idowu AL (1983) The clinico-haematological features and pathology of leishmaniasis in a dog in Nigeria. Zentralbl Veterinarmed B 30: 600-608.