Serum biochemical responses under oxidative stress of aspartame in wistar albino rats

Asian Pacific Journal of Tropical Disease

Volumn 4, Issue S1, 2014, Pages

  Choudhary, Arbind Kumar ^a   Devi, Rathinasamy Sheela ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Antioxidant; Aspartame; Marker enzymes; Oxidative stress; Serum

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTAME; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CALCIUM; CORTICOSTERONE; CREATININE; FORMIMINOGLUTAMIC ACID; GLUCOSE; GLUTATHIONE PEROXIDASE; HEMOGLOBIN; LACTATE DEHYDROGENASE; NITRIC OXIDE; SODIUM; SUPEROXIDE DISMUTASE; UREA; URIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BLEEDING TIME; BLOOD CLOTTING TIME; BLOOD SAMPLING; BODY WEIGHT; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; ENZYME ACTIVITY; EOSINOPHIL COUNT; ERYTHROCYTE COUNT; ERYTHROCYTE SEDIMENTATION RATE; FOLIC ACID DEFICIENCY; HEMATOCRIT; HEMATOLOGICAL PARAMETERS; KIDNEY FUNCTION; LIPID PEROXIDATION; LIVER FUNCTION; MALE; MEAN CORPUSCULAR HEMOGLOBIN; MEAN CORPUSCULAR VOLUME; MONOCYTE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; RETICULOCYTE COUNT; THROMBOCYTE COUNT; URINARY EXCRETION;

EID: 84893511295     PISSN: 22221808     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2222-1808(14)60478-3     Document Type: Article

References (45)

1. Oppermann JA Aspartame metabolism in animals. Aspartame, physiology and biochemistry 1984, 141-159. Marcel Dekker Inc., New York. L.D. Stegink, L.J. Filer (Eds.).
2. Parthasarathy NJ, Kumar RS, Manikandan S, Devi RS Methanol-induced oxidative stress in rat lymphoid organs. J Occup Health 2006, 48(1):20-27.
3. Castro GD, Costantini MH, Delgado de layno AM, Castro JA Rat liver microsomal and nuclear activation of methanol to hydroxyl methyl free radicals. Toxicol Lett 2002, 129(3):227-236.
4. Stegink LD, Brummel MC, McMartin K, Martin-Amat G, Filer LJ, Baker GL, et al. Blood methanol concentrations in normal adult subjects administered abuse doses of aspartame. J Toxicol Environ Health 1981, 7:281-290.
5. Malomo SO Toxicological implication of ceftriaxone administration in rats. Nig J Biochem Mol Biol 2000, 15(1):33-38.
6. Yakubu MT, Bilbis LS, Lawal M, Akanji MA Effect of repeated administration of sildenafil citrate on selected enzyme activities of liver and kidney of male albino rats. Nig J Pure Appl Sci 2003, 18:1395-1400.
7. Zanna H, Adeniji S, Shehu BB, Modu S, Ishaq GM Effect of aqueous suspension of the root of Hyphaene thebaica (L) mart on some indicators of liver and kidney function in rats. J Pharmacol Toxicol 2008, 3:330-333.
8. Atangwho IJ, Ebong PE, Eteng MU, Eyong EU, Obi AU Effect of Vernonia amygdalina Del leaf on kidney function of diabetic rats. Int J Pharmacol 2007, 3:143-148.
9. Uboh FE, Akpanabiatu MI, Ndem JI, Alozie Y, Ebong PE Comparative nephrotoxic effect associated with exposure to diesel and gasoline vapours in rats. J Toxicol Environ Health Sci 2009, 1:68-74.
10. Sies H Oxidative stress: Oxidants and antioxidants. Exp Physiol 1997, 82(2):291-295.
11. Walzem RL, Clifford AJ Folate defiency in rats fed diets containing free aminoacid or intact proteins. J Nutr 1988, 118:1089-1096.
12. Hwang MS, Meadows CA, Thenen SW Methotrexate effect on folate status and the deoxyuridine suppression test in rats. Nutr Res 1989, 9(4):431-444.
13. Rabinowitz JC, Pricer WE Formiminotetrahydrofolic acid and methenyltetrahydrofolic acid as intermediates in the formation of N10-formyltetrahydrofolic acid. J Am Chem Soc 1956, 78(21):5702-5704.
14. European Food Safety Authority (EFSA) Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to a new long-term carcinogenicity study on aspartame. EFSA J 2006, 4(5):1-44.
15. Maker AB, Tephly TR Methanol poisoning in the folate-deficient rats. Nature 1976, 261:715-716.
16. Tephly TR The toxicity of methanol. Life Sci 1991, 48:1031-1041.
17. Feldman S, Conforti N Participation of the dorsal hippocampus in the glucocorticoids feedback effect on adrenocortical activity. Neuroendocrinology 1980, 30:52-55.
18. Bradford MM A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254.
19. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ Protein measurement with the Folin phenol reagent. J Biol Chem 1951, 193:265-275.
20. King J The transferases alanine and aspartate tranaminases. Practical clinical enzymology 1965, 121-138. Van Nostrand Company Limited, London.
21. Orlowski M, Meister A Isolation of gamma-glutamyl transpeptidase from hog kidney. J Biol Chem 1965, 240:338-347.
22. Ohkawa H, Ohishi N, Yagi K Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979, 95:351-358.
23. Marklund S, Marklund G Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 1974, 47:469-474.
24. Sinha AK Colorimetric assay of catalase. Anal Biochem 1972, 47:389-394.
25. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG Selenium: biochemical role as a component of glutathione peroxidase. Science 1973, 179:588-590.
26. Moron MS, Difieree JW, Mannervik B Levels of glutathione, reductase and glutathione-S-transferase activities in rat lung and liver. Biochem Biophys Acta 1979, 582:67-68.
27. Omaye ST, Turnbull JD, Sauberlich HE Selected methods for the determination of ascorbic acid in animal cells, tissues and fluids. Methods Enzymol 1979, 62:3-11.
28. Pagana KD, Pagana TJ Mosby's manual of diagnostic and laboratory tests 2002, 1-44. Mosby, St Louis, Missouri USA. 2nd ed.
29. Mayne PD Plasma enzymes in diagnosis. Clinical chemistry in diagnosis and treatment 1994, 303-307. Arnold Publishers, London. 6th ed.
30. Britton KT, Segal DS, Kuczenski R, Havger R Dissociation between in vivo hippocampal norepinephrine response and behavioral neuro endocrine responses to noise stress in rats. Brain Res 1992, 574:125-130.
31. Dhabhar FS, McEwen BS Acute stress enhances while chronic stress suppress cell-mediated immunity in vivo: a potential role for leukocyte trafficking. Brain Behav Immun 1997, 11:286-306.
32. Seyle H The physiology and pathology of exposure to stress 1950, Acta Inc., Montreal, Canada.
33. Berner MD, Sura ME, Alves BN, Hunter KW IFN-γ primes macrophages for enhanced TNF-α expression in response to stimulatory and non-stimulatory amount of microparticulate β-glucan. Immunol Lett 2005, 98:115-122.
34. Matsumoto K, Yobimoto K, Huong NT, Abdel-Fattah M, Van Hien, Watanabe H Psychological stress-induced enhancement of brain lipid peroxidation via nitric oxide systems and its modulation by anxiolytic and anxiogenic drugs in mice. Brain Res 1999, 839:74-84.
35. Zararsiz I, Sarsilmaz M, Tas U, Kus I, Meydan S, Ozan E Protective effect of melatonin against formaldehyde-induced kidney damage in rats. Toxicol Ind Health 2007, 23(10):573-579.
36. Murray RK, Granner DK, Mayes PA, Rodwell VW Harper's illustrated biochemistry 2003, McGraw-Hill Companies Inc., New York. 26 ed.
37. Bhattacharjee R, Sil PC The protein fraction of Phyllanthus niruri plays a protective role against acetaminophen induced hepatic disorder via its antioxidant properties. Phytother Res 2006, 20:595-601.
38. Vidyasagar J, Karunakar N, Reddy MS, Rajnarayana K, Surender T, Krishna DR Oxidative stress and antioxidant status in acute organophosphorous insecticide poisoning. Indian J Pharmacol 2004, 36:76-79.
39. Pigeolet E, Corbisler P, Houbion A, Lambert D, Mitchiels C, Raes M, et al. Glutathione peroxidase, superoxide dismutase, and catalase inactivation by peroxides and oxygen derived free radicals. Mech Ageing Dev 1990, 51:283-297.
40. Gulec M, Gurel A, Armutcu F Vitamin E protects against oxidative damage caused by formaldehyde in the liver and plasma of rats. Mol Cell Biochem 2006, 290(1-2):61-67.
41. Chang JR, Xu DQ Effects of formaldehyde on the activity of superoxide dismutase and glutathione peroxidase and the concentration of malondialdehyde. Wei Sheng Yan Jiu 2006, 35(5):653-655.
42. Oyama Y, Sakai H, Arata T, Okano Y, Akaike N, Sakai K, et al. Cytotoxic effects of methanol, formaldehyde and formate on dissociated rat thymocytes: A possibility of aspartame toxicity. Cell Biol Toxicol 2002, 18(1):43-50.
43. Briviba K, Sies H Nonenzymatic antioxidant defense systems. Natural antioxidants in human health and disease 1994, 107-128. Academic Press, San Diego. B. Frei (Ed.).
44. Skrzydlewksa E, Szynaka B Ultrastructural elevation of lysosome and biochemical change in cathepsin D distribution in hepatocytes in methanol intoxication. Rocz Akad Med Bialymst 1997, 42:47-55.
45. Nakao H, Umebayashi C, Nakata M, Nishizaki Y, Noda K, Okanao Y, et al. Formaldehyde induced shrinkage of rat thymocyte. J Pharmacol Sci 2003, 91:83-86.