Particle-based transcutaneous administration of HIV-1 p24 protein to human skin explants and targeting of epidermal antigen presenting cells

Journal of Controlled Release

Volumn 176, Issue 1, 2014, Pages 115-122

  Rancan, Fiorenza ^a   Amselgruber, Sarah ^a   Hadam, Sabrina ^a   Munier, Sevérine ^b   Pavot, Vincent ^b   Verrier, Bernard ^b   Hackbarth, Steffen ^c   Combadiere, Behazine ^d   Blume Peytavi, Ulrike ^a   Vogt, Annika ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITÉ DE LYON   (France)

^c HUMBOLDT UNIVERSITY   (Germany)

^d SORBONNE UNIVERSITÉ   (France)

Author keywords

Cyanoacrylate stripping; DC activation; Langerhans cells; Poly lactic acid; Transcutaneous vaccination

Indexed keywords

ANTIGENS; CELLS; CHEMICAL ACTIVATION; CYTOLOGY; LACTIC ACID; PROTEINS; VACCINES;

ANTIGEN PRESENTING CELLS; CYANOACRYLATES; EFFECTIVE APPROACHES; LANGERHANS CELLS; POLY LACTIC ACID; TRANSCUTANEOUS IMMUNIZATIONS; TRANSCUTANEOUS VACCINATIONS; VACCINATION STRATEGY;

DISEASES;

HUMAN IMMUNODEFICIENCY VIRUS 1 P24 PROTEIN; LACTIC ACID; POLYSTYRENE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANTIGEN PRESENTING CELL; ARTICLE; CELL ACTIVATION; CELL MATURATION; CONTROLLED STUDY; CYANOACRYLATE SKIN SURFACE STRIPPING; DENDRITIC CELL; DERMIS; DRUG DELIVERY SYSTEM; DRUG TARGETING; EPIDERMIS; EPIDERMIS CELL; EXPLANT; HAIR FOLLICLE; HUMAN; HUMAN CELL; LANGERHANS CELL; PRIORITY JOURNAL; SKIN CELL; SKIN EXAMINATION; SUSTAINED DRUG RELEASE;

CYANOACRYLATE STRIPPING; DC ACTIVATION; LANGERHANS CELLS; POLY-LACTIC ACID; TRANSCUTANEOUS VACCINATION;

ADMINISTRATION, CUTANEOUS; ANTIGEN-PRESENTING CELLS; CYANOACRYLATES; DRUG CARRIERS; HAIR FOLLICLE; HIV CORE PROTEIN P24; HUMANS; LACTIC ACID; POLYMERS; POLYSTYRENES; SKIN;

EID: 84893509394     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.12.022     Document Type: Article

References (41)

1. G.M. Glenn, and R.T. Kenney Mass vaccination: solutions in the skin Curr. Top. Microbiol. Immunol. 304 2006 247 268 (Pubitemid 47413300)
2. B. Combadiere, and C. Liard Transcutaneous and intradermal vaccination Hum. Vaccin. 7 2011 811 827
3. R.C. Seid Jr., J.L. Look, C. Ruiz, V. Frolov, D. Flyer, J. Schafer, and L. Ellingsworth Transcutaneous immunization with Intercell's vaccine delivery system Vaccine 30 2012 4349 4354
4. M.B. Teunissen, M. Haniffa, and M.P. Collin Insight into the immunobiology of human skin and functional specialization of skin dendritic cell subsets to innovate intradermal vaccination design Curr. Top. Microbiol. Immunol. 351 2012 25 76
5. J. Valladeau, and S. Saeland Cutaneous dendritic cells Semin. Immunol. 17 2005 273 283 (Pubitemid 40984021)
6. M.Y. Lee, M.C. Shin, and V.C. Yang Transcutaneous antigen delivery system BMB Rep. 46 2013 17 24
7. G. Eisenberg, A. Machlenkin, S. Frankenburg, A. Mansura, J. Pitcovski, E. Yefenof, T. Peretz, and M. Lotem Transcutaneous immunization with hydrophilic recombinant gp100 protein induces antigen-specific cellular immune response Cell. Immunol. 266 2010 98 103
8. C. Liard, S. Munier, M. Arias, A. Joulin-Giet, O. Bonduelle, D. Duffy, R.J. Shattock, B. Verrier, and B. Combadiere Targeting of HIV-p24 particle-based vaccine into differential skin layers induces distinct arms of the immune responses Vaccine 29 2011 6379 6391
9. N. Romani, M. Thurnher, J. Idoyaga, R.M. Steinman, and V. Flacher Targeting of antigens to skin dendritic cells: possibilities to enhance vaccine efficacy Immunol. Cell Biol. 88 2010 424 430
10. S.M. Bal, A.C. Kruithof, R. Zwier, E. Dietz, J.A. Bouwstra, J. Lademann, and M.C. Meinke Influence of microneedle shape on the transport of a fluorescent dye into human skin in vivo J. Control. Release 147 2010 218 224
11. R. Toll, U. Jacobi, H. Richter, J. Lademann, H. Schaefer, and U. Blume-Peytavi Penetration profile of microspheres in follicular targeting of terminal hair follicles J. Invest. Dermatol. 123 2004 168 176 (Pubitemid 38833478)
12. A. Vogt, B. Mahe, D. Costagliola, O. Bonduelle, S. Hadam, G. Schaefer, H. Schaefer, C. Katlama, W. Sterry, B. Autran, U. Blume-Peytavi, and B. Combadiere Transcutaneous anti-influenza vaccination promotes both CD4 and CD8 T cell immune responses in humans J. Immunol. 180 2008 1482 1489
13. B. Combadiere, A. Vogt, B. Mahe, D. Costagliola, S. Hadam, O. Bonduelle, W. Sterry, S. Staszewski, H. Schaefer, S. van der Werf, C. Katlama, B. Autran, and U. Blume-Peytavi Preferential amplification of CD8 effector-T cells after transcutaneous application of an inactivated influenza vaccine: a randomized phase I trial PLoS ONE 5 2010 e10818
14. O.H. Mills Jr., and A.M. Kligman The follicular biopsy Dermatologica 167 1983 57 63 (Pubitemid 13036798)
15. H. Schaefer, and J. Lademann The role of follicular penetration. A differential view Skin Pharmacol. Appl. Ski. Physiol. 14 Suppl. 1 2001 23 27 (Pubitemid 34299160)
16. J. Lademann, H. Richter, U.F. Schaefer, U. Blume-Peytavi, A. Teichmann, N. Otberg, and W. Sterry Hair follicles - a long-term reservoir for drug delivery Skin Pharmacol. Appl. Ski. Physiol. 19 2006 232 236 (Pubitemid 44114522)
17. A. Kubo, K. Nagao, M. Yokouchi, H. Sasaki, and M. Amagai External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers J. Exp. Med. 206 2009 2937 2946
18. R. Alvarez-Roman, A. Naik, Y.N. Kalia, R.H. Guy, and H. Fessi Skin penetration and distribution of polymeric nanoparticles J. Control. Release 99 2004 53 62 (Pubitemid 39165733)
19. J. Lademann, H. Richter, A. Teichmann, N. Otberg, U. Blume-Peytavi, J. Luengo, B. Weiss, U.F. Schaefer, C.M. Lehr, R. Wepf, and W. Sterry Nanoparticles-an efficient carrier for drug delivery into the hair follicles Eur. J. Pharm. Biopharm. 66 2007 159 164 (Pubitemid 46654773)
20. F. Rancan, A. Todorova, S. Hadam, D. Papakostas, E. Luciani, C. Graf, U. Gernert, E. Ruhl, B. Verrier, W. Sterry, U. Blume-Peytavi, and A. Vogt Stability of polylactic acid particles and release of fluorochromes upon topical application on human skin explants Eur. J. Pharm. Biopharm. 80 2012 76 84
21. A. Vogt, N. Mandt, J. Lademann, H. Schaefer, and U. Blume-Peytavi Follicular targeting-a promising tool in selective dermatotherapy J. Investig. Dermatol. Symp. Proc. 10 2005 252 255
22. A. Mittal, A.S. Raber, U.F. Schaefer, S. Weissmann, T. Ebensen, K. Schulze, C.A. Guzman, C.M. Lehr, and S. Hansen Non-invasive delivery of nanoparticles to hair follicles: a perspective for transcutaneous immunization Vaccine 31 2013 3442 3451
23. R.B. Baleeiro, K.H. Wiesmuller, Y. Reiter, B. Baude, L. Dahne, A. Patzelt, J. Lademann, J.A. Barbuto, and P. Walden Topical vaccination with functionalized particles targeting dendritic cells J. Investig. Dermatol. 2013 10.1038/jid.2013.79
24. A. Vogt, B. Combadiere, S. Hadam, K.M. Stieler, J. Lademann, H. Schaefer, B. Autran, W. Sterry, and U. Blume-Peytavi 40 nm, but not 750 or 1,500 nm, nanoparticles enter epidermal CD1a + cells after transcutaneous application on human skin J. Investig. Dermatol. 126 2006 1316 1322 (Pubitemid 43997914)
25. B. Mahe, A. Vogt, C. Liard, D. Duffy, V. Abadie, O. Bonduelle, A. Boissonnas, W. Sterry, B. Verrier, U. Blume-Peytavi, and B. Combadiere Nanoparticle-based targeting of vaccine compounds to skin antigen-presenting cells by hair follicles and their transport in mice J. Investig. Dermatol. 129 2009 1156 1164
26. F. Rancan, Q. Gao, C. Graf, S. Troppens, S. Hadam, S. Hackbarth, C. Kembuan, U. Blume-Peytavi, E. Ruhl, J. Lademann, and A. Vogt Skin Penetration and Cellular Uptake of Amorphous Silica Nanoparticles with Variable Size, Surface Functionalization, and Colloidal Stability ACS Nano 6 2012 6829 6842
27. C. Guillon, K. Mayol, C. Terrat, C. Compagnon, C. Primard, M.H. Charles, T. Delair, S. Munier, and B. Verrier Formulation of HIV-1 Tat and p24 antigens by PLA nanoparticles or MF59 impacts the breadth, but not the magnitude, of serum and faecal antibody responses in rabbits Vaccine 25 2007 7491 7501 (Pubitemid 47516619)
28. Y. Ataman-Onal, S. Munier, A. Ganee, C. Terrat, P.Y. Durand, N. Battail, F. Martinon, R. Le Grand, M.H. Charles, T. Delair, and B. Verrier Surfactant-free anionic PLA nanoparticles coated with HIV-1 p24 protein induced enhanced cellular and humoral immune responses in various animal models J. Control. Release 112 2006 175 185
29. G. Mattheolabakis, G. Lagoumintzis, Z. Panagi, E. Papadimitriou, C.D. Partidos, and K. Avgoustakis Transcutaneous delivery of a nanoencapsulated antigen: induction of immune responses Int. J. Pharm. 385 2010 187 193
30. C. Liard, S. Munier, A. Joulin-Giet, O. Bonduelle, S. Hadam, D. Duffy, A. Vogt, B. Verrier, and B. Combadiere Intradermal immunization triggers epidermal Langerhans cell mobilization required for CD8 T-cell immune responses J. Investig. Dermatol. 132 2012 615 625
31. D. Lamalle-Bernard, S. Munier, C. Compagnon, M.H. Charles, V.S. Kalyanaraman, T. Delair, B. Verrier, and Y. Ataman-Onal Coadsorption of HIV-1 p24 and gp120 proteins to surfactant-free anionic PLA nanoparticles preserves antigenicity and immunogenicity J. Control. Release 115 2006 57 67 (Pubitemid 44429985)
32. A. Sze, D. Erickson, L. Ren, and D. Li Zeta-potential measurement using the Smoluchowski equation and the slope of the current-time relationship in electroosmotic flow J. Colloid Interface Sci. 261 2003 402 410 (Pubitemid 36535454)
33. F. Rancan, D. Papakostas, S. Hadam, S. Hackbarth, T. Delair, C. Primard, B. Verrier, W. Sterry, U. Blume-Peytavi, and A. Vogt Investigation of polylactic acid (PLA) nanoparticles as drug delivery systems for local dermatotherapy Pharm. Res. 26 2009 2027 2036
34. A. Vogt, S. Hadam, M. Heiderhoff, H. Audring, J. Lademann, W. Sterry, and U. Blume-Peytavi Morphometry of human terminal and vellus hair follicles Exp. Dermatol. 16 2007 946 950 (Pubitemid 47570635)
35. T.W. Prow, J.E. Grice, L.L. Lin, R. Faye, M. Butler, W. Becker, E.M. Wurm, C. Yoong, T.A. Robertson, H.P. Soyer, and M.S. Roberts Nanoparticles and microparticles for skin drug delivery Adv. Drug Deliv. Rev. 63 2011 470 491
36. J. Panyam, and V. Labhasetwar Dynamics of endocytosis and exocytosis of poly(D, L-lactide-co-glycolide) nanoparticles in vascular smooth muscle cells Pharm. Res. 20 2003 212 220 (Pubitemid 36277684)
37. J.D. Bos, and M.M. Meinardi The 500 Dalton rule for the skin penetration of chemical compounds and drugs Exp. Dermatol. 9 2000 165 169 (Pubitemid 30255378)
38. C.D. Partidos, and S. Muller Decision-making at the surface of the intact or barrier disrupted skin: potential applications for vaccination or therapy Cell. Mol. Life Sci. 62 2005 1418 1424 (Pubitemid 40922945)
39. S. Yan, W. Gu, and Z.P. Xu Re-considering how particle size and other properties of antigen-adjuvant complexes impact on the immune responses J. Colloid Interface Sci. 395 2013 1 10
40. M. Pearton, D. Pirri, S.M. Kang, R.W. Compans, and J.C. Birchall Host Responses in Human Skin After Conventional Intradermal Injection or Microneedle Administration of Virus-Like-Particle Influenza Vaccine Adv. Healthc. Mater. 2 2013 1401 1410
41. D. Duffy, H. Perrin, V. Abadie, N. Benhabiles, A. Boissonnas, C. Liard, B. Descours, D. Reboulleau, O. Bonduelle, B. Verrier, N. Van Rooijen, C. Combadiere, and B. Combadiere Neutrophils transport antigen from the dermis to the bone marrow, initiating a source of memory CD8 + T cells Immunity 37 2012 917 929