The active site sulfenic acid ligand in nitrile hydratases can function as a nucleophile

Journal of the American Chemical Society

Volumn 136, Issue 4, 2014, Pages 1186-1189

  Martinez, Salette ^a,b   Wu, Rui ^b   Sanishvili, Ruslan ^c   Liu, Dali ^b   Holz, Richard ^a  

^a Marquette University   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

^c ARGONNE NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC NUCLEOPHILES; HYDROLYTIC ENZYME; NITRILE HYDRATASES; PHENYLBORONIC ACIDS; PHYSIOLOGICAL PH; POTENT INHIBITOR; REACTION MECHANISM; X RAY CRYSTAL STRUCTURES;

AMINO ACIDS; HYDRATION; LIGANDS; NUCLEOPHILES; PH; X RAY CRYSTALLOGRAPHY;

CYANIDES;

BORONIC ACID DERIVATIVE; CYSTEINE; HYDROLASE; LIGAND; LIQUID NITROGEN; NITRILE HYDRATASE; NUCLEOPHILE; SULFENIC ACID DERIVATIVE;

ARTICLE; ATOMIC EMISSION SPECTROMETRY; CATALYSIS; COVALENT BOND; CRYSTAL STRUCTURE; ENVIRONMENTAL TEMPERATURE; ENZYME ACTIVE SITE; HYDRATION; NONHUMAN; NUCLEOPHILICITY; PH; PROTON TRANSPORT; PSEUDONOCARDIA THERMOPHILA; PSEUDONOCARDIACEAE; REACTION ANALYSIS; X RAY ANALYSIS; X RAY CRYSTALLOGRAPHY;

ACTINOBACTERIA; BIOCATALYSIS; BORON COMPOUNDS; BORONIC ACIDS; CATALYTIC DOMAIN; ENZYME INHIBITORS; HYDRO-LYASES; LIGANDS; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; SULFENIC ACIDS;

EID: 84893468287     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja410462j     Document Type: Article

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