Pathophysiology of merkel cell

Journal of Oral and Maxillofacial Pathology

Volumn 17, Issue 3, 2013, Pages 408-412

  Munde, Prashant Balasaheb ^a   Khandekar, Shubhangi P ^a   Dive, Alka M ^a   Sharma, Aparna ^a  

^a Vidya Shikshan Prasarak Mandals Dental College and Research Centre   (India)

Author keywords

Cytokeratin 20; Merkel cell carcinoma; Merkel cells

Indexed keywords

EID: 84893434744     PISSN: 0973029X     EISSN: 1998393X     Source Type: Journal    
DOI: 10.4103/0973-029X.125208     Document Type: Review

References (33)

1. Tachibana T. The Merkel cell: Recent findings and unresolved problems. Arch Histol Cytol 1995;58:379-96.
2. Tweedle CD. Ultrastructure of Merkel cell development in aneurogenic and control amphibian larvae (ambystoma). Neuroscience 1978;3:481-6.
3. Moll I, Lane AT, Franke WW, Moll R. Intra epidermal formation of Merkel cell in xenografts of human foetal skin. J Invest Dermatol 1990;94:359-64.
4. Grim M, Halata Z. Developmental origin of avian Merkel cell. Anat Embryol (Berl) 2000;202:401-10.
5. Halata Z, Grim M, Christ B. Origin of spinal cord meninges sheaths of peripheral nerves, and cutaneous receptors including Merkel cell. An experimental and ultrastructural study with avian chimeras. Anat Embryol (Berl) 1990;182:529-37.
6. Gollard R, Weber R, Kosty MP, Greenway HT, Massullo V, Humberson C. Merkel cell carcinoma: Review of 22 cases with surgical, pathologic, and therapeutic considerations. Cancer 2000;88:1842-51.
7. Halata Z, Gim M, Baumann KI. Friedrich sigmund Merkel and his "Merkel cell", morphology, development and physiology: Review and new results. Anat Rec A Discov Mol Cell Evol Biol 2003;271:225-39.
8. Moll I, Roessler M, Brandner JM, Eispert AC, Houdek P, Moll R. Human Merkel cells-Aspects of cell biology, distribution and functions. Eur J Cell Biol 2005;84:259-71.
9. Hartschuh W, Grube D. The Merkel cell: A member of the APUD cell system. Fluorescence and electron microscopic contribution to the neurotransmitter function of the Merkel cell granules. Arch Dermatol Res 1979;265:115-22.
10. Boot PM, Rowden G, Walsh N. The distribution of Merkel cells in human fetal and adult skin. Am J Dermatopathol 1992;14:391-6.
11. Lucarz A, Brand G. Current considerations about Merkel cell. Eur J Cell Biol 2007;86:243-51.
12. Yiengpruksawan A, Coit DG, Thaler HT, Urmacher C, Knapper WK. Merkel cell carcinoma: Prognosis and management. Arch Surg 1991;126:1514-9.
13. Goepfert H, Remmler D, Silva E, Wheeler B. Merkel cell carcinoma (endocrine carcinoma of the skin) of the head and neck. Arch Otolaryngol 1984;110:707-12.
14. Polakovicova S, Seidenberg H, Mikusova R, Polak S, Pospisilova V. Merkel cells-review on developmental, functional and clinical aspects. Bratisl Lek Listy 2011;112:80-7.
15. Winkelmann RK. The Merkel cell system and a comparison between it and the neurosecretory or APUD cell system. J Invest Dermatol 1977;69:41-6.
16. Winkelmann RK, Breathnach AS. The Merkel cell. J Invest Dermatol 1973;60:2-15.
17. Hartschuh W, Weihe E. Fine structural analysis of the synaptic junction of Merkel cell-Axon-complexes. J Invest Dermatol 1980;75:159-5.
18. Watanabe IS. Ultrastructures of mechanoreceptors in the oral mucosa. Anat Sci Int 2004;79:55-61.
19. Toyoshima K, Seta Y, Nakashima T, Shimamura A. Occurrence of melanosome-containing Merkel cell in mammalian oral mucosa. Acta Anat (Basel) 1993;147:145-8.
20. Goessling W, McKee PH, Mayer RJ. Merkel cell carcinoma. J Clin Oncol 2002;20:588-98.
21. Scott MP, Helm OF. Cytokeratin 20: A marker for diagnosing Merkel cell carcinoma. Am J Dermatopathol 1999;21:16-20.
22. Linjawi A, Jamison WB, Meterissian S. Merkel cell carcinoma: Important aspects of diagnosis and management. Am Surg 2001;67:943-7.
23. Hill AD, Brady MS, Coit DG. Intraoperative lymphatic mapping and sentinel lymph node biopsy for Merkel cell carcinoma. Br J Surg 1999;86:518-1.
24. Al-Ghazal SK, Arora DS, Simpson RH, Saxby P. Merkel cell carcinoma of the skin. Br J Plast Surg 1996;49:491-6.
25. Succaria F, Radfar A, Bhawan J. Merkel Cell Carcinoma (Primary Neuroendocrine Carcinoma of Skin) Mimicking Basal Cell Carcinoma With Review of Different Histopathologic Features. Am J Dermatopathol 2013.
26. Feng H, Shuda M, Chang Y, Moore PS. Clonal Integration of a polyomavirus in human merkel cell carcinoma. Science 2008;319:1096-100.
27. Hitchcock CL, Bland KI, Laney RG. Neuroendocrine (Merkel cell) carcinoma of the skin. Its natural history, diagnosis, and treatment. Ann Surg 1988;207:201.
28. Shuda M, Feng H, Kwun HJ, Rosen ST, Gjoerup O, Moore PS, et al. T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus. Proc Natl Acad Sci U S A 2008;105:16272-7.
29. Toker C. Trabecular carcinoma of the skin. Arch Dermatol 1972;105:107-10.
30. Ratner D, Nelson BR, Brown MD, Johnson TM. Merkel cell carcinoma. J Am Acad Dermatol 1993;29:143-56.
31. Gould VE, Moll R, Moll I, Lee I, Franke WW. Neuroendocrine (Merkel) cells of the skin: Hyperplasias, dysplasias, and neoplasms. Lab Invest 1985;52:334-53.
32. Pulitzer MP, Amin BD, Busam KJ. Merkel cell carcinoma: Review. Adv Anat Pathol 2009;16:135-44.
33. Miles BA. Merkel Cell Carcinoma of the Head and Neck: Challenges in Diagnosis and Therapy. J Skin Cancer. 2013;2013: 1. Article ID 427984 Available from: Http://www. hindawi.com/journals/jsc/2013/427984/[Last accessed on 2013 Jun 26].