Promising neuroprotective effects of the angiotensin-(1-7)-angiotensin-converting enzyme 2-Mas axis in stroke

Experimental Physiology

Volumn 99, Issue 2, 2014, Pages 342-343

  Peña Silva, Ricardo A ^a   Heistad, Donald D ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN[1-7]; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR MAS; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

BLOOD BRAIN BARRIER; BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN HEMORRHAGE; CEREBROVASCULAR ACCIDENT; DRUG PENETRATION; EDITORIAL; HUMAN; LIPID PEROXIDATION; MICROTHROMBUS; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; OXIDATIVE STRESS;

ANGIOTENSIN I; ANIMALS; HYPERTENSION; MALE; PEPTIDE FRAGMENTS; STROKE;

EID: 84893380456     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2013.076836     Document Type: Editorial

References (11)

1. Jiang T, Gao L, Guo J, Lu J, Wang Y & Zhang Y (2012). Suppressing inflammation by inhibiting the NF-κB pathway contributes to the neuroprotective effect of angiotensin-(1-7) in rats with permanent cerebral ischaemia. Br J Pharmacol 167, 1520-1532.
2. Jiang T, Gao L, Shi J, Lu J, Wang Y & Zhang Y (2013a). Angiotensin-(1-7) modulates renin-angiotensin system associated with reducing oxidative stress and attenuating neuronal apoptosis in the brain of hypertensive rats. Pharmacol Res 67, 84-93.
3. Jiang T, Gao L, Zhu XC, Yu JT, Shi JQ, Tan MS, Lu J, Tan L & Zhang YD (2013b). Angiotensin-(1-7) inhibits autophagy in the brain of spontaneously hypertensive rats. Pharmacol Res 71, 61-68.
4. Lu J, Jiang T, Wu L, Gao L, Wang Y, Zhou F, Zhang S & Zhang Y (2013). The expression of angiotensin-converting enzyme 2- angiotensin-(1-7)-Mas receptor axis are upregulated after acute cerebral ischemic stroke in rats. Neuropeptides 47, 289-295.
5. Mecca AP, O'Connor TE, Katovich MJ & Sumners C (2009). Candesartan pretreatment is cerebroprotective in a rat model of endothelin-1-induced middle cerebral artery occlusion. Exp Physiol 94, 937-946.
6. Mecca AP, Regenhardt RW, O'Connor TE, Joseph JP, Raizada MK, Katovich MJ & Sumners C (2011). Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke. Exp Physiol 96, 1084-1096.
7. Passos-Silva DG, Verano-Braga T & Santos RA (2013). Angiotensin-(1-7): beyond the cardio-renal actions. Clin Sci (Lond) 124, 443-456.
8. Peña Silva RA, Chu Y, Miller JD, Mitchell IJ, Penninger JM, Faraci FM & Heistad DD (2012). Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging. Stroke 43, 3358-3363.
9. Regenhardt RW, Desland F, Mecca AP, Pioquinto DJ, Afzal A, Mocco J & Sumners C (2013). Anti-inflammatory effects of angiotensin-(1-7) in ischemic stroke. Neuropharmacology 71, 154-163.
10. Regenhardt RW, Mecca AP, Desland F, Ritucci-Chinni PF, Ludin JA, Greenstein D, Banuelos C, Bizon JL, Reinhard MK & Sumners C (2014). Centrally administered angiotensin-(1-7) increases the survival of stroke-prone spontaneously hypertensive rats. Exp Physiol 99, 442-453.
11. Schreiber S, Bueche CZ, Garz C, Kropf S, Angenstein F, Goldschmidt J, Neumann J, Heinze HJ, Goertler M, Reymann KG & Braun H (2012). The pathologic cascade of cerebrovascular lesions in SHRSP: is erythrocyte accumulation an early phase? J Cereb Blood Flow Metab 32, 278-290.