Micron-particle transport, interactions and deposition in triple lung-airway bifurcations using a novel modeling approach

Journal of Aerosol Science

Volumn 71, Issue , 2014, Pages 1-15

  Feng, Y ^a   Kleinstreuer, C ^a,b  

^a North Carolina State University   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Dense discrete phase model (DDPM); Discrete element method (DEM); Lung aerosol dynamics; Model combination criteria; Particle particle interactions; Triple bifurcations

Indexed keywords

AEROSOLS; BIFURCATION (MATHEMATICS); BIOLOGICAL ORGANS; COST EFFECTIVENESS; DEPOSITION; DYNAMICS; FINITE DIFFERENCE METHOD; HEALTH RISKS; NANOPARTICLES; PARTICLE INTERACTIONS; PARTICLE SEPARATORS; RESPIRATORY SYSTEM; RISK ASSESSMENT; RISK PERCEPTION;

AEROSOL DYNAMICS; COMPUTATIONAL FLUID-PARTICLE DYNAMICS; DISCRETE PHASE MODEL; HUMAN RESPIRATORY SYSTEM; MODEL COMBINATION; PARTICLE DEPOSITION MECHANISM; PARTICLE-PARTICLE INTERACTIONS; PARTICLE-WALL INTERACTIONS;

SUSPENSIONS (FLUIDS);

BIFURCATION; COLLISION; COMPUTER SIMULATION; EULER FLOW; FRACTIONATION; MATHEMATICAL ANALYSIS; NUMERICAL MODEL; PARTICULATE MATTER; VELOCITY; VISUALIZATION;

AEROSOL; ARTICLE; CONTROLLED STUDY; COST; DYNAMICS; GAS TRANSPORT; GEOMETRY; HEALTH HAZARD; LUNG; MOLECULAR INTERACTION; PREDICTION; PRIORITY JOURNAL; RESPIRATORY SYSTEM; SIMULATION;

EID: 84893376681     PISSN: 00218502     EISSN: 18791964     Source Type: Journal    
DOI: 10.1016/j.jaerosci.2014.01.003     Document Type: Article

References (36)

1. Aljuri, N., Venegas, J.G., Nair, A., Perkins, R.C. (2012). U.S. Patent No. 8,137,302. Washington, DC: U.S. Patent and Trademark Office.
2. Alobaid F., Ströhle J., Epple B. Extended CFD/DEM model for the simulation of circulating fluidized bed. Advanced Powder Technology 2012, 24(1):403-415.
3. Armstrong B., de Wit C.C. Friction modeling and compensation. The Control Handbook 1996, 77:1369-1382.
4. Chen X., Zhong W., Zhou X., Jin B., Sun B. CFD-DEM simulation of particle transport and deposition in pulmonary airway. Powder Technology 2012, 228:309-318.
5. Comer J.K., Kleinstreuer C., Hyun S., Kim C.S. Aerosol transport and deposition in sequentially bifurcating airways. Journal of Biomechanical Engineering 2000, 122(2):152-158.
6. Crowe C.T., Schwarzkopf J.D., Sommerfeld M., Tsuji Y. Multiphase Flows with Droplets and Particles 2011, CRC Press, Boca Raton, FL, USA. 2nd ed.
7. Cui, X. (2012). CFD study of the flow field and particle dispersion and deposition in the upper human respiratory system (Ph.D. dissertation). Germany: Ruperto-Carola University of Heidelberg.
8. Cundall P.A., Strack O.D.L. A discrete numerical model for granular assemblies. Geotechnique 1979, 29:47-65.
9. Di Renzo A., Cello F., Di Maio F.P. Simulation of the layer inversion phenomenon in binary liquid-fluidized beds by DEM-CFD with a Drag Law for polydisperse systems. Chemical Engineering Science 2011, 66:2945-2958.
10. Ergun S. Fluid flow through packed columns. Chemical Engneering Progress 1952, 48:89-94.
11. Feng, Y. (2013). Computational ellipsoidal particle-fluid analysis and discrete element method with applications to particle transport and deposition in human respiratory models (Ph.D. dissertation). Raleigh, NC, USA: North Carolina State University.
12. Hilton J.E., Cleary P.W. The influence of particle shape on flow modes in pneumatic conveying. Chemical Engineering Science 2011, 66(3):231-240.
13. Johnson R.W. The Handbook of Fluid Dynamics 1998, Springer-Verlag, Heidelberg, Germany. 1st ed.
14. Kafui K.D., Thornton C., Adams M.J. Discrete particle-continuum fluid modelling of gas-solid fluidized beds. Chemical Engineering Science 2002, 57:2395-2410.
15. Kim C.S., Fisher D.M. Deposition characteristics of aerosol particles in sequentially bifurcating airway models. Aerosol Science & Technology 1999, 31(2-3):198-220.
16. Kleinstreuer C., Zhang Z., Donohue J.F. Targeted Drug-Aerosol Delivery in the Human respiratory System. Annual Review of Biomedical Engineering 2008, 10:195-220.
17. Kleinstreuer C., Feng Y. Lung deposition analyses of inhaled toxic aerosols in conventional and less harmful cigarette smoke: a review. International Journal of Environmental Research and Public Health 2013, 10(9):4454-4485.
18. Kolanjiyil A.V., Kleinstreuer C. Nanoparticle mass transfer from lung airways to systemic regions - Part I: whole-lung aerosol dynamics. Journal of Biomechanical Engineering 2013, 135(12). (No. 121003-1-121003-11).
19. Kolanjiyil A.V., Kleinstreuer C. Nanoparticle mass transfer from lung airways to systemic regions-Part II: multi-compartmental modeling. Journal of Biomechanical Engineering 2013, 135(12). (121004-1-121004-12).
20. Li H., Li Y., Gao F., Zhao Z., Xu L. CFD-DEM simulation of material motion in air-and-screen cleaning device. Computers and Electronics in Agriculture 2012, 88:111-119.
21. Loth E. Computational Fluid Dynamics of Bubbles, Drops and Particles 2008, Cambridge University Press, Cambridge, UK.
22. Mader K., Tomas J. Modeling of the contact behavioour between fine adhesive particles with viscous damping. Discrete Element Modelling of Particulate Media 2012, 339:89-112. The Royal Society of Chemistry, Cambridge, UK.
23. Neuwirth J., Antonyuk S., Heinrich S., Jacob M. CFD-DEM study and direct measurement of the granular flow in a rotor granulator. Chemical Engineering Science 2012, 86:151-163.
24. O'Sullivan C., Bray J.D. Selecting a suitable time step for discrete element simulations that use the central difference time integration scheme. Engineering Computations 2004, 21:278-303.
25. Raji, A.O. (1999). Discrete element modelling of the deformation of bulk agricultural particulates (Doctoral dissertation). UK: University of Newcastle upon Tyne.
26. Ren B., Zhong W., Jin B., Yuan Z., Lu Y. Modeling of gas-particle turbulent flow in spout-fluid bed by computational fluid dynamics with Discrete Element Method. Chemical Engineering & Technology 2011, 34(12):2059-2068.
27. Tong Z.B., Yang R.Y., Chu K.W., Yu A.B., Adi S., Chan H.K. Numerical study of the effects of particle size and polydispersity on the agglomerate dispersion in a cyclonic flow. Chemical Engineering Journal 2010, 164(2):432-441.
28. Tong Z.B., Zheng B., Yang R.Y., Yu A.B., Chan H.K. CFD-DEM investigation of the dispersion mechanisms in commercial dry powder inhalers. Powder Technology 2012, 240:19-24.
29. Tsuji Y., Kawaguchi T., Tanaka T. Discrete particle simulation of 2-dimensional fluidized-bed. Powder Technology 1993, 77:79-87.
30. Tsuji Y., Tanaka T., Ishida T. Lagrangian numerical simulation of plug flow of cohesionless particles in a horizontal pipe. Powder Technology 1992, 71(3):239-250.
31. Van der Hoef M.A., van Sint Annaland M., Deen N.G., Kuipers J.A.M. Numerical simulation of dense gas-solid fluidized beds: a multiscale modeling strategy. Annual Review of Fluid Mechanics 2008, 40:47-70.
32. Wang G.Q., Hao W.J., Wang J.X. Discrete Element Method and Its Application using EDEM 2010, Northwestern Polytechnical University Press, Xi[U+05F3]an, China.
33. Weibel E.R. Morphometry of the Human Lung 1963, Academic Press, New York, NY, USA.
34. Wen Y.C., Yu Y.H. Mechanics of fluidization. Chemical Engineering Progress Symposium Series 1966, 62:100-111.
35. Wong W., Fletcher D.F., Traini D., Chan H.K., Young P.M. The use of computational approaches in inhaler development. Advanced drug delivery reviews 2012, 64(4):312-322.
36. Zhang Z., Kleinstreuer C. Effect of particle inlet distribution on deposition in a triple bifurcation lung airway model. Journal of Aerosol Medicine 2001, 14(1):13-29.