The Utility of middle cerebral artery clot density and burden assessment by noncontrast computed tomography in acute ischemic stroke patients treated with thrombolysis

Journal of Stroke and Cerebrovascular Diseases

Volumn 23, Issue 2, 2014, Pages

  Topcuoglu, Mehmet A ^a   Arsava, E Murat ^a   Kursun, Oguzhan ^b   Akpinar, Erhan ^a   Erbil, Bulent ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

^b ANKARA TRAINING AND RESEARCH HOSPITAL   (Turkey)

Author keywords

attenuation; computerized tomography; Hounsfield unit; middle cerebral artery; prognosis; stroke

Indexed keywords

ALTEPLASE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD CLOT; BLOOD CLOT LYSIS; BRAIN ISCHEMIA; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE SEVERITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MIDDLE CEREBRAL ARTERY; MIDDLE CEREBRAL ARTERY OCCLUSION; MULTIVARIATE ANALYSIS; PREDICTIVE VALUE; PRIORITY JOURNAL; PROGNOSIS; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; STROKE PATIENT; THROMBOSIS; THROMBUS; VERTEBRAL ARTERY STENOSIS; VERTEBROBASILAR CIRCULATION STROKE; VERTEBROBASILAR OCCLUSION;

ATTENUATION; COMPUTERIZED TOMOGRAPHY; HOUNSFIELD UNIT; MIDDLE CEREBRAL ARTERY; PROGNOSIS; STROKE;

AGED; AGED, 80 AND OVER; AREA UNDER CURVE; BRAIN ISCHEMIA; CASE-CONTROL STUDIES; CEREBRAL ANGIOGRAPHY; FEMALE; FIBRINOLYTIC AGENTS; HUMANS; MALE; MIDDLE AGED; MIDDLE CEREBRAL ARTERY; PREDICTIVE VALUE OF TESTS; RECOVERY OF FUNCTION; RISK FACTORS; ROC CURVE; SEVERITY OF ILLNESS INDEX; STROKE; THROMBOLYTIC THERAPY; THROMBOSIS; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT OUTCOME;

EID: 84893349716     PISSN: 10523057     EISSN: 15328511     Source Type: Journal    
DOI: 10.1016/j.jstrokecerebrovasdis.2013.08.026     Document Type: Article

References (29)

1. D.S. Liebeskind, N. Sanossian, and W.H. Yong et al. CT and MRI early vessel signs reflect clot composition in acute stroke Stroke 42 2011 1237 1243
2. J. Puig, S. Pedraza, and A. Demchuk et al. Quantification of thrombus Hounsfield units on noncontrast CT predicts stroke subtype and early recanalization after intravenous recombinant tissue plasminogen activator AJNR Am J Neuroradiol 33 2012 90 96
3. E.Y. Kim, J.H. Heo, and S.K. Lee et al. Prediction of thrombolytic efficacy in acute ischemic stroke using thin-section noncontrast CT Neurology 67 2006 1846 1848
4. A.D. Barreto, K.C. Albright, and H. Hallevi et al. Thrombus burden is associated with clinical outcome after intra-arterial therapy for acute ischemic stroke Stroke 39 2008 3231 3235
5. I.Y. Tan, A.M. Demchuk, and J. Hopyan et al. CT angiography clot burden score and collateral score: correlation with clinical and radiologic outcomes in acute middle cerebral artery infarct AJNR Am J Neuroradiol 30 2009 525 531
6. V. Puetz, I. Dzialowski, and M.D. Hill et al. Intracranial thrombus extent predicts clinical outcome, final infarct size and hemorrhagic transformation in ischemic stroke: the clot burden score Int J Stroke 3 2008 230 236
7. P. Moftakhar, J.D. English, and D.L. Cooke et al. Density of thrombus on admission CT predicts revascularization efficacy in large vessel occlusion acute ischemic stroke Stroke 44 2013 243 245
8. T. Brott, H.P. Adams Jr., and C.P. Olinger et al. Measurements of acute cerebral infarction: a clinical examination scale Stroke 20 1989 864 870
9. J.L. Banks, and C.A. Marotta Outcomes validity and reliability of the modified Rankin scale: implications for stroke clinical trials: a literature review and synthesis Stroke 38 2007 1091 1096
10. L.A. Labiche, F. Al-Senani, and A.W. Wojner et al. Is the benefit of early recanalization sustained at 3 months? A prospective cohort study Stroke 34 2003 695 698
11. H. Ay, K.L. Furie, and A. Singhal et al. An evidence-based causative classification system for acute ischemic stroke Ann Neurol 58 2005 688 697
12. D. Leys, J.P. Pruvo, and O. Godefroy et al. Prevalence and significance of hyperdense middle cerebral artery in acute stroke Stroke 23 1992 317 324
13. M. Fiorelli, S. Bastianello, and R. von Kummer et al. Hemorrhagic transformation within 36 hours of a cerebral infarct: relationships with early clinical deterioration and 3-month outcome in the European Cooperative Acute Stroke Study I (ECASS I) cohort Stroke 30 1999 2280 2284
14. G.V. Goldmakher, E.C. Camargo, and K.L. Furie et al. Hyperdense basilar artery sign on unenhanced CT predicts thrombus and outcome in acute posterior circulation stroke Stroke 40 2009 134 139
15. R.A. Rauch, C. Bazan III, and E.M. Larsson et al. Hyperdense middle cerebral arteries identified on CT as a false sign of vascular occlusion AJNR Am J Neuroradiol 14 1993 669 673
16. G. Gacs, A.J. Fox, and H.J. Barnett et al. CT visualization of intracranial arterial thromboembolism Stroke 14 1983 756 762
17. C. Manelfe, V. Larrue, and R. von Kummer et al. Association of hyperdense middle cerebral artery sign with clinical outcome in patients treated with tissue plasminogen activator Stroke 30 1999 769 772
18. T. Kharitonova, N. Ahmed, and M. Thoren et al. Hyperdense middle cerebral artery sign on admission CT scan - prognostic significance for ischaemic stroke patients treated with intravenous thrombolysis in the safe implementation of thrombolysis in Stroke International Stroke Thrombolysis Register Cerebrovasc Dis 27 2009 51 59
19. K. Abul-Kasim, M. Brizzi, and J. Petersson Hyperdense middle cerebral artery sign is an ominous prognostic marker despite optimal workflow Acta Neurol Scand 122 2010 132 139
20. M.J. Aries, M. Uyttenboogaart, and K. Koopman et al. Hyperdense middle cerebral artery sign and outcome after intravenous thrombolysis for acute ischemic stroke J Neurol Sci 285 2009 114 117
21. M. Zou, L. Churilov, and A. He et al. Hyperdense middle cerebral artery sign is associated with increased risk of hemorrhagic transformation after intravenous thrombolysis for patients with acute ischaemic stroke J Clin Neurosci 20 2013 984 987
22. T. Kharitonova, M. Thoren, and N. Ahmed et al. Disappearing hyperdense middle cerebral artery sign in ischaemic stroke patients treated with intravenous thrombolysis: clinical course and prognostic significance J Neurol Neurosurg Psychiatry 80 2009 273 278
23. S. Flacke, H. Urbach, and E. Keller et al. Middle cerebral artery (MCA) susceptibility sign at susceptibility-based perfusion MR imaging: clinical importance and comparison with hyperdense MCA sign at CT Radiology 215 2000 476 482
24. C.H. Riedel, U. Jensen, and A. Rohr et al. Assessment of thrombus in acute middle cerebral artery occlusion using thin-slice nonenhanced computed tomography reconstructions Stroke 41 2010 1659 1664
25. Shobha N, Bal S, Boyko M, et al. Measurement of length of hyperdense MCA sign in acute ischemic stroke predicts disappearance after IV tPA. J Neuroimaging, in press
26. P. Agarwal, S. Kumar, and S. Hariharan et al. Hyperdense middle cerebral artery sign: can it be used to select intra-arterial versus intravenous thrombolysis in acute ischemic stroke? Cerebrovasc Dis 17 2004 182 190
27. D. Georgiadis, F. Wirz, and H.C. von Budingen et al. Intravenous thrombolysis in stroke patients with hyperdense middle cerebral artery sign Eur J Neurol 16 2009 162 167
28. H.P. Mattle, M. Arnold, and D. Georgiadis et al. Comparison of intraarterial and intravenous thrombolysis for ischemic stroke with hyperdense middle cerebral artery sign Stroke 39 2008 379 383
29. D.R. Rutgers, J. van der Grond, and G.H. Jansen et al. Radiologic-pathologic correlation of the hyperdense middle cerebral artery sign. A case report Acta Radiol 42 2001 467 469