Nuclear localization of the transcriptional regulator MIER1α requires interaction with HDAC1/2 in breast cancer cells

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Li, Shengnan ^a   Paterno, Gary D ^a   Gillespie, Laura L ^a  

^a MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR ALPHA; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; SHORT HAIRPIN RNA; MIER1 PROTEIN, HUMAN; NUCLEAR PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; BREAST CANCER; CANCER CELL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOWN REGULATION; ELM2 DOMAIN; GENE; GENE FUNCTION; GENE INTERACTION; GENE SILENCING; HUMAN; HUMAN CELL; MIER1ALPHA GENE; NUCLEAR LOCALIZATION SIGNAL; POINT MUTATION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; WILD TYPE; ACTIVE TRANSPORT; BREAST TUMOR; CELL NUCLEUS; CHEMISTRY; MCF 7 CELL LINE; METABOLISM; PATHOLOGY; PROTEIN TERTIARY STRUCTURE;

ACTIVE TRANSPORT, CELL NUCLEUS; BREAST NEOPLASMS; CELL NUCLEUS; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HUMANS; MCF-7 CELLS; NUCLEAR PROTEINS; PROTEIN STRUCTURE, TERTIARY; TRANSCRIPTION FACTORS;

EID: 84893342506     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0084046     Document Type: Article

References (34)

1. Paterno GD, Li Y, Luchman HA, Ryan PJ, Gillespie LL (1997) cDNA cloning of a novel, developmentally regulated immediate early gene activated by fibroblast growth factor and encoding a nuclear protein. J Biol Chem 272: 25591-25595. (Pubitemid 27438871)
2. Ding Z, Gillespie LL, Paterno GD (2003) Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain. Mol Cell Biol 23: 250-258. (Pubitemid 36008518)
3. Blackmore TM, Mercer CF, Paterno GD, Gillespie LL (2008) The transcriptional cofactor MIER1-beta negatively regulates histone acetyltransferase activity of the CREB-binding protein. BMC Res Notes 1: 68.
4. Ding Z, Gillespie LL, Mercer FC, Paterno GD (2004) The SANT domain of human MI-ER1 interacts with Sp1 to interfere with GC box recognition and repress transcription from its own promoter. J Biol Chem 279: 28009-28016. (Pubitemid 38900071)
5. Paterno GD, Ding Z, Lew YY, Nash GW, Mercer FC, et al. (2002) Genomic organization of the human mi-er1 gene and characterization of alternatively spliced isoforms: regulated use of a facultative intron determines subcellular localization. Gene 295: 79-88. (Pubitemid 35283819)
6. Thorne LB, Grant AL, Paterno GD, Gillespie LL (2005) Cloning and characterization of the mouse ortholog of mi-er1. DNA Seq 16: 237-240. (Pubitemid 41657520)
7. Clements JA, Mercer FC, Paterno GD, Gillespie LL (2012) Differential splicing alters subcellular localization of the alpha but not beta isoform of the MIER1 transcriptional regulator in breast cancer cells. PLoS One 7: e32499.
8. McCarthy PL, Mercer FC, Savicky MW, Carter BA, Paterno GD, et al. (2008) Changes in subcellular localisation of MI-ER1 alpha, a novel oestrogen receptoralpha interacting protein, is associated with breast cancer progression. Br J Cancer 99: 639-646.
9. Post JN, Gillespie LL, Paterno GD (2001) Nuclear localization signals in the Xenopus FGF embryonic early response 1 protein. FEBS Lett 502: 41-45. (Pubitemid 32722057)
10. Liu H, Lee ES, Deb Los Reyes A, Zapf JW, Jordan VC (2001) Silencing and reactivation of the selective estrogen receptor modulator-estrogen receptor alpha complex. Cancer Res 61: 3632-3639. (Pubitemid 32694973)
11. Pearce ST, Liu H, Jordan VC (2003) Modulation of estrogen receptor alpha function and stability by tamoxifen and a critical amino acid (Asp-538) in helix 12. J Biol Chem 278: 7630-7638. (Pubitemid 36800772)
12. Rasband WS (1997-2012) U.S. National Institutes of Health, Bethesda, Maryland, USA http://imagej.nih.gov/ij/.Accessed 2013 Nov 20.
13. Ryan PJ, Paterno GD, Gillespie LL (1998) Identification of phosphorylated proteins associated with the fibroblast growth factor receptor type I during early Xenopus development. Biochem Biophys Res Commun 244: 763-767. (Pubitemid 28418142)
14. Paterno GD, Mercer FC, Chayter JJ, Yang X, Robb JD, et al. (1998) Molecular cloning of human er1 cDNA and its differential expression in breast tumours and tumour-derived cell lines. Gene 222: 77-82. (Pubitemid 28566154)
15. Marfori M, Mynott A, Ellis JJ, Mehdi AM, Saunders NF, et al. (2011) Molecular basis for specificity of nuclear import and prediction of nuclear localization. Biochim Biophys Acta 1813: 1562-1577.
16. Bantscheff M, Hopf C, Savitski MM, Dittmann A, Grandi P, et al. (2011) Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Nat Biotechnol 29: 255-265.
17. Joshi P, Greco TM, Guise AJ, Luo Y, Yu F, et al. (2013) The functional interactome landscape of the human histone deacetylase family. Mol Syst Biol 9: 672.
18. Wagstaff KM, Jans DA (2009) Importins and beyond: non-conventional nuclear transport mechanisms. Traffic 10: 1188-1198.
19. Fagotto F, Gluck U, Gumbiner BM (1998) Nuclear localization signalindependent and importin/karyopherin-independent nuclear import of betacatenin. Curr Biol 8: 181-190. (Pubitemid 28126609)
20. Asally M, Yoneda Y (2005) Beta-catenin can act as a nuclear import receptor for its partner transcription factor, lymphocyte enhancer factor-1 (lef-1). Exp Cell Res 308: 357-363.
21. Thompson ME (2010) BRCA1 16 years later: nuclear import and export processes. FEBS J 277: 3072-3078.
22. Argentaro A, Sim H, Kelly S, Preiss S, Clayton A, et al. (2003) A SOX9 defect of calmodulin-dependent nuclear import in campomelic dysplasia/autosomal sex reversal. J Biol Chem 278: 33839-33847. (Pubitemid 37553218)
23. Yang WM, Yao YL, Sun JM, Davie JR, Seto E (1997) Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family. J Biol Chem 272: 28001-28007. (Pubitemid 27473607)
24. de Ruijter AJ, van Gennip AH, Caron HN, Kemp S, van Kuilenburg AB (2003) Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J 370: 737-749. (Pubitemid 36399066)
25. Yang XJ, Seto E (2003) Collaborative spirit of histone deacetylases in regulating chromatin structure and gene expression. Curr Opin Genet Dev 13: 143-153.
26. Haberland M, Montgomery RL, Olson EN (2009) The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet 10: 32-42.
27. Gregoretti IV, Lee YM, Goodson HV (2004) Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis. J Mol Biol 338: 17-31. (Pubitemid 38429783)
28. Banach-Orlowska M, Pilecka I, Torun A, Pyrzynska B, Miaczynska M (2009) Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex. Biochem J 423: 389-400.
29. He S, Sun JM, Li L, Davie JR (2005) Differential intranuclear organization of transcription factors Sp1 and Sp3. Mol Biol Cell 16: 4073-4083. (Pubitemid 41262879)
30. Wang L, Charroux B, Kerridge S, Tsai CC (2008) Atrophin recruits HDAC1/2 and G9a to modify histone H3K9 and to determine cell fates. EMBO Rep 9: 555-562. (Pubitemid 351772919)
31. Mulligan P, Westbrook TF, Ottinger M, Pavlova N, Chang B, et al. (2008) CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. Mol Cell 32: 718-726.
32. Boonyaratanakornkit V, Edwards DP (2007) Receptor mechanisms mediating non-genomic actions of sex steroids. Semin Reprod Med 25: 139-153. (Pubitemid 46676901)
33. Ordonez-Moran P, Munoz A (2009) Nuclear receptors: genomic and nongenomic effects converge. Cell Cycle 8: 1675-1680.
34. Moriarty K, Kim KH, Bender JR (2006) Minireview: estrogen receptormediated rapid signaling. Endocrinology 147: 5557-5563. (Pubitemid 44833471)