A randomized saline-controlled trial of NASHA hyaluronic acid for knee osteoarthritis

Current Medical Research and Opinion

Volumn 30, Issue 2, 2014, Pages 279-286

  Arden, Nigel K ^a   Åkermark, Christian ^b   Andersson, Mats ^c   Todman, Martin G ^d   Altman, Roy D ^e  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b Sport Med   (Sweden)

^c Q Med AB   (Sweden)

^d Smith and Nephew Research Centre   (United Kingdom)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Knee; NASHA hyaluronic acid gel; Osteoarthritis; Saline control

Indexed keywords

HYALURONIC ACID; SODIUM CHLORIDE; ANALGESIC AGENT; DEXTRAN; NASHA-DX COPOLYMER; PLACEBO;

ADULT; AGED; ARTHRALGIA; ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; FOLLOW UP; HUMAN; INJECTION SITE PAIN; INTENTION TO TREAT ANALYSIS; JOINT EFFUSION; JOINT SWELLING; KNEE; KNEE OSTEOARTHRITIS; KNEE PAIN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MULTICENTER STUDY; PATIENT ASSESSMENT; PHYSICAL PERFORMANCE; RANDOMIZED CONTROLLED TRIAL; RIGIDITY; TREATMENT RESPONSE; VERY ELDERLY; WESTERN ONTARIO AND MCMASTER UNIVERSITIES OSTEOARTHRITIS INDEX; YOUNG ADULT; ANALOGS AND DERIVATIVES; DRUG EFFECTS; INTRAARTICULAR DRUG ADMINISTRATION; METHODOLOGY; OSTEOARTHRITIS, KNEE; PAIN; PAIN MEASUREMENT; PROCEDURES; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

AGED; ANALGESICS; DEXTRANS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYALURONIC ACID; INJECTIONS, INTRA-ARTICULAR; KNEE JOINT; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE; PAIN; PAIN MEASUREMENT; PLACEBOS; RESEARCH DESIGN; SEVERITY OF ILLNESS INDEX; SODIUM CHLORIDE; TREATMENT OUTCOME;

EID: 84893317374     PISSN: 03007995     EISSN: 14734877     Source Type: Journal    
DOI: 10.1185/03007995.2013.855631     Document Type: Article

References (33)

1. Hochberg MC, Altman RD, April KT, et al. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res 2012;64:465-74
2. Zhang W, Moskowitz RW, Nuki G, et al. OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidencebased, expert consensus guidelines. Osteoarthritis Cartilage 2008;16: 137-62
3. Zhang W, Nuki G, Moskowitz RW, et al. OARSI recommendations for the management of hip and knee osteoarthritis: Part III: Changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis Cartilage 2010;18:476-99
4. Schilling A, Corey R, Leonard M, et al. Acetaminophen: Old drug, new warnings. Cleve Clin J Med 2010;77:19-27
5. Jones R, Rubin G, Berenbaum F, et al. Gastrointestinal and cardiovascular risks of nonsteroidal anti-inflammatory drugs. Am J Med 2008;121: 464-74
6. Naesdal J, Brown K. NSAID-Associated adverse effects and acid control aids to prevent them: A review of current treatment options. Drug Saf 2006;29:119-32
7. Trelle S, Reichenbach S, Wandel S, et al. Cardiovascular safety of non-steroidal anti-inflammatory drugs: Network meta-Analysis. BMJ 2011;342:c7086
8. Agerup B, Berg P, Akermark C. Non-Animal stabilized hyaluronic acid: A new formulation for the treatment of osteoarthritis. BioDrugs 2005;19:23-30
9. Lindqvist U, Tolmachev V, Kairemo K, et al. Elimination of stabilised hyaluronan from the knee joint in healthy men. Clin Pharmacokinet 2002; 41:603-13
10. Edsman K, Hjelm R, Larkner H, et al. Intra-Articular duration of DurolaneTM after single injection into the rabbit knee. Cartilage 2011;2:384-8
11. Akermark C, Adalberth T, Ericsater J, et al. Patient-perceived efficacy of nonanimal stabilized hyaluronic acid in the treatment of osteoarthritis of the knee. Osteoarthritis Cartilage 2004;12:S147
12. Akermark C, Berg P, Bjorkman A, et al. Non-Animal stabilised hyaluronic acid in the treatment of osteoarthritis of the knee-A tolerability study. Clin Drug Invest 2002;22:157-66
13. Altman RD, Akermark C, Beaulieu AD, et al. Efficacy and safety of a single intra-Articular injection of non-Animal stabilized hyaluronic acid (NASHA) in patients with osteoarthritis of the knee. Osteoarthritis Cartilage 2004;12: 642-9
14. Krocker D, Matziolis G, Tuischer J, et al. Reduction of arthrosis associated knee pain through a single intra-Articular injection of synthetic hyaluronic acid. Z Rheumatol 2006;65:327-31
15. Berg P, Olsson U. Intra-Articular injection of non-Animal stabilised hyaluronic acid (NASHA) for osteoarthritis of the hip: A pilot study. Clin Exp Rheumatol 2004;22:300-6
16. Conrozier T, Couris CM, Mathieu P, et al. Safety, efficacy and predictive factors of efficacy of a single intra-Articular injection of non-Animal-stabilized-hyaluronic-Acid in the hip joint: Results of a standardized follow-up of patients treated for hip osteoarthritis in daily practice. Arch Orthop Trauma Surg 2009;129:843-8
17. OMalley KJ, Suarez-Almazor M, Aniol J, et al. Joint-specific multidimensional assessment of pain (J-MAP): Factor structure, reliability, validity, and responsiveness in patients with knee osteoarthritis. J Rheumatol 2003;30:534-43
18. Schulz KF, Altman DG, Moher D. CONSORT 2010 statement: Updated guidelines for reporting parallel group randomised trials. PLoS Med 2010;7:e1000251
19. Dougados M, Leclaire P, van der Heijde D, et al. Response criteria for clinical trials on osteoarthritis of the knee and hip: A report of the Osteoarthritis Research Society International Standing Committee for Clinical Trials response criteria initiative. Osteoarthritis Cartilage 2000;8:395-403
20. Conrozier T, Mathieu P, Schott AM, et al. Factors predicting long-Term efficacy of Hylan GF-20 viscosupplementation in knee osteoarthritis. Joint Bone Spine 2003;70:128-33
21. Namiki O, Toyoshima H, Morisaki N. Therapeutic effect of intra-Articular injection of high molecular weight hyaluronic acid on osteoarthritis of the knee. Int J Clin Pharmacol Ther Toxicol 1982;20:501-7
22. Berenbaum F, Grifka J, Cazzaniga S, et al. A randomised, double-blind, controlled trial comparing two intra-Articular hyaluronic acid preparations differing by their molecular weight in symptomatic knee osteoarthritis. Ann Rheum Dis 2012;71:1454-60
23. Chevalier X, Jerosch J, Goupille P, et al. Single, intra-Articular treatment with 6ml hylan G-F 20 in patients with symptomatic primary osteoarthritis of the knee: A randomised, multicentre, double-blind, placebo controlled trial. Ann Rheum Dis 2010;69:113-19
24. Strand V, Baraf HS, Lavin PT, et al. A multicenter, randomized controlled trial comparing a single intra-Articular injection of Gel-200, a new crosslinked formulation of hyaluronic acid, to phosphate buffered saline for treatment of osteoarthritis of the knee. Osteoarthritis Cartilage 2012;20: 350-6
25. Roemer FW, Kassim Javaid M, Guermazi A, et al. Anatomical distribution of synovitis in knee osteoarthritis and its association with joint effusion assessed on non-enhanced and contrast-enhanced MRI. Osteoarthritis Cartilage 2010;18:1269-74
26. Baker K, Grainger A, Niu J, et al. Relation of synovitis to knee pain using contrast-enhanced MRIs. Ann Rheum Dis 2010;69:1779-83
27. Hill CL, Hunter DJ, Niu J, et al. Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis. Ann Rheum Dis 2007;66:1599-603
28. Ishijima M, Watari T, Naito K, et al. Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis. Arthritis Res Ther 2011;13:R22
29. Torres L, Dunlop DD, Peterfy C, et al. The relationship between specific tissue lesions and pain severity in persons with knee osteoarthritis. Osteoarthritis Cartilage 2006;14:1033-40
30. Loeuille D, Sauliere N, Champigneulle J, et al. Comparing non-enhanced and enhanced sequences in the assessment of effusion and synovitis in knee OA: Associations with clinical, macroscopic and microscopic features. Osteoarthritis Cartilage 2011;19:1433-9
31. Moreland LW. Intra-Articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: Mechanisms of action. Arthritis Res Ther 2003;5:54-67
32. Strauss EJ, Hart JA, Miller MD, et al. Hyaluronic acid viscosupplementation and osteoarthritis: Current uses and future directions. Am J Sports Med 2009;37:1636-44
33. Bannuru RR, Natov NS, Dasi UR, et al. Therapeutic trajectory following intraarticular hyaluronic acid injection in knee osteoarthritis-meta-Analysis. Osteoarthritis Cartilage 2011;19:611-19