Neuroprotective effect of a triterpenoid saponin isolated from Momordica cymbalaria Fenzl in diabetic peripheral neuropathy

Indian Journal of Pharmacology

Volumn 46, Issue 1, 2014, Pages 76-81

  Koneri, Raju B ^a   Samaddar, Suman ^a   Simi, Sm ^a   Rao, Srinivas T ^a  

^a KARNATAKA COLLEGE OF PHARMACY   (India)

Author keywords

Antioxidant; Diabetic peripheral neuropathy; Neuroprotection; Saponin of Momordica cymbalaria

Indexed keywords

CATALASE; GLYCOSYLATED HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN; INSULIN; LOW DENSITY LIPOPROTEIN; SAPONIN; STREPTOZOCIN; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; TRITERPENOID;

ACUTE TOXICITY; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETES CONTROL; DIABETIC NEUROPATHY; EXPERIMENTAL DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOT PLATE TEST; LATENT PERIOD; LIPID PEROXIDATION; MALE; MOMORDICA CYMBALARIA; MYELINATION; NERVE FIBER; NEUROPATHY; NEUROPROTECTION; NOCICEPTION; NONHUMAN; OXIDATIVE STRESS; RAT; SCIATIC NERVE; SPINAL GANGLION; TAIL FLICK TEST; WISTAR RAT;

ANTIOXIDANT; DIABETIC PERIPHERAL NEUROPATHY; NEUROPROTECTION; SAPONIN OF MOMORDICA CYMBALARIA;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; GANGLIA, SPINAL; MALE; MOMORDICA; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PERIPHERAL NERVOUS SYSTEM DISEASES; RATS; RATS, WISTAR; SCIATIC NERVE; STREPTOZOCIN; TOXICITY TESTS, ACUTE; TRITERPENES;

EID: 84893266701     PISSN: 02537613     EISSN: 19983751     Source Type: Journal    
DOI: 10.4103/0253-7613.125179     Document Type: Article

References (31)

1. Dejgaard A. Pathophysiology and treatment of diabetic neuropathy. Diabetes Med 1998;15: 97-112.
2. Pirart J. Diabetes Mellitus and Its Degenerative Complications: A Prospective Study of 4, 400 Patients Observed Between 1947 and 1973. Diabetes Care 1978;1: 168-88.
3. Grover JK, Yadav S, Vats V. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol 2002;81: 81-100.
4. Kameswararao B, Kesavulu MM, Apparao C. Evaluation of antidiabetic effect of Momordica cymbalaria fruit in alloxan-diabetic rats. Fitoterpia 2003;74: 7-13.
5. Rao BK, Kesavulu MM, Appa Rao C. Antihyperglycemic activity of Momordica Cymbalaria in alloxan diabetic rats. J Ethnopharmacol 2001;78: 67-71.
6. Rao BK, Kesavulu MM, Giri R, Appa Rao C. Antidiabetic and hypolipidemic effect of Momordica Cymbalaria Hook fruit powder in alloxan-diabetic rats. J Ethnopharmacol 1999;67: 103-9.
7. Raju K, Balaraman R. Antidiabetic Mechanisms of Saponins of Momordica Cymbalaria. Phcog Mag 2008;4: 197-206.
8. Kade I, Barbosa N. Aqueous extracts of Sphagneticola trilobata attenuates streptozotocin-induced hyperglycemia in rat models by modulating oxidative stress parameters. Biol Med 2010;2: 1-13.
9. Anoop Austin, P Thirugnanasambantham, E Mayisvren, M Balasubramanian, N Narayanan, S Viswanathan. Effect of a polyherbal formulation (Diaran plus) on streptozotocin induced experimental diabetes. Int J Trop Med 2006;1: 88-92.
10. Baluchnejadmojarad T, Roghani M. Chronic oral Silybum marianum aqueous extract attenuates streptozotocin-diabetic neuropathy. Iranian J Diabetes Lipid Dis 2009;8: 65-76.
11. Pooja, Sharma V, Yadav D. Evaluation of protective effects of Euphorbia thymifolia Linn against streptozotocin induced diabetic neuropathy in rats. Res J Pharm Biol Chem Sci 2011;3: 623-34.
12. Jawaid T, Shakya AK, Mehnaz K, Hussain S. Amitriptyline and sertraline in diabetic neuropathy: A comparative view. Int J Health Res 2008;1: 73-8.
13. Bhanot A, Shri R. A comparative profile of methanol extracts of Allium cepa and Allium sativum in diabetic neuropathy in mice. Pharmacognosy Res 2010;2: 374-84.
14. Mizisin A. Schwann cells in diabetic neuropathy. J Mol Cell Biol 2004;31: 1105-16.
15. Kamiya H, Zhang W, Sima AA. Degeneration of the Golgi and neuronal loss in dorsal root ganglia in diabetic BioBreeding/Worcester rats. Diabetologia 2006;49: 2763-74.
16. Okado-Matsumoto A, Fridovich I. Subcellular Distribution of Superoxide Dismutases (SOD) in Rat Liver: Cu, Zn-SOD in mitochondria. J Biol Chem 2001;276: 38388-93.
17. Goth L. A simple method for determination of serum catalase activity and revision of reference range. Clin Chim Acta 1991;196: 143-51.
18. Liu F, Ng TB. Antioxidative and free radical scavenging activities of selected medicinal herbs. Life Sci 2000;66: 725-35.
19. Jesada P, Sutawadee C, Motonobu G, Weena J, Mitsuru S, Artiwan S. New approach for extraction of charantin from Momordica charantia with pressurized liquid extraction. Sep Purif Technol 2007;52(3): 416-22.
20. Brownlee M, Vlassara H, Cerami A. Nonenzymatic glycosylation and the pathogenesis of diabetic complications. Ann Intern Med 1984;101: 527-37.
21. Raz I, Hasdai D, Seltzer Z, Melmed RN. Effect of hyperglycemia on pain perception and on efficacy of morphine analgesia in rats. Diabeties 1988;37: 1253-9.
22. Simon GS, Dewey WL. Effect of streptozotocin-induced diabetes on the antinociceptive potency of morphine. J Pharmacol Exp Ther 1981;218: 318-23.
23. Tulaporn W, Sithiporn A. Sex-related differences in cisplatin-induced neuropathy in rats. J Med Assoc Thai 2009;92: 1485-91.
24. Zochodne DW, Verge VM, Cheng C, Sun H, Johnston J. Does diabetes target ganglion neurons? Progressive sensory neuron involvement in long-term experimental diabetes. Brain 2001;124: 2319-34.
25. Kishi M, Tanabe J, Schmelzer JD, Low PA. Morphometry of dorsal root ganglion in chronic experimental diabetic neuropathy. Diabetes 2002;51: 819-24.
26. Chu PC, Lin MT, Shian LR, Leu SY. Alterations in physiologic functions and in brain monoamine content in streptozocin-diabetic rats. Diabetes 1986;35: 481-5.
27. Capellini VK, Baldo CF, Celotto AC, Batalhão ME, Cárnio EC, Rodrigues AJ, et al. Oxidative stress is not associated with vascular dysfunction in a model of alloxan-induced diabetic rats. Arq Bras Endocrinol Metab 2010;54: 530-9.
28. Oztork Y, Altan VM, Ari N. Diabetic complications in experimental models. Tr J Med Sci 1998;22: 331-41.
29. Hussain MS, Ahamed KF, Ravichandiran V, Ansari MZ. Evaluation of In Vitro free radical scavenging potential of different fractions of Hygrophila auriculata (K. Schum) Heine. Asian J Trad Med 2009;4: 179-87.
30. Lenzen S. The mechanism of alloxan and Streptozotocin induced diabetes. Diabetologia 2008;51: 216-26.
31. Shanmugasundaram P, Venkataraman S. Anti-nociceptive activity of Hygrophila auriculata (schum) heine. Afr J Tradit Complement Altern Med 2005;2: 62-9.